Approaches to target the genome and its epigenome in cancer

Small Interfering RNAs Induce Macrophage Migration Inhibitory Factor Production and Proliferation in Breast Cancer Cells via a Double-Stranded RNA-Dependent Protein Kinase-Dependent Mechanism

(2014) M. E. Armstrong et al.   JOURNAL OF IMMUNOLOGY

Small silencing RNAs: State-of-the-art

(2009) Dirk Grimm   ADVANCED DRUG DELIVERY REVIEWS

MMSET is overexpressed in cancers: Link with tumor aggressiveness

(2009) Alboukadel Kassambara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis

(2009) Motoko Unoki et al.   BIOCHEMICAL PHARMACOLOGY

UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer

(2009) M Unoki et al.   BRITISH JOURNAL OF CANCER

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma

(2009) Shuhei Komatsu et al.   CARCINOGENESIS

Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors

(2009) R. Plummer et al.   CLINICAL CANCER RESEARCH

The promises and pitfalls of epigenetic therapies in solid tumours

(2009) Janet S. Graham et al.   EUROPEAN JOURNAL OF CANCER

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

(2009) Yanqi Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Phase I Biological Study of MG98, an Oligodeoxynucleotide Antisense to DNA Methyltransferase 1, in Patients with High-Risk Myelodysplasia and Acute Myeloid Leukemia

(2008) R. B. Klisovic et al.   CLINICAL CANCER RESEARCH

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

(2008) P. A.C. Cloos et al.   GENES & DEVELOPMENT

DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway

(2008) V Ullmannova-Benson et al.   LEUKEMIA

Deficiency of Mbd2 Attenuates Wnt Signaling

(2008) T. J. Phesse et al.   MOLECULAR AND CELLULAR BIOLOGY

Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia

(2008) C. J. Chou et al.   MOLECULAR CANCER THERAPEUTICS

Roles of the EZH2 histone methyltransferase in cancer epigenetics

(2008) Jeffrey A. Simon et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

(2008) Yutaka Kondo et al.   NATURE GENETICS

MBD2-Mediated Transcriptional Repression of the p14ARF Tumor Suppressor Gene in Human Colon Cancer Cells

(2008) Valérie Martin et al.   PATHOBIOLOGY

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography

(2008) D. A. Harki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE