Article
Oncology
Yuzhuo Wang, Xiucheng Liu, Zhixiang Chao, Xichun Qin, Xiaoyu Quan, Zhiwei Liu, Yeqing Zhou, Caili Jia, Hao Qin, Hao Zhang
Summary: This study demonstrated the protective role of PEDF in endothelial tight junctions and the vascular barrier during acute myocardial infarction (AMI). PEDF maintained the expression of TJ proteins and endothelial barrier integrity by inhibiting the classical Wnt pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hunghao Chu, Ivan T. Rebustini, S. Patricia Becerra, Yadong Wang
Summary: In this study, the amino acid sequence of PEDF was modified to increase its affinity for heparin and hyaluronic acid, leading to improved retention in the retina microenvironment. The engineered PEDF exhibited antiangiogenic and retinal survival bioactivities, making it a potential therapeutic drug for retinal diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Physiology
Alexandra Bernardo-Colon, Miriam Lerner, S. Patricia Becerra
Summary: The study revealed that PEDF can reduce the production and secretion of IL-6 in RPE cells, decrease cell death induced by TNF-α, demonstrating its anti-inflammatory effects. The pro-survival domain in PEDF plays a key role in blocking IL-6, highlighting its potential as a novel antagonist in managing retinal disease-related inflammation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fan Qiu, Bo Jiang, Yangui Lin, Huaming Li, Dan Li, Min Luo, Hongliang Hui, Haoran Miao, Yiqian Zhang
Summary: The combined use of PEDF and HGF can effectively treat PH by inhibiting angiogenesis and reducing vascular permeability. PEDF targets VEGFR2 and suppresses its phosphorylation at specific sites, leading to enhanced therapeutic efficacy of HGF. This study provides new insights into treatment strategies for clinical PH.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Lei Xi
Summary: Ocular ischemia is a vision-threatening disease associated with various ocular diseases. This study investigated the effects of pigment epithelium derived factor (PEDF) and anti-vascular endothelial growth factor (anti-VEGF) therapy, as well as their combined use, on an ex vivo ischemic rat eye model. The results showed that the combination of PEDF and anti-VEGF significantly reduced the staining intensity of VEGF and GFAP, and decreased the number of TUNEL-positive nuclei, indicating its potential as a therapeutic strategy for ischemic retinal and choroidal diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Cuiliu Li, Yunna Zhang, Fang Gao, Nairui Zhao, Guangya Wang, Jinxiu Xu, Xiaopeng Zhao
Summary: This study investigated the sexual dimorphism of serum PEDF and its influencing factors in healthy individuals. The findings showed that there was no significant difference in serum PEDF levels between men and women overall, but men under 50 years old had significantly higher levels compared to women. In women, serum PEDF levels were significantly higher in those aged 50 years and over compared to those younger than 50. Correlation analysis revealed that serum PEDF levels in women were significantly correlated with various metabolic indices, suggesting that elevated triacylglycerol and aminotransferase levels, as well as decreased estradiol, were important predictors of increased PEDF concentrations.
Review
Immunology
Ting He, Wei Liu, Chuan-an Shen
Summary: Inflammation is a biological response to harmful stimuli, and excessive inflammation can lead to various diseases. PEDF, as a glycoprotein, participates in inflammatory-related diseases, but the mechanism remains unclear. PEDF exerts its anti-inflammatory effects through various pathways, suggesting its potential as a therapeutic target for inflammatory disorders.
EUROPEAN JOURNAL OF INFLAMMATION
(2022)
Article
Ophthalmology
Shu-I Yeh, Sung-Hsun Yu, Hsiao-Sang Chu, Chin-Te Huang, Yeou-Ping Tsao, Chao-Min Cheng, Wei-Li Chen
Summary: The study investigated the potential of PEDF peptide 44-mer in promoting nerve regeneration in a rabbit corneal nerve injury model and its neurotrophic ability in cultivated mouse trigeminal neuron cells. The results demonstrated that 44-mer could promote corneal nerve regeneration in vivo and had neurotrophic effects in vitro.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Victoria H. Ko, Lumeng J. Yu, Jordan D. Secor, Amy Pan, Paul D. Mitchell, Hiroko Kishikawa, Mark Puder
Summary: The study showed that the downregulation of PEDF is the primary mechanism by which Roxadustat accelerates CLG, highlighting the critical role PEDF may have in pulmonary growth and development, previously unexplored field.
Article
Endocrinology & Metabolism
Serena Low, Sharon Pek, Angela Moh, Keven Ang, Jonathon Khoo, Yi-Ming Shao, Wern E. Tang, Ziliang Lim, Tavintharan Subramaniam, Chee F. Sum, Su C. Lim
Summary: Higher TyG index independently predicted CKD progression in Type 2 Diabetes Mellitus (T2DM). The association between TyG index and CKD progression was mediated by pigment epithelium-derived factor (PEDF).
DIABETES & VASCULAR DISEASE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wei Shi, Jiuhui Li, Jiaqi Zhou, Yuanyuan Li, Haiyan Lin, Hai Qian, Wen Fan
Summary: The PEDF-derived peptide compound G24 designed and synthesized in this study showed potential as a novel angiogenesis inhibitor for diabetic retinopathy treatment, exhibiting significant effects on inhibiting angiogenesis and cell migration in vitro, as well as strong inhibitory effects on cell apoptosis and endothelial cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Xue Tian, Yingting Zuo, Shuohua Chen, Qian Liu, Boni Tao, Shouling Wu, Anxin Wang
Summary: The study found that elevated levels of baseline and long-term TyG index are associated with an increased risk of myocardial infarction, with a stronger association in women. This suggests that the TyG index may be useful for identifying individuals at high risk of developing MI.
CARDIOVASCULAR DIABETOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Zhongjie Fu, Lois E. H. Smith
Summary: Pathologic angiogenesis in eye diseases leading to blindness can be attributed to cell senescence, as demonstrated by the bioinformatics study conducted by Crespo-Garcia, Tsuruda, and Dejda. Their findings were validated in human and mouse retina models, where clearance of senescent cells effectively suppressed neovessel growth.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Yuzhuo Wang, Xiucheng Liu, Xiaoyu Quan, Xichun Qin, Yeqing Zhou, Zhiwei Liu, Zhixiang Chao, Caili Jia, Hao Qin, Hao Zhang
Summary: Microvascular diseases are clinically important, and vascular abnormalities play a central role in their development. PEDF is a substance that inhibits angiogenesis and also has neurotrophic effects. This study reviews the expression levels of PEDF in common microvascular diseases, its effects on the vasculature and nerves, and summarizes various PEDF agents and their potential as therapeutic options.
Article
Biotechnology & Applied Microbiology
Mohamed A. Faynus, Jeffrey K. Bailey, Britney O. Pennington, Mika Katsura, Duncan A. Proctor, Ashley K. Yeh, Sneha Menon, Dylan G. Choi, Jane S. Lebkowski, Lincoln Johnson, Dennis O. Clegg
Summary: Dry age-related macular degeneration (AMD) is a common eye disease with no current treatment options. Using microcarrier technology for cell culture allows efficient large-scale production of therapeutic retinal pigmented epithelial cells, fulfilling the treatment demands.
BIOENGINEERING-BASEL
(2022)