Emerging role of surface plasmon resonance in fragment-based drug discovery

Weak affinity chromatography as a new approach for fragment screening in drug discovery

(2011) Minh-Dao Duong-Thi et al.   ANALYTICAL BIOCHEMISTRY

Ligand specificity, privileged substructures and protein druggability from fragment-based screening

(2011) Sarah Barelier et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fragment screening to predict druggability (ligandability) and lead discovery success

(2011) Fredrik N.B. Edfeldt et al.   DRUG DISCOVERY TODAY

Fragment-based lead discovery: challenges and opportunities

(2011) Chaohong Sun et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A comparative study of fragment screening methods on the p38α kinase: new methods, new insights

(2011) Scott J. Pollack et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Identification of a Novel Scaffold for Allosteric Inhibition of Wild Type and Drug Resistant HIV-1 Reverse Transcriptase by Fragment Library Screening

(2011) Matthis Geitmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Progress in Structure Based Drug Design for G Protein-Coupled Receptors

(2011) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY

Screening for GPCR Ligands Using Surface Plasmon Resonance

(2011) Iva Navratilova et al.   ACS Medicinal Chemistry Letters

Biosensor-based fragment screening using FastStep injections

(2010) Rebecca L. Rich et al.   ANALYTICAL BIOCHEMISTRY

Kinetic analysis and fragment screening with Fujifilm AP-3000

(2010) Rebecca L. Rich et al.   ANALYTICAL BIOCHEMISTRY

Structural biology in fragment-based drug design

(2010) Christopher W Murray et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Identification and Characterization of Acidic Mammalian Chitinase Inhibitors

(2010) Derek C. Cole et al.   JOURNAL OF MEDICINAL CHEMISTRY

The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery

(2010) Nathan Robertson et al.   NEUROPHARMACOLOGY

Fragment Screening by Surface Plasmon Resonance

(2010) Iva Navratilova et al.   ACS Medicinal Chemistry Letters

Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays

(2009) Robert Godemann et al.   BIOCHEMISTRY

The impact of GPCR structures on pharmacology and structure-based drug design

(2009) Miles Congreve et al.   BRITISH JOURNAL OF PHARMACOLOGY

Recent progress in fragment-based lead discovery

(2009) Michèle N Schulz et al.   CURRENT OPINION IN PHARMACOLOGY

Fragment Library Screening and Lead Characterization Using SPR Biosensors

(2009) U. Danielson   CURRENT TOPICS IN MEDICINAL CHEMISTRY

From fragment to clinical candidate—a historical perspective

(2009) Gianni Chessari et al.   DRUG DISCOVERY TODAY

Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process

(2009) U Helena Danielson   Future Medicinal Chemistry

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Adding calorimetric data to decision making in lead discovery: a hot tip

(2009) John E. Ladbury et al.   NATURE REVIEWS DRUG DISCOVERY

Direct optical detection in fragment-based screening

(2008) Florian Pröll et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Thermodynamic characterization of pyrazole and azaindole derivatives binding to p38 mitogen-activated protein kinase using Biacore T100 technology and van’t Hoff analysis

(2008) Giuseppe A. Papalia et al.   ANALYTICAL BIOCHEMISTRY

Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors

(2008) Stephen S. Antonysamy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tyramine fragment binding to BACE-1

(2008) Andreas Kuglstatter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Do enthalpy and entropy distinguish first in class from best in class?

(2008) E FREIRE   DRUG DISCOVERY TODAY

Two ‘Golden Ratio’ indices in fragment-based drug discovery

(2008) Masaya Orita et al.   DRUG DISCOVERY TODAY

Recent Developments in Fragment-Based Drug Discovery

(2008) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY

“Virtual Fragment Linking”: An Approach To Identify Potent Binders from Low Affinity Fragment Hits

(2008) Thomas J. Crisman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

(2008) Helena Nordström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor

(2008) F. Magnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA