Pharmacokinetic basis of the antiplatelet action of prasugrel

Effect of proton pump inhibitors on clinical outcome in patients treated with clopidogrel: a systematic review and meta-analysis

(2010) J. M. SILLER-MATULA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Proton Pump Inhibitor and Clopidogrel Interaction: Fact or Fiction?

(2009) Loren Laine et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel

(2009) Jessica L. Mega et al.   CIRCULATION

Comparing the antiplatelet effect of clopidogrel hydrogensulfate and clopidogrel besylate: a crossover study

(2009) Horst Neubauer et al.   Clinical Research in Cardiology

Comparison of Human Cytochrome P450 Inhibition by the Thienopyridines Prasugrel, Clopidogrel, and Ticlopidine

(2009) Katsunobu Hagihara et al.   Drug Metabolism and Pharmacokinetics

P2Y12 inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use

(2009) L. Wallentin   EUROPEAN HEART JOURNAL

Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease

(2009) C. Varenhorst et al.   EUROPEAN HEART JOURNAL

Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome

(2009) P. Michael Ho   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolism and Disposition of the Thienopyridine Antiplatelet Drugs Ticlopidine, Clopidogrel, and Prasugrel in Humans

(2009) Nagy A. Farid et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials

(2009) Michelle L O'Donoghue et al.   LANCET

Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial

(2009) Gilles Montalescot et al.   LANCET

Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs

(2009) K. Hagihara et al.   XENOBIOTICA

Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel

(2008) Jolanta M. Siller-Matula et al.   AMERICAN HEART JOURNAL

Tailored Clopidogrel Loading Dose According to Platelet Reactivity Monitoring to Prevent Acute and Subacute Stent Thrombosis

(2008) Laurent Bonello et al.   AMERICAN JOURNAL OF CARDIOLOGY

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

(2008) Ulrich M. Zanger et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Greater Clinical Benefit of More Intensive Oral Antiplatelet Therapy With Prasugrel in Patients With Diabetes Mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis in Myocardial Infarction 38

(2008) Stephen D. Wiviott et al.   CIRCULATION

Dose Effect of Clopidogrel Reloading in Patients Already on 75-mg Maintenance Dose

(2008) Jean-Philippe Collet et al.   CIRCULATION

Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel

(2008) David S. Small et al.   CURRENT MEDICAL RESEARCH AND OPINION

Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel

(2008) Y. Nishiya et al.   DRUG METABOLISM AND DISPOSITION

Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial

(2008) S. A. Murphy et al.   EUROPEAN HEART JOURNAL

Influence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin

(2008) Martine Gilard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents

(2008) Dietmar Trenk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12receptor

(2008) I. ALGAIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

(2008) Jean-Philippe Collet et al.   LANCET

Prasugrel, a New Thienopyridine Antiplatelet Drug, Weakly Inhibits Cytochrome P450 2B6 in Humans

(2007) Nag A. Farid et al.   JOURNAL OF CLINICAL PHARMACOLOGY