Challenges in the design of multitarget drugs against multifactorial pathologies: a new life for medicinal chemistry?

Designed Multiple Ligands: Basic Research vs Clinical Outcomes

(2012) L. Costantino et al.   CURRENT MEDICINAL CHEMISTRY

Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors

(2012) Xingyu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modern Phenotypic Drug Discovery Is a Viable, Neoclassic Pharma Strategy

(2012) Jonathan A. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors

(2012) Alicia S Chung et al.   JOURNAL OF PATHOLOGY

Cancer: Limitations of therapies exposed

(2012) Oriol Casanovas   NATURE

News in brief

(2012)   NATURE REVIEWS DRUG DISCOVERY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

The role of fragment-based and computational methods in polypharmacology

(2011) Giovanni Bottegoni et al.   DRUG DISCOVERY TODAY

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Biochemical network-based drug-target prediction

(2010) Edda Klipp et al.   CURRENT OPINION IN BIOTECHNOLOGY

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Structure of Protein Interaction Networks and Their Implications on Drug Design

(2009) Takeshi Hase et al.   PLoS Computational Biology