Article
Critical Care Medicine
Michael B. Weykamp, Katherine E. Stern, Scott C. Brakenridge, Bryce R. H. Robinson, Charles E. Wade, Erin E. Fox, John B. Holcomb, Grant E. O'Keefe
Summary: Although blood product resuscitation is favored, crystalloid resuscitation remains a common practice in prehospital care. This study investigated the relationship between prehospital crystalloid (PHC) volume and clinical outcomes, and found that higher PHC volume is associated with worse coagulopathy and increased risk of ARDS, but lower risk of AKI.
Article
Physiology
Yael Aschner, Kelly A. Correll, Keriann M. Beke, Daniel G. Foster, Helen M. Roybal, Meghan R. Nelson, Carly L. Meador, Matthew Strand, Kelsey C. Anderson, Camille M. Moore, Paul R. Reynolds, Katrina W. Kopf, Ellen L. Burnham, Gregory P. Downey
Summary: The study reveals that PTP alpha plays a crucial role in the fibroproliferative processes following acute lung injury, suggesting it could be a therapeutic target for improving long-term outcomes in ARDS patients.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alyssa Elmore, Ali Almuntashiri, Xiaoyun Wang, Sultan Almuntashiri, Duo Zhang
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening lung diseases. Surfactant protein-D (SP-D) has been extensively studied and found to have superior discriminatory ability for the diagnosis of ARDS. Recombinant SP-D shows potential as a drug for the treatment of ALI.
Article
Critical Care Medicine
Stephanie Arnold, Sajeel A. Shah, Simon J. Cleary, Blaze G. O'Shaughnessy, Richard T. Amison, Kate Arkless, Clive P. Page, Simon C. Pitchford
Summary: Intravascular hemolysis in disorders like sickle cell disease and malaria leads to inflammation and platelet activation. Research shows that introduction of whole or lysed red blood cells into the airways of mice triggers different levels of inflammatory responses, with potential involvement of platelets in inflammation modulation. A better understanding of the role platelets play in lung inflammation caused by red blood cells could offer new therapeutic approaches for conditions related to alveolar hemorrhage.
Review
Critical Care Medicine
Garrett L. Rampon, Steven Q. Simpson, Ritwick Agrawal
Summary: Prone positioning, initially proposed for improving gas exchange over 50 years ago, has been extensively studied and proven beneficial in various respiratory conditions, especially in severe ARDS patients. The ongoing COVID-19 pandemic has led to widespread use of prone positioning in awake, nonintubated patients with acute hypoxemic respiratory failure. Multiple clinical trials have been conducted to investigate the safety and effectiveness of prone positioning in these patients, further enhancing our understanding of its effects in respiratory failure.
Article
Critical Care Medicine
Xin Yuan, Peng Jiang, CongChao Qiao, Na Su, Pan Sun, Fangzhao Lin, Changqing Li
Summary: This study aimed to explore the effects of the platelet surface glycoprotein IIb/IIIa receptor antagonist tirofiban on coagulation and fibrinolytic abnormalities in a mouse model of antibody-mediated transfusion-associated acute lung injury (ALI). The results showed that tirofiban decreased lung injury indices and improved survival rates in the mouse model. Furthermore, tirofiban significantly reduced coagulation and fibrinolytic abnormalities compared to the model group.
Article
Medicine, Research & Experimental
Yaeko Hashimoto, Akifumi Eguchi, Yan Wei, Hiroyo Shinno-Hashimoto, Yuko Fujita, Tamaki Ishima, Lijia Chang, Chisato Mori, Takuji Suzuki, Kenji Hashimoto
Summary: This study investigated the impact of antibiotic-induced microbiome depletion on LPS-induced acute lung injury (ALI). The results showed that antibiotic treatment significantly attenuated LPS-induced lung injury and altered the diversity of the gut microbiota. Additionally, potential microbial markers and plasma metabolites associated with the ABX + LPS group were identified. Network analysis revealed correlations between IL-6 levels in bronchoalveolar lavage fluid (BALF) and specific gut microbes (or plasma metabolites).
Article
Respiratory System
H. James Ford, Wayne H. Anderson, Blair Wendlandt, Thomas Bice, Agathe Ceppe, Joyce Lanier, Shannon S. Carson
Summary: The study investigated the feasibility, safety, and efficacy of inhaled treprostinil in patients at risk for ARDS. Results showed that inhaled treprostinil did not improve the SpO2:F1O2 ratio compared to placebo, but drug-associated adverse events were not severe.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Medicine, General & Internal
Pierre Kalfon, Jean-Francois Payen, Alexandra Rousseau, Benjamin Chousterman, Marine Cachanado, Annick Tibi, Juliette Audibert, Francois Depret, Jean-Michel Constantin, Emmanuel Weiss, Francis Remerand, Yonathan Freund, Tabassome Simon, Bruno Riou
Summary: The study aimed to investigate the effect of almitrine on the need for mechanical ventilation in COVID-19 patients. The results showed that low-dose almitrine did not significantly reduce the risk of mechanical ventilation or death within 7 days.
Article
Respiratory System
Premila D. Leiphrakpam, Hannah R. Weber, Andrea McCain, Roser Romaguera Matas, Ernesto Martinez Duarte, Keely L. Buesing
Summary: This study successfully developed a novel large animal model to simulate smoke inhalation-induced ARDS, which could be beneficial for studying the pathophysiology of inhalation injury or developing new therapeutics.
RESPIRATORY RESEARCH
(2021)
Article
Biology
Parker S. Woods, Lucas M. Kimmig, Kaitlyn A. Sun, Angelo Y. Meliton, Obada R. Shamaa, Yufeng Tian, Renguel Cetin-Atalay, Willard W. Sharp, Robert B. Hamanaka, Goekhan M. Mutlu
Summary: Cellular metabolism plays a crucial role in regulating macrophage function. Changes in local oxygen concentration, such as those seen in conditions like acute respiratory distress syndrome (ARDS), can impact the metabolism and function of tissue-resident alveolar macrophages (TR-AMs), leading to their progressive loss which correlates with disease severity and mortality. Targeting cellular metabolism, particularly under hypoxic conditions, may hold therapeutic potential in improving outcomes in diseases characterized by acute inflammation.
Article
Medicine, General & Internal
Shikha Jha, Keval V. Patel, Amar Bukhari
Summary: The preeminent causes of blood transfusion-related morbidity and mortality are transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI). Differentiating between TACO and TRALI poses a challenge in terms of underlying etiology. This case report presents a unique presentation of acute respiratory distress in a 64-year-old female.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Physiology
Yi Xin, Maurizio Cereda, Nadir Yehya, Shiraz Humayun, Paolo Delvecchio, Jill M. Thompson, Kevin Martin, Hooman Hamedani, Paul Martorano, Ian Duncan, Stephen Kadlecek, Mehran Makvandi, Jacob S. Brenner, Rahim R. Rizi
Summary: Imatinib reduces mortality and lung injury severity in mechanically ventilated rats by attenuating pulmonary edema and inflammation. The drug decreases edema after lung injury and decreases capillary leak, leading to delayed injury progression. Therefore, pharmacological inhibition of edema may improve the severity and outcome of lung injury during mechanical ventilation.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Jan A. Graw, Victoria Buenger, Lorenz A. Materne, Alexander Krannich, Felix Balzer, Roland C. E. Francis, Axel Pruss, Claudia D. Spies, Wolfgang M. Kuebler, Steffen Weber-Carstens, Mario Menk, Oliver Hunsicker
Summary: This study investigated the effects of different storage durations of PRBCs on ARDS patients. The results showed that prolonged storage of PRBCs did not increase mortality in adults with ARDS, but transfusion of long-term stored PRBCs was associated with prolonged dependence on RRT in critically ill patients with ARDS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Andrew-Paul Deeb, Liling Lu, Frank X. Guyette, Andrew B. Peitzman, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Herb A. Phelan, Jason L. Sperry, Joshua B. Brown
Summary: This study found that prehospital crystalloid volumes between 250 and 1,250 mL are associated with lower mortality compared with lower or higher volumes, highlighting the importance of appropriate fluid resuscitation in hemorrhagic shock.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)