Article
Microbiology
Jonah Kupritz, Angelina Angelova, Thomas B. Nutman, Pedro H. Gazzinelli-Guimaraes
Summary: A comprehensive qualitative review and quantitative meta-analysis of 23 studies revealed that helminth infections dynamically shift the intestinal microbiome structure, with specific effects seen in soil-transmitted helminth species on the microbiome composition.
Article
Gastroenterology & Hepatology
Manasi Agrawal, Kristine H. H. Allin, Aske T. T. Iversen, Saurabh Mehandru, Jean-Frederic Colombel, Tine Jess
Summary: According to this study, early-life exposure to mebendazole is associated with increased risk of adult-onset UC, but not Crohn's disease. This suggests the importance of early-life exposures in shaping the risk of IBD later in life.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biodiversity Conservation
Anuja Sharma, Shilpa Sharma, Shilippreet Kour, Achhada Ujalkaur Avatsingh, Kahkashan Perveen, Jamilah A. Alsulami, Nasib Singh
Summary: The prevalence of gastrointestinal parasites in small and large ruminants in northern India's agro-climatic region is high, especially during the rainy season. The study emphasizes the need for preventive and control strategies for effective animal health management.
Article
Microbiology
Bo-bo Wang, Feng-hui Wang, Yu-jue Wang, Yi-bo Jia, Shu-yue Tian, Xi-chen Zhang, Ya-juan Xue, You-lei Li, Kui-zheng Cai
Summary: This study investigates the morphological and structural differences of different types of chlamydospores of Arthrobotrys flagrans, a nematophagous fungus. The research provides insights into the biological control of parasitic nematodiasis. The study examines the characteristics of dormant and non-dormant chlamydospores through optical and electron microscopy, as well as various staining methods. The findings indicate changes in the cell wall and intracellular materials of the spores after entering dormancy.
JOURNAL OF BASIC MICROBIOLOGY
(2023)
Article
Microbiology
Yu Zhang, Xin Wang, Yuan Ran, Ke-Qin Zhang, Guo-Hong Li
Summary: This study reveals the functions of the LaeA gene in A. flagrans, including mycelial growth, spore production, pathogenicity, secondary metabolism, and energy metabolism. Additionally, protein-protein interactions between AfLaeA and other eight proteins were detected. These findings are important for understanding the regulatory role of AfLaeA in A. flagrans and developing efficient nematode biocontrol agents.
MICROBIOLOGY SPECTRUM
(2023)
Article
Genetics & Heredity
Gabrielle M. Becker, Joan M. Burke, Ronald M. Lewis, James E. Miller, James L. M. Morgan, Benjamin D. Rosen, Curtis P. Van Tassell, David R. Notter, Brenda M. Murdoch
Summary: Gastrointestinal nematodes pose a severe threat to sheep production. Drug resistance and environmental concerns have led to the exploration of alternative control methods. This study identified genetic variants associated with resistance to nematode infection in Katahdin sheep, providing insights into the genetic mechanisms of host response to nematodes.
FRONTIERS IN GENETICS
(2022)
Review
Chemistry, Medicinal
Cal Koger-Pease, Dilhan J. J. Perera, Momar Ndao
Summary: Despite the devastating impact and widespread occurrence of parasitic diseases globally, vaccines against parasites have been slower to develop compared to vaccines against viral and bacterial infections. One of the main challenges is the lack of vaccine strategies that can induce the complex and multifaceted immune responses required to eliminate parasitic persistence. Adenovirus (AdV) vectors have emerged as a potential solution for complex diseases like parasitic infections by driving CD8+ T cell responses, which are known to be important in immunity against many parasitic organisms. This review discusses recent advances in AdV-vectored vaccines targeting five major human parasitic diseases: malaria, Chagas disease, schistosomiasis, leishmaniasis, and toxoplasmosis. The use of AdV-vectored vaccines shows promise in tackling the historically challenging goal of developing vaccines for parasitic diseases.
Article
Multidisciplinary Sciences
Le Yang, Xuemei Li, Meihua Xie, Na Bai, Jiangliu Yang, Kexin Jiang, Ke-Qin Zhang, Jinkui Yang
Summary: The three orthologous Ras GTPases in A. oligospora have pleiotropic roles in regulating mycelial growth, conidiation, stress resistance, and pathogenicity, as well as affecting mitochondrial activity, autophagy, and secondary metabolite biosynthesis. Transcriptome and metabolic analyses revealed their involvement in signal transduction, energy production, and the biosynthesis of secondary metabolites, providing insights into their essential roles in vegetative growth, development, and pathogenicity in nematode-trapping fungi.
Article
Multidisciplinary Sciences
Xinlei Yan, Wenying Han, Xindong Jin, Yufei Sun, Jialu Gao, Xiuli Yu, Jun Guo
Summary: The study found that koumiss has a certain effect on preventing and treating Toxoplasma gondii infection. Koumiss treatment can reduce the number of brain cysts and increase the abundance of certain bacteria associated with preventing T. gondii infection. Moreover, koumiss can inhibit or ameliorate T. gondii infection by regulating unique metabolic pathways.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Tad A. Dallas, Pedro Jordano
Summary: This study examined the conservation of species' roles in host-parasite networks using a global occurrence database of helminth parasites, finding that the majority of species' roles are not conserved. This suggests that species' roles may be influenced by spatial and environmental gradients, as well as the context of the local host and helminth parasite community.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Infectious Diseases
Katharina Stracke, Poom Adisakwattana, Suparat Phuanukoonnon, Tippayarat Yoonuan, Akkarin Poodeepiyasawat, Paron Dekumyoy, Kittipong Chaisiri, Alexandra Roth Schulze, Stephen Wilcox, Harin Karunajeewa, Rebecca J. Traub, Aaron R. Jex
Summary: Soil-transmitted helminth infections have a significant negative impact on global population health, especially affecting children disproportionately. The lack of infection prevalence data in many endemic regions highlights the importance of molecular tools for establishing accurate epidemiological profiles. The gut microbiota can be influenced by medication, lifestyle factors, and co-inhabitation with parasites, but baseline studies in this area are limited.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Meihua Xie, Ni Ma, Na Bai, Meichen Zhu, Ke-Qin Zhang, Jinkui Yang
Summary: This study elucidates the diverse functions of phospholipase C in Arthrobotrys oligospora, including its role in the development of hyphae, spores, and cell nuclei, responses to stress, formation of traps, and predation of nematodes. The study also highlights the involvement of phospholipase C in the biosynthesis of secondary metabolites and regulation of trap morphogenesis in nematode-trapping fungi.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Parasitology
Peter Halvarsson, Paulius Baltrusis, Petter Kjellander, Johan Hoglund
Summary: By investigating the community structure of parasitic intestinal nematodes in four wildlife hosts in Sweden, this study found that the majority of identified parasite species were specific to wildlife. The potential for cross-infections of nematodes between wildlife and domestic sheep appears to be relatively low, although not completely negligible.
PARASITES & VECTORS
(2022)
Review
Medicine, Research & Experimental
Zahra Alizadeh, Mahmoud Mahami-Oskouei, Adel Spotin, Ehsan Ahmadpour, Pengfei Cai, Siamak Sandoghchian Shotorbani, Fariba Pashazadeh, Fereshteh Ansari, Hamed Mohammadi
Summary: In this systematic review, the presence of miRNAs in helminth parasites has been comprehensively summarized, and their potential applications in diagnosing and controlling parasitic infections have been discussed. Functional studies on miRNAs derived from helminth parasites have also been presented.
CURRENT MOLECULAR MEDICINE
(2022)
Article
Zoology
Aline Aguiar, Drausio Honorio Morais, Lidiane A. Firmino Silva, Luciano Alves Dos Anjos, Ottilie Carolina Foster, Reinaldo Jose Da Silva
Summary: The study presents the richness of metazoan endoparasites associated with 25 anuran species in a transitional area between Cerrado and Atlantic Rain Forest from Brazil, detailing the types, quantities, prevalence, and distribution among host populations of these parasites.
Article
Biotechnology & Applied Microbiology
J. A. Hernandez, C. F. Cazapal-Monteiro, F. L. Arroyo, M. I. Silva, A. M. Palomero, A. Paz-Silva, R. Sanchez-Andrade, M. S. Arias
BIOLOGICAL CONTROL
(2018)
Article
Parasitology
Jose Angel Hernandez, Rita Sanchez-Andrade, Cristiana Filipa Cazapal-Monteiro, Fabian Leonardo Arroyo, Jaime Manuel Sanchis, Adolfo Paz-Silva, Maria Sol Arias
PARASITES & VECTORS
(2018)
Article
Biotechnology & Applied Microbiology
A. M. Palomero, J. A. Hernandez, C. F. Cazapal-Monteiro, Fabian Arroyo Balan, M. I. Silva, Adolfo Paz-Silva, R. Sanchez-Andrade, Maria Sol Arias Vazquez
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Parasitology
A. M. Palomero, C. F. Cazapal-Monteiro, E. Valderrabano, A. Paz-Silva, R. Sanchez-Andrade, M. S. Arias
Article
Parasitology
Mathilde Voinot, Cristiana Cazapal-Monteiro, Jose Angel Hernandez, Antonio Miguel Palomero, Fabian Leonardo Arroyo, Jaime Sanchis, Jose Pedreira, Rita Sanchez-Andrade, Adolfo Paz-Silva, Maria Sol Arias
VETERINARY PARASITOLOGY
(2020)
Article
Parasitology
A. Quigley, M. Sekiya, A. Garcia-Campos, A. Paz-Silva, A. Howell, D. J. L. Williams, G. Mulcahy
VETERINARY PARASITOLOGY
(2020)
Review
Parasitology
M. Canhao-Dias, A. Paz-Silva, L. M. Madeira de Carvalho
VETERINARY PARASITOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Antonio M. Palomero, Cristiana F. Cazapal-Monteiro, Candido Vina, Jose A. Hernandez, Mathilde Voinot, Maria Vila, Maria I. Silva, Adolfo Paz-Silva, Rita Sanchez-Andrade, Maria Sol Arias
Summary: Two different formulations containing a blend of spores of Mucor circinelloides and Duddingtonia flagrans were tested on wapitis, showing significant reduction of trichostrongylids egg-output without any observed adverse effects, indicating their potential for long-term control of trichostrongylid infection in wild captive animals.
BIOLOGICAL CONTROL
(2021)
Article
Agriculture, Dairy & Animal Science
Sergio Ramalho Sousa, Sofia Anastacio, Miguel Novoa, Adolfo Paz-Silva, Luis Manuel Madeira de Carvalho
Summary: The study focused on parasitic control in Miranda donkeys in northeastern Portugal, with targeted selective treatment reducing deworming frequency and parasite prevalence, but also resulting in a decrease in parasite biodiversity.
Article
Microbiology
Candido Vina, Maria Isabel Silva, Antonio Miguel Palomero, Mathilde Voinot, Maria Vila, Jose Angel Hernandez, Adolfo Paz-Silva, Rita Sanchez-Andrade, Cristiana Filipa Cazapal-Monteiro, Maria Sol Arias
Article
Microbiology
Mathilde Voinot, Rodrigo Bonilla, Sergio Sousa, Jaime Sanchis, Miguel Canhao-Dias, Jose Romero Delgado, Joao Lozano, Rita Sanchez-Andrade, Maria Sol Arias, Luis Madeira de Carvalho
Summary: The study demonstrates that integrating efficient anthelmintic deworming with rotational pasturing and regular intake of chlamydospores of M. circinelloides and D. flagrans helps maintain low levels of strongyle egg output in first-season grazing ewe lambs and improves their health status. The control groups showed an increase in strongyle egg output throughout the study, reaching over 600 eggs per gram of feces, while the experimental groups decreased to below 250 eggs per gram.
Article
Microbiology
Candido Vina, Rami Salmo, Maria Vila Pena, Antonio Miguel Palomero, Jose Angel Hernandez, Cristiana Cazapal-Monteiro, Maria Sol Arias, Rita Sanchez-Andrade, Adolfo Paz-Silva
Summary: Feeding shelter dogs with gelatin containing parasiticide fungi can effectively reduce the risk of helminth infection.
