Recent advances in developing synthetic carbohydrate-based vaccines for cancer immunotherapies

Development, Characterization, and Immunotherapeutic Use of Peptide Mimics of the Thomsen-Friedenreich Carbohydrate Antigen

(2015) Jamie Heimburg-Molinaro et al.   NEOPLASIA

Phase III Multicenter Clinical Trial of the Sialyl-TN (STn)-Keyhole Limpet Hemocyanin (KLH) Vaccine for Metastatic Breast Cancer

(2011) D. Miles et al.   ONCOLOGIST

Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen

(2010) Fan Yang et al.   ACS Chemical Biology

l-Rhamnose Antigen: A Promising Alternative to α-Gal for Cancer Immunotherapies

(2010) Wenlan Chen et al.   ACS Chemical Biology

Synthesis of glycosylated β3-homo-threonine conjugates for mucin-like glycopeptide antigen analogues

(2010) Florian Karch et al.   Beilstein Journal of Organic Chemistry

Synthesis of a BSA-Lex glycoconjugate and recognition of Lex analogues by the anti-Lex monoclonal antibody SH1: The identification of a non-cross reactive analogue

(2010) Jo-Wen Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effects of Hapten Density on the Induced Antibody Repertoire

(2010) Qian Li et al.   CHEMBIOCHEM

Fluorinated Glycosyl Amino Acids for Mucin-Like Glycopeptide Antigen Analogues

(2010) Sarah Wagner et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of a Single-Moleculel-Rhamnose-Containing Three-Component Vaccine and Evaluation of Antigenicity in the Presence of Anti-l-Rhamnose Antibodies

(2010) Sourav Sarkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Linear and Branched Glyco-Lipopeptide Vaccines Follow Distinct Cross-Presentation Pathways and Generate Different Magnitudes of Antitumor Immunity

(2010) Olivier Renaudet et al.   PLoS One

Synthesis of 2-aminoethyl 3′-(N-glycolylneuraminyl)-β-actoside and neoglycoconjugates based thereon — a prototype of a cancer vaccine and artificial antigens for the control of immune response

(2010) E. A. Khatuntseva et al.   RUSSIAN CHEMICAL BULLETIN

Synthesis of N-modified sTn analogs and evaluation of their immunogenicities by microarray-based immunoassay

(2010) Sk Sahabuddin et al.   TETRAHEDRON

A Synthetic Vaccine Consisting of a Tumor-Associated Sialyl-TN-MUC1 Tandem-Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly Selective Immune Response

(2009) Anton Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of sialyl Lewisa (sLea, CA19-9) and construction of an immunogenic sLea vaccine

(2009) Govind Ragupathi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

(2009) Therese Buskas et al.   CHEMICAL COMMUNICATIONS

Synthesis of a Monophosphoryl Derivative ofEscherichia coliLipid A and Its Efficient Coupling to a Tumor-Associated Carbohydrate Antigen

(2009) Shouchu Tang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Induction of a Melanoma-Specific Antibody Response by a Monovalent, but not a Divalent, Synthetic GM2 Neoglycopeptide

(2009) S. Bay et al.   ChemMedChem

Recent development in carbohydrate-based cancer vaccines

(2009) Zhongwu Guo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience

(2009) Jianglong Zhu et al.   Expert Review of Vaccines

The Lewis-Y Carbohydrate Antigen is Expressed by Many Human Tumors and Can Serve as a Target for Genetically Redirected T cells Despite the Presence of Soluble Antigen in Serum

(2009) Jennifer A. Westwood et al.   JOURNAL OF IMMUNOTHERAPY

On the Emerging Role of Chemistry in the Fashioning of Biologics: Synthesis of a Bidomainal Fucosyl GM1-Based Vaccine for the Treatment of Small Cell Lung Cancer

(2009) Pavel Nagorny et al.   JOURNAL OF ORGANIC CHEMISTRY

Profiling Human Serum Antibodies with a Carbohydrate Antigen Microarray

(2009) Oyindasola Oyelaran et al.   JOURNAL OF PROTEOME RESEARCH

From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Model for the Presentation of Tumor-Associated Antigens and the Quest for an Anticancer Vaccine: A Solution to the Synthesis Challenge via Ring-Closing Metathesis

(2009) Insik Jeon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biologics through Chemistry: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer by Orchestration of Oligosaccharide and Polypeptide Domains

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Merging Nucleophilic and Hydrogen Bonding Catalysis: An Anion Binding Approach to the Kinetic Resolution of Amines

(2009) Chandra Kanta De et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anti-carbohydrate antibodies of normal sera: Findings, surprises and challenges

(2009) Margaret E. Huflejt et al.   MOLECULAR IMMUNOLOGY

The cancer vaccine roller coaster

(2009) Bruce Goldman et al.   NATURE BIOTECHNOLOGY

Immune surveillance and immunotherapy: Lessons from carbohydrate mimotopes

(2009) Anastas Pashov et al.   VACCINE

Synthetic and Immunological Studies of5′-N-Phenylacetyl sTn to Develop Carbohydrate-Based Cancer Vaccines and to Explore the Impacts of Linkage between Carbohydrate Antigens and Carrier Proteins

(2008) Qianli Wang et al.   BIOCONJUGATE CHEMISTRY

Carbohydrate-Mediated Targeting of Antigen to Dendritic Cells Leads to Enhanced Presentation of Antigen to T Cells

(2008) Eddie W. Adams et al.   CHEMBIOCHEM

A Novel Linker Methodology for the Synthesis of Tailored Conjugate Vaccines Composed of Complex Carbohydrate Antigens and Specific TH‐Cell Peptide Epitopes

(2008) Sebastian Dziadek et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Immunochemical characterization ofS-linked Glycoconjugate Vaccines againstCandida albicans

(2008) Xiangyang Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Towards a Self-Adjuvanting Multivalent B and T cell Epitope Containing Synthetic Glycolipopeptide Cancer Vaccine

(2008) Olivier Renaudet et al.   ChemMedChem

Aberrant Expression of Carbohydrate Antigens in Cancer: The Role of Genetic and Epigenetic Regulation

(2008) Young S. Kim et al.   GASTROENTEROLOGY

Glycoproteomics for Prostate Cancer Detection: Changes in Serum PSA Glycosylation Patterns

(2008) Danni L. Meany et al.   JOURNAL OF PROTEOME RESEARCH

An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions

(2008) J. G. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants—Hakomori's concepts revisited

(2007) Reiji Kannagi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Galα1,3Galβ1,4GlcNAc-R (α-Gal) epitope: A carbohydrate of unique evolution and clinical relevance

(2007) Bruce A. Macher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Preparation of glycoconjugates by dialkyl squarate chemistry revisited

(2007) Shu-jie Hou et al.   CARBOHYDRATE RESEARCH

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS