Low-molecular-weight MK2 inhibitors: a tough nut to crack!

Inhibition of p38: Has the fat lady sung?

(2009) Mark C. Genovese   ARTHRITIS AND RHEUMATISM

Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

(2009) Frank Lovering et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting protein kinases for the development of anti-inflammatory drugs

(2009) Philip Cohen   CURRENT OPINION IN CELL BIOLOGY

Targeting innate immunity protein kinase signalling in inflammation

(2009) Matthias Gaestel et al.   NATURE REVIEWS DRUG DISCOVERY

Pyrrolo-pyrimidones: A novel class of MK2 inhibitors with potent cellular activity

(2008) Achim Schlapbach et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR studies of indole-based MK2 inhibitors

(2008) Zhaoming Xiong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MK2: a novel molecular target for anti-inflammatory therapy

(2008) Senthil Duraisamy et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

MK2 and MK3 - a pair of isoenzymes?

(2008) Natalia Ronkina   Frontiers in Bioscience-Landmark

Reduced Oxazolone-Induced Skin Inflammation in MAPKAP Kinase 2 Knockout Mice

(2008) Anne T. Funding et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Multiple and Single Binding Modes of Fragment-Like Kinase Inhibitors Revealed by Molecular Modeling, Residue Type-Selective Protonation, and Nuclear Overhauser Effects

(2008) Keith L. Constantine et al.   JOURNAL OF MEDICINAL CHEMISTRY

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

(2008) Tobias Thomas et al.   JOURNAL OF NEUROCHEMISTRY

Pyrazinoindolone inhibitors of MAPKAP-K2

(2007) D.R. Goldberg et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS