Therapeutic potential of CCR1 antagonists for multiple myeloma

Chemokine Receptor CCR1 Regulates Inflammatory Cell Infiltration after Renal Ischemia-Reperfusion Injury

(2014) K. Furuichi et al.   JOURNAL OF IMMUNOLOGY

Pharmacokinetic and Pharmacodynamic Evaluation of the Novel CCR1 Antagonist CCX354 in Healthy Human Subjects: Implications for Selection of Clinical Dose

(2011) D J Dairaghi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

CCR1 as a target for multiple myeloma

(2011) Sonia Vallet et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

(2011) S Vallet et al.   LEUKEMIA

Novel pyrrolidine heterocycles as CCR1 antagonists

(2010) J. Robert Merritt et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluation of the effect of the specific CCR1 antagonist CP-481715 on the clinical and cellular responses observed following epicutaneous nickel challenge in human subjects

(2010) Jeanett Borregaard et al.   CONTACT DERMATITIS

CCR1 Antagonists: What Have We Learned From Clinical Trials

(2010) Ronald P. Gladue et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Deficiency of Chemokine Receptor CCR1 Causes Osteopenia Due to Impaired Functions of Osteoclasts and Osteoblasts

(2010) Akiyoshi Hoshino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the bone microenvironment in multiple myeloma

(2010) G. David Roodman   JOURNAL OF BONE AND MINERAL METABOLISM

Macrophage inflammatory protein-1α induces osteoclast formation by activation of the MEK/ERK/c-Fos pathway and inhibition of the p38MAPK/IRF-3/IFN-β pathway

(2010) Masanobu Tsubaki et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

No significant effect of orally administered chemokine receptor 1 antagonist on intercellular adhesion molecule-3 expression in relapsing—remitting multiple sclerosis patients

(2010) R. Reuβ et al.   Multiple Sclerosis Journal

Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients

(2010) Huib A. Kerstjens et al.   RESPIRATORY MEDICINE

VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist

(2009) L. Rihakova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

(2009) Clarissa E. Vergunst et al.   ARTHRITIS AND RHEUMATISM

AZD-4818, a chemokine CCR1 antagonist: WO2008103126 and WO2009011653

(2009) Peter Norman   EXPERT OPINION ON THERAPEUTIC PATENTS

Chemokine receptor antagonists: Part 1

(2009) James E Pease et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

CCR1-mediated activation of nuclear factor-κB in THP-1 monocytic cells involves pertussis toxin-insensitive Gα14 and Gα16 signaling cascades

(2009) Maggie M. K. Lee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Novel Pyrrolidine Ureas as C−C Chemokine Receptor 1 (CCR1) Antagonists

(2009) J. Robert Merritt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multiple myeloma

(2009) Marc S Raab et al.   LANCET

Myeloma Bone Disease: Recent Advances in Biology, Diagnosis, and Treatment

(2009) O. Sezer   ONCOLOGIST

Osteoclast lineage and function

(2008) H. Kalervo Väänänen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Macrophage Inflammatory Protein-1 : A Novel Osteoclast Stimulating Factor Secreted by Renal Cell Carcinoma Bone Metastasis

(2008) S. L. Kominsky et al.   CANCER RESEARCH

Differential involvement of Gα16 in CC chemokine-induced stimulation of phospholipase Cβ, ERK, and chemotaxis

(2008) Yaji Tian et al.   CELLULAR SIGNALLING

The Use of Immortalized Cell Lines in GPCR Screening: The Good, Bad and Ugly.

(2008) Richard Eglen et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Interfering with chemokines and chemokine receptors as potential new therapeutic strategies

(2008) Mario Milco D'Elios et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction

(2008) E. A. Liehn et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of novel series of human CCR1 antagonists

(2007) Yun Feng Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Heterotrimeric G-proteins: a short history

(2006) Graeme Milligan et al.   BRITISH JOURNAL OF PHARMACOLOGY