Journal
FUTURE MEDICINAL CHEMISTRY
Volume 3, Issue 10, Pages 1279-1288Publisher
FUTURE SCI LTD
DOI: 10.4155/FMC.11.85
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Funding
- National Institute of Allergy and Infectious Diseases
- US Department of Health and Human Services
- National Institutes of Health
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The Sandler Center's approach to target-based drug discovery for neglected tropical diseases is to focus on parasite targets that are homologous to human targets being actively investigated in the pharmaceutical industry. In this way we attempt to use both the know-how and actual chemical matter from other drug-development efforts to jump start the discovery process for neglected tropical diseases. Our approach is akin to drug repurposing, except that we seek to repurpose leads rather than drugs. Medicinal chemistry can then be applied to optimize the leads specifically for the desired antiparasitic indication.
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