Article
Engineering, Biomedical
In-Kyu Lee, Ruosen Xie, Agustin Luz-Madrigal, Seunghwan Min, Jingcheng Zhu, Jiahe Jin, Kimberly L. Edwards, M. Joseph Phillips, Allison L. Ludwig, David M. Gamm, Shaoqin Gong, Zhenqiang Ma
Summary: Age-related macular degeneration (AMD) can lead to blindness by causing the loss of retinal pigment epithelium (RPE) and photoreceptors (PRs), which are the outermost layers of the retina. To reconstruct the outer retina, especially in later stage AMD and other macular dystrophies, scaffolds have been developed. Microfabricated, honeycomb-patterned, biodegradable poly(glycerol sebacate) (PGS) scaffolds were created to deliver organized layers of RPE and PRs to the subretinal space, and an optimized process was developed to shorten scaffold production time. These scaffolds successfully supported the seeding of human pluripotent stem cell-derived RPE and PRs, either separately or as a dual cell-layered construct. They have the potential to accelerate retinal cell transplantation efforts and benefit patients with AMD and other retinal degenerative diseases.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Jianing Yan, Xixia Liu, Jingyi Liu, Xinjie Zhang, Qiang Zheng, Junjie Nan, Mengjia Lin, Haoqi Pan, Yifan Wang, Xiujun Cai, Jun Yin
Summary: A dual-layer tubular scaffold was fabricated to support bile duct regeneration, providing adequate mechanical strength and biocompatibility, showing superior results in animal models.
MATERIALS & DESIGN
(2021)
Article
Engineering, Environmental
Jian Cao, Jiahe Wu, Jiafu Mu, Lingmin Lin, Xunqi Zhang, Tianchen Huang, Teng Ma, Manning Zhu, Xiaoyang Dai, Xuhua Wang, Shiqing Feng, Jian-Qing Gao
Summary: Implanting MSCs in SCI repair holds promise, but the harsh environment and excessive ROS threaten MSC survival. The dual-phase pathology of acute and chronic phases makes it challenging to alleviate severe inflammation and promote functional recovery. The RF-pGel-MS scaffold system efficiently scavenges ROS and boosts stem cell therapeutics, showing significant efficacy in locomotor and electro-physiology recovery in SCI rats.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Liaobing Xin, Xiaowen Zheng, Jianmin Chen, Sentao Hu, Yilun Luo, Qunzi Ge, Xiaoying Jin, Lie Ma, Songying Zhang
Summary: This study explores an acellular biomaterial called SDF-1 alpha/E7-modified collagen scaffold (CES), which enables near-complete endometrium regeneration and fertility restoration by mobilizing endogenous MSCs. The results demonstrate that CES can overcome the traditional limitations of cell-based therapies and serve as a clinically feasible and cell-free strategy with high therapeutic efficiency for IUA treatment.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Shuangpeng Jiang, Guangzhao Tian, Zhen Yang, Xiang Gao, Fuxin Wang, Juntan Li, Zhuang Tian, Bo Huang, Fu Wei, Xinyu Sang, Liuqi Shao, Jian Zhou, Zhenyong Wang, Shuyun Liu, Xiang Sui, Quanyi Guo, Weimin Guo, Xu Li
Summary: This study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. The promoting effect may be related to the polarization of macrophages and inhibition of inflammatory response by hWJMSC-Exos. Additionally, hWJMSC-Exos contain miRNAs that can promote hyaline cartilage regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
W. Benton Swanson, Maiko Omi, Seth M. Woodbury, Lindsey M. Douglas, Miranda Eberle, Peter X. Ma, Nan E. Hatch, Yuji Mishina
Summary: This study investigated the impact of scaffold pore curvature on the differentiation trajectory of mesenchymal stem cells (MSCs), demonstrating that the curvature of scaffold pores can influence cell aggregation and differentiation by altering the cytoskeleton, ultimately guiding cell fate specification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell Biology
Ali Salehi, Mohammad A. Mobarhan, Javad Mohammadi, Hosein Shahsavarani, Mohammad Ali Shokrgozar, Atefeh Alipour
Summary: The study investigated the characteristics of decellularized cabbage leaves and their potential for promoting bone differentiation, as demonstrated by enhanced osteogenic differentiation of BM-MSCs on the scaffold. These results suggest that decellularized cabbage leaves have great potential for tissue engineering applications in bone regeneration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Babitha Sumathy, Shiny Velayudhan
Summary: This study introduces a novel method for incorporating hair follicle derived stem cells in micro-pits of a bilayer skin equivalent using microneedles and a gelatin based scaffold. The microneedles are able to penetrate the upper layer of the scaffold and reach the lower layer, mimicking the natural niche of hair follicle stem cells. The bilayer system consists of electrospun layers that represent the epidermis and dermis, resulting in the formation of a complete skin model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Ceramics
Patricia Ros-Tarraga, Carlos M. Martinez, Miguel A. Rodriguez, Piedad N. De Aza
Summary: The elderly population is increasing, leading to an increase in bone and joint problems. Scaffold for bone tissue regeneration can solve these problems, and material selection is crucial for satisfactory results. This study designed a three-dimensional porous ceramic scaffold and analyzed its biocompatibility and osteoinductive capacity. The results suggest that it has potential applications as bone substitutes.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Yucong Li, Linlong Li, Ye Li, Lu Feng, Bin Wang, Ming Wang, Haixing Wang, Meiling Zhu, Yongkang Yang, Erik I. Waldorff, Nianli Zhang, Ingmar Viohl, Sien Lin, Liming Bian, Wayne Yuk-Wai Lee, Gang Li
Summary: In this study, a new tissue engineering strategy for cartilage defect treatment was proposed using an injectable self-healing adhesive hydrogel and pulsed electromagnetic field (PEMF) treatment. The results demonstrated the superior clinical potential of this strategy in promoting chondrogenesis and cartilage repair.
BIOACTIVE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Xinlan Ge, Dabin Xu, Ke Pan, Guankun Mao, Shichun Lu, Chonghui Li
Summary: A new mouse model of bile duct injury and repair was successfully established, providing a reliable model for studying biliary repair mechanisms and tissue engineering of biliary ducts.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Chemistry, Applied
Katherine A. Pitrolino, Reda M. Felfel, Laura Macri Pellizzeri, Jane McLaren, Alexander A. Popov, Virginie Sottile, Colin A. Scotchford, Brigitte E. Scammell, George A. F. Roberts, David M. Grant
Summary: An innovative multi-layered chitosan scaffold was developed for repairing osteochondral defects, with a distinct gradient of pore size and the addition of nanohydroxyapatite for strength. The scaffold exhibited good mechanical performance under loading, supported attachment and proliferation of human mesenchymal stem cells, and facilitated osteogenic and chondrogenic differentiation in specific layers.
CARBOHYDRATE POLYMERS
(2022)
Review
Polymer Science
Antony V. V. Samrot, Mahendran Sathiyasree, Sadiq Batcha Abdul Rahim, Robinson Emilin Renitta, Kasirajan Kasipandian, Sivasuriyan Krithika Shree, Deenadhayalan Rajalakshmi, Nagarajan Shobana, Shanmugaboopathi Dhiva, Sasi Abirami, Sridevi Visvanathan, Basanta Kumar Mohanty, Gokul Shankar Sabesan, Suresh V. Chinni
Summary: Biological macromolecules, such as polysaccharides, proteins, and glycoproteins, have been widely used in tissue engineering due to their ability to mimic the extracellular matrix and their biocompatibility. Scaffolds made from these macromolecules have properties like tensile strength, biodegradability, and flexibility. This review discusses the fabrication methods and applications of scaffolds using various biological macromolecules and emphasizes the importance of natural polymers over synthetic ones due to their unique properties.
Article
Pharmacology & Pharmacy
Asma Sepahdar, Abolfazl Nazbar, Saeed Bahadorikhalili, Ghassem Rezaei, Mohammad Ali Shokrgozar, Mohammad Mehdi Dehghan, Hamid Akbari Javar, Shahin Bonakdar
Summary: This paper presents a novel composite scaffold for the regeneration of cartilage tissue. The scaffold is made of a combination of a hydrogel and a controlled release drug delivery system. The release of kartogenin, a chondrogenic-inducing drug, from the scaffold is successfully controlled. The scaffold also demonstrates a porous structure and shows good performance in inducing chondrogenic differentiation of stem cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
