Article
Engineering, Biomedical
Samuel A. Hockett, John T. Sherrill, Micah Self, Simon C. Mears, C. Lowry Barnes, Erin M. Mannen
Summary: This study found that augmentation of a core decompression tract does not improve mechanical properties in a synthetic bone model, but may be protective against subtrochanteric fractures.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
James Bielenstein, Milena Radenkovic, Stevo Najman, Luo Liu, Yanru Ren, Baoyi Cai, Florian Beuer, Denis Rimashevskiy, Reinhard Schnettler, Said Alkildani, Ole Jung, Franziska Schmidt, Mike Barbeck
Summary: This study analyzes the in vivo responses to xenogeneic and synthetic bone substitute granules, revealing differences in bone regeneration and immune response. The synthetic BSM induces a higher pro-inflammatory response, while the xenogeneic BSM induces a higher anti-inflammatory reaction. However, both materials show comparable bone regeneration. The results demonstrate the biocompatibility of the synthetic BSM maxresorb (R) and suggest it as a suitable alternative to natural BSM for various indications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Chi Ma, Graham Andre, David Edwards, Harry K. W. Kim
Summary: The study successfully established a clinically relevant model of osteonecrosis on rats, which can be used for efficient and cost-effective testing of new treatment strategies. The model mimicked the pathological features and progression of osteonecrosis in humans, making it a valuable tool for the development and testing of innovative biological therapeutics.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Multidisciplinary
A. M. Lopera-Echavarria, Daniela Medrano-David, Angela M. Lema-Perez, Pedronel Araque-Marin, Martha E. Londono
Summary: A new methodology was proposed to evaluate the behavior of bone substitutes in a confined bone environment, assessing their bioactivity, stability, and cytotoxicity. The bone substitute showed bioactivity and apatite formation in simulated body fluid, with a high swelling rate but maintained stability during degradation testing. Cytotoxicity evaluation showed no harmful effects on cells.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Biophysics
Victoria L. Abdo, Lina J. Suarez, Lucca Gomes de Paula, Raphael C. Costa, Jamil Shibli, Magda Feres, Valentim A. R. Bara, Martinna Bertolini, Joao Gabriel Silva Souza
Summary: This study investigates the issue of microbial contamination of resorbable membranes, finding that different types of bacteria colonize the exposed membrane surface, thereby affecting the effectiveness of bone regeneration therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Physical
Matej Tomas, Marija Candrlic, Martina Juzbasic, Zrinka Ivanisevic, Nikola Matijevic, Aleksandar Vcev, Olga Cvijanovic Peloza, Marko Matijevic, Zeljka Peric Kacarevic
Summary: This article systematically reviewed the effect of injectable synthetic biomaterials on new bone formation in the maxilla and mandible in animals and humans. It found heterogeneity in animal and human studies, indicating the need for further research to better understand the advantages and disadvantages of these biomaterials.
Article
Engineering, Biomedical
Haoyuan Lei, Zhigang Zhou, Lei Liu, Canyu Gao, Zixuan Su, Zhen Tan, Pin Feng, Ming Liu, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: In this study, an icariin-loaded 3D-printed porous Ti6Al4V reconstruction rod was developed and its mechanical and biological efficacy were verified through in vitro and in vivo experiments. The results demonstrated that the reconstruction rod facilitated osteogenesis and neovascularization, providing a positive therapeutic effect for early avascular necrosis of the femoral head.
ACTA BIOMATERIALIA
(2023)
Review
Surgery
Kyle N. Kunze, Spencer W. Sullivan, Benedict U. Nwachukwu
Summary: Osteonecrosis of the femoral head is caused by interrupted circulation and can be either traumatic or non-traumatic. Common symptoms include pain and limited hip mobility, with diagnosis confirmed through imaging. Treatment options include conservative measures, therapeutic methods, and surgical intervention. In recent years, arthroscopy-assisted core decompression has shown promising outcomes.
FRONTIERS IN SURGERY
(2022)
Article
Engineering, Biomedical
Yajie Lu, Xiantao Chen, Xiao Lu, Changning Sun, Minghui Li, Guojing Chen, Zuoyao Long, Yuan Gao, Haoqiang Zhang, Mengquan Huang, Chuanlei Ji, Hongbin Fan, Dong Liu, Yuewen Hao, Hong Wang, Leilei Zhang, Hongmei Zhang, Jianxi Lu, Zhen Wang, Jing Li
Summary: This study proposed a beta-TCP system for treating avascular necrosis of the femoral head (ANFH) by promoting revascularization and bone regeneration. The study revealed and quantified the angio-conductive properties and concurrent osteogenesis of the highly interconnected porous beta-TCP scaffold using an in vivo model. Mechanical test and analysis showed that the mechanical loss caused by tissue necrosis and surgery was compensated after implantation, leading to adaptive strength increase and bone regeneration.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
C. Vaquette, J. Mitchell, T. Fernandez-Medina, S. Kumar, S. Ivanovski
Summary: The study demonstrates that a highly porous, resorbable scaffold fabricated using additive manufacturing techniques enables reproducible extra-skeletal bone formation and prevents bone resorption. Additionally, it shows that additively manufactured biphasic scaffolds functionalized with BMP-2 facilitate dimensionally stable bone regeneration that supports dental implant osseointegration.
Article
Medicine, General & Internal
Elio Minetti, Gianna Dipalma, Andrea Palermo, Assunta Patano, Alessio Danilo Inchingolo, Angelo Michele Inchingolo, Francesco Inchingolo
Summary: The purpose of this research was to assess the effectiveness of a medical device that can extract tooth graft materials from the patient's own teeth. Twenty patients underwent tooth extraction and preservation, using the extracted tooth as graft material. Results showed successful bone regeneration and no complications during the healing phase.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Winston Adam Camargo, Jan Willem Hoekstra, John A. Jansen, Jeroen J. J. P. van den Beucken
Summary: In this study, the effect of alendronate (ALN) treatment on bone defect regeneration in osteoporotic rats was evaluated. The results showed that oral administration of ALN can enhance bone formation in the defects, increasing it to 10 times compared to the non-treated group. Additionally, Bio-Oss(R) was found to be an effective bone substitute, promoting bone formation in both healthy and osteoporotic conditions. The study highlights the beneficial effects of oral ALN in mitigating the adverse effects of osteoporosis on bone defect regeneration.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Orthopedics
Ting-Yi Lin, Chun-Wei Fu, Pei-Shan Tsai, Chang-Hung Huang, Shun-Hua Wei, Min-Yao Chuang
Summary: The study aimed to determine the impact of avascular necrosis on the clinical outcomes and union incidence after arthroscopic bone grafting for the treatment of scaphoid nonunion. The results showed that arthroscopic bone grafting had good union rates and satisfactory outcomes regardless of the presence of avascular necrosis.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Materials Science, Biomaterials
Isabel Pereira, Jose Eduardo Pereira, Luis Maltez, Alexandra Rodrigues, Catarina Rodrigues, Manuela Oliveira, Dina M. Silva, Ana Rita Caseiro, Justina Prada, Ana Colette Mauricio, Jose Domingos Santos, Miguel Gama
Summary: The development of injectable bone substitutes is important for addressing inaccessible bone defects, with the combination of hydrogels and bone graft granules emerging as a trend. Research shows that dextrin-based hydrogels can improve the handling properties of bone substitutes without affecting their osteoconductive features or the bone regeneration process.
REGENERATIVE BIOMATERIALS
(2021)
Review
Engineering, Biomedical
Duoyi Zhao, Tongtong Zhu, Jie Li, Liguo Cui, Zhiyu Zhang, Xiuli Zhuang, Jianxun Ding
Summary: This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Orthopedics
Alina Ruehlemann, Constantin Mayer, Thomas Albrecht, Marcus Jaeger
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2020)
Article
Orthopedics
Andre Busch, Marcus Jaeger, Alexander Wegner, Marcel Haversath, S. Landgraeber, S. Serong, M. Haversath, A. von Wasen, H. Windhagen, T. Floerkemeier, S. Budde, J. Kubilay, Y. Noll, K. S. Delank, J. Baghdadi, R. Willburger, M. Duecker, A. Wilke, F. Huetter
Article
Health Care Sciences & Services
Florian Dittrich, David Alexander Back, Anna Katharina Harren, Marcus Jaeger, Stefan Landgraeber, Felix Reinecke, Sascha Beck
JMIR MHEALTH AND UHEALTH
(2020)
Article
Orthopedics
Andre Busch, Marcus Jaeger, Stefan Klebingat, Josef Baghdadi, Thilo Floerkemeier, Felix Huetter, Thomas M. Grupp, Marcel Haversath
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2020)
Review
Orthopedics
Andre Busch, Alexander Wegner, Marcel Haversath, Marcus Jaeger
Summary: The study discusses the advantages and drawbacks of bone substitutes and their current research status, highlighting limitations of autologous bone grafting and exploring the development of combining ceramic substitutes with osteoinductive substances.
ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
(2021)
Article
Orthopedics
Sascha Beck, Theodor Patsalis, Andre Busch, Florian Dittrich, Alexander Wegner, Stefan Landgraeber, Marcus Jaeger
Summary: The study showed that anatomical stemless press-fit TSA is favorable in terms of implant-related stress shielding. Clinical outcomes were not affected by radiographic changes, demonstrating an 8-year clinical performance comparable to conventional stemmed TSA.
ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
(2021)
Article
Orthopedics
Marcel Haversath, Martin Lichetzki, Sebastian Serong, Andre Busch, Stefan Landgraeber, Marcus Jaeger, Tjark Tassemeier
Summary: In this study, the alignment of a collarless straight tapered HA-coated stem was retrospectively analyzed during the learning phase of the direct anterior approach (DAA) for primary total hip arthroplasty (THA). The results showed that in the learning curve, DAA can be associated with a high incidence of varus stem alignment, especially in men with coxa vara deformity: low CCD, high femoral offset, and long thigh neck.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Article
Sport Sciences
Martin Husen, Lars Burgsmueller, Manuel Burggraf, Marcus Jaeger, Marcel Dudda, Max Kauther
Summary: Rink Hockey is a high-risk sport where players wear little protective gear, head injuries are the most common and caused mostly by ball contact and player contact, it is recommended to use protective gear.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Article
Biology
Nadia Feddahi, Monika Herten, Tjark Tassemeier, Heike Rekasi, Alexander Hackel, Marcel Haversath, Marcus Jaeger
Summary: The study compared the yield and regenerative potency of MSCs in bone marrow aspirate collected using two different needle systems and found that both systems were similar in their ability to produce around 40,000 MSCs per 10 mL, which can be used to enhance bone healing.
Article
Orthopedics
Sebastian Serong, Moritz Schutzbach, Stefan Fickert, Philipp Niemeyer, Christian Sobau, Gunther Spahn, Wolfgang Zinser, Stefan Landgraeber
Summary: This study analyzed patient- and joint-related baseline data of a large cohort of patients with cam-derived femoroacetabular impingement syndrome using the German Cartilage Registry. Factors such as age, sex, body mass index (BMI), and previous hip surgery confirmation were identified to significantly affect preoperative iHOT-33 scores.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2021)
Article
Biology
Roman M. Mueller-Heck, Bjoern Boesken, Ivo Michiels, Marcel Dudda, Marcus Jaeger, Stefanie B. Flohe
Summary: This study investigated the impact of invasive spine surgery on the relationship between monocytes and NK cells in response to Staphylococcus aureus. The findings showed that NK cells continuously lost their ability to produce IFN-gamma during the first week after surgery independently from monocyte-derived IL-12 secretion. Additionally, pre-operative levels of GDF-15 in the serum were associated with the extent of NK cell suppression and hospitalization.
Article
Medicine, General & Internal
Sebastian Serong, Stefan Fickert, Philipp Niemeyer, Ingo J. Banke, Jens Goronzy, Christian Sobau, Wolfgang Zinser, Stefan Landgraeber
Summary: This study reports on a multicenter database of patients undergoing hip arthroscopy for FAI and concomitant cartilage damage. The study identifies male sex, lower BMI, and younger age as parameters associated with better treatment outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Marcus Jaeger, Agnieszka Latosinska, Monika Herten, Andre Busch, Thomas Grupp, Andrea Sowislok
Summary: This study investigates the composition of the initial protein layer on endoprosthetic surfaces and finds that proteins relevant for osseointegration are already adsorbed within 2 minutes. These findings are important for optimizing implant surfaces in orthopedic and trauma surgery.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Medicine, Research & Experimental
Charlotte Bielefeld, Harald Engler, Marcus Jaeger, Alexander Wegner, Dennis Wassenaar, Andre Busch
Summary: The study evaluated the use of the AD-1 test in predicting successful infection eradication in patients undergoing two-stage revision arthroplasty for PJI, but further research is needed to identify more suitable biomarkers for indicating persistent infection before reimplantation.