Targeting inhibitor of apoptosis proteins for therapeutic intervention

(Un)expected roles of c-IAPs in apoptotic and NFκB signaling pathways

(2011) Eugene Varfolomeev et al.   CELL CYCLE

Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists

(2009) Chudi Ndubaku et al.   ACS Chemical Biology

Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP)

(2009) Julie M. Rumble et al.   CELLULAR IMMUNOLOGY

Development of novel drugs targeting inhibitors of apoptosis

(2009) John A Flygare et al.   Future Oncology

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

(2009) Mathieu J.M. Bertrand et al.   IMMUNITY

Orally Bioavailable Antagonists of Inhibitor of Apoptosis Proteins Based on an Azabicyclooctane Scaffold∞

(2009) Frederick Cohen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP Protein Family

(2009) Federica Cossu et al.   JOURNAL OF MOLECULAR BIOLOGY

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics

(2008) Haiying Sun et al.   ACCOUNTS OF CHEMICAL RESEARCH

Inhibitors of apoptosis catch ubiquitin: Figure 1

(2008) Krishnaraj Rajalingam et al.   BIOCHEMICAL JOURNAL

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP21

(2008) John W. Blankenship et al.   BIOCHEMICAL JOURNAL

Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein†‡

(2008) Zaneta Nikolovska-Coleska et al.   BIOCHEMISTRY

Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas

(2008) J. N. Dynek et al.   CANCER RESEARCH

Targeting IAP (Inhibitor of Apoptosis) Proteins for Therapeutic Intervention in Tumors

(2008) Domagoj Vucic   CURRENT CANCER DRUG TARGETS

Ubiquitin-mediated regulation of TNFR1 signaling

(2008) Ingrid E. Wertz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Targeting survivin in cancer therapy

(2008) Marzia Pennati et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Regulation of apoptosis by XIAP ubiquitin-ligase activity

(2008) A. J. Schile et al.   GENES & DEVELOPMENT

Survivin Antisense Oligonucleotides Effectively Radiosensitize Colorectal Cancer Cells in Both Tissue Culture and Murine Xenograft Models

(2008) Franz Rödel et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

(2008) Zuojun Yue et al.   JOURNAL OF CELL BIOLOGY

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

Phase I and Pharmacokinetic Study of YM155, a Small-Molecule Inhibitor of Survivin

(2008) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting

(2008) Andrea Molckovsky et al.   Journal of Hematology & Oncology

Targeted manipulation of apoptosis in cancer treatment

(2008) Justin A Call et al.   LANCET ONCOLOGY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility

(2008) Taner Dogan et al.   NATURE CELL BIOLOGY

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

(2008) Mads Gyrd-Hansen et al.   NATURE CELL BIOLOGY

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Cytoplasmic Translocation of a Cytokine Receptor-Assembled Signaling Complex

(2008) A. Matsuzawa et al.   SCIENCE

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains

(2007) Zaneta Nikolovska-Coleska et al.   ANALYTICAL BIOCHEMISTRY