Article
Biochemistry & Molecular Biology
Stephanie M. Mutchler, Mahpara Hasan, Donald E. Kohan, Thomas R. Kleyman, Roderick J. Tan
Summary: Our study demonstrates that deletion of the gamma subunit of ENaC, while allowing for greater activation of eNOS, is not sufficient to prevent IRI. This suggests that the protective effects of alpha subunit deletion may be due, in part, to other mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Ying Yang, Yang Zhang, Jiqin Yang, Manman Zhang, Tao Tian, Yuan Jiang, Xuening Liu, Genlong Xue, Xingda Li, Xiaofang Zhang, Shangxuan Li, Xiang Huang, Zheng Li, Yang Guo, Lexin Zhao, Hairong Bao, Zhiwen Zhou, Jiahui Song, Guohui Yang, Lina Xuan, Hongli Shan, Zhiren Zhang, Yanjie Lu, Baofeng Yang, Zhenwei Pan
Summary: This study found that ASPP1 protein exacerbates cardiac ischemia/reperfusion (I/R) injury by binding to p53 protein and co-translocating to the nucleus through importin-beta 1. The findings imply that interfering the expression of ASPP1 or the interaction between ASPP1 and p53 to block their nuclear trafficking represents an important therapeutic strategy for cardiac I/R injury.
CIRCULATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Wenbin Luo, Yu Tao, Shengnan Chen, Hao Luo, Xiaoping Li, Shuang Qu, Ken Chen, Chunyu Zeng
Summary: This study found that rosmarinic acid (RA) can effectively protect against pulmonary ischemia/reperfusion (IR) injury by activating the PI3K/Akt signaling pathway for antioxidation and anti-apoptosis, suggesting its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carlos Andres Pantanali, Vinicius Rocha-Santos, Marcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D'Albuquerque, Flavio Henrique Galvao
Summary: Nutraceuticals are bioactive compounds found in food that can improve health, prevent diseases, and support the normal functioning of the human body. They are able to target multiple pathways, acting as antioxidants, anti-inflammatory agents, and immune response and cell death modulators. This study investigated the effect of a nutraceutical solution on liver ischemia-reperfusion injury (IRI), and found that it decreased apoptosis and histologic injury in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Hongji Zhang, Tianmeng Chen, Jinghua Ren, Yujia Xia, Amblessed Onuma, Yu Wang, Jiayi He, Junru Wu, Han Wang, Ahmad Hamad, Chengli Shen, Jinxiang Zhang, John M. Asara, Gregory K. Behbehani, Haitao Wen, Meihong Deng, Allan Tsung, Hai Huang
Summary: The research demonstrates that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype through itaconate metabolism.
Article
Immunology
Qing Yang, Zhen-zhen Zhao, Jian Xie, Yun-peng Wang, Kai Yang, Yu Guo, Jia-feng Wang, Xiao-ming Deng
Summary: The study found that the optimal dose of SEI in treating liver I/R injury was 200 mg/kg. SEI administration reduced ALT, AST, and histopathological injury in I/R liver, similar to GSH. SEI treatment decreased TNF-alpha, IL-113, and IL-6 in liver I/R mice, and inhibited phosphorylation of p65 NF-Kappa B and MAPK kinases in liver tissues. SEI also showed antioxidative, anti-inflammatory, and anti-apoptotic effects in both in vivo and in vitro experiments.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Review
Biochemistry & Molecular Biology
Huijie Zhao, Yihan Yang, Xinya Si, Huiyang Liu, Honggang Wang
Summary: This article reviews the roles of pyroptosis and autophagy in ischemia-reperfusion injury and analyzes the related mechanisms, providing the basis for future research.
Review
Biochemistry & Molecular Biology
Sen Zhang, Sijing Rao, Meiwen Yang, Chen Ma, Fengfang Hong, Shulong Yang
Summary: Hepatic ischemia-reperfusion injury is a major cause of post-operative hepatic dysfunction and liver failure after transplantation. Mitochondrial pathways play a crucial role in hepatic cell apoptosis, depending on multiple factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Chi-Lin Liao, Yang Liu, Meng-Zhao Huang, Hua-Yong Liu, Zi-Liang Ye, Qiang Su
Summary: The study found that curcumin-hydrogel can reduce cardiomyocyte apoptosis, reactive oxygen species formation, promote autophagy, reduce mitochondrial damage, restore cardiac function, inhibit myocardial collagen deposition and apoptosis, and activate the JAK2/STAT3 pathway to alleviate myocardial ischemia-reperfusion injury in rats.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Nan Li, Hong Liu, Yujia Xue, Qiang Zhu, Zhiwen Fan
Summary: This study reveals the crucial role of BRG1 in hepatic ischemia-reperfusion injury (IRI) and suggests that targeting BRG1 with small-molecule inhibitors can be considered as a reasonable therapeutic strategy.
Article
Biotechnology & Applied Microbiology
Xiaoli Min, Linping Zhao, Ying Shi, Jian Wang, Hongling Lv, Xiaoxiao Song, Qunyuan Zhao, Qing Zhao, Rui Jing, Jiayi Hu
Summary: This study investigates the role of Gomisin J in cerebral ischemia-reperfusion injury and finds that it has anti-apoptotic, antioxidant, and anti-inflammatory effects, reducing the severity of the injury.
Review
Biochemistry & Molecular Biology
Hyang-Mi Lee, Ji Woong Choi, Min Sik Choi
Summary: Ischemia-reperfusion injury (IRI) is a damage process induced in hypoxic tissue when oxygen is supplied after ischemia. Restoration of reduced nitric oxide (NO) levels may alleviate reperfusion injury in ischemic organs, with the protective mechanism due to anti-inflammatory and antioxidant effects of NO, as well as regulation of cell signaling pathways. S-nitrosylation (SNO) mediates the detrimental or protective effect of NO depending on the nitrosylated target protein, which also plays a role in the IRI process.
Article
Biochemistry & Molecular Biology
Zhishuang Gao, Chao Li, Haoyu Sun, Yibo Bian, Zhiwei Cui, Nuofan Wang, Zhangjie Wang, Yang Yang, Zonghang Liu, Zhongyuan He, Bowen Li, Fengyuan Li, Zheng Li, Linjun Wang, Diancai Zhang, Li Yang, Zekuan Xu, Xueming Li, Hao Xu
Summary: The study identified USP13 as an essential deubiquitinase that stabilizes ATG5 and promotes autophagy and IM resistance in GIST cells. PAK1 kinase was found to be involved in this process, enhancing the interaction between ATG5 and USP13. The researchers also discovered that N-6-methyladenosine methyltransferase-like 3 (METTL3) mediated the stabilization of USP13 mRNA through IGF2BP2, and an inhibitor of USP13 was shown to enhance the efficacy of IM treatment in GIST cell-derived xenograft models.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Chemistry, Physical
Shuchang Luo, Liyan Zhang, Xudong Zhai, Xiaohui Yang, Xiaoyuan Sun
Summary: The magneto-structural relationship of a dinickel(II) complex with phenoxido/azido coligands was studied using the DFT-BS method. The calculated magnetic coupling constant agreed well with the experimental result. Spin population analyses showed a spin delocalization mechanism in the interactions of the paramagnetic center Ni(II). The nature of the magnetic coupling between Ni(II) ions changed from ferromagnetic to antiferromagnetic with increasing distance between the ions.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Mathematics, Applied
Wei Wang, Mengchen Zhou, Tonghua Zhang, Zhaosheng Feng
Summary: This study investigates the effects of spatial structure, seasonality, and temperature sensitivity of incubation period on the transmission of Zika virus using a PDE model with periodic delay. The simulations show that R0 can be overestimated in the periodic system, underestimated in the absence of seasonality, and reducing the incubation period may reduce the risk of disease transmission.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2023)
Article
Pharmacology & Pharmacy
Tingting Cai, Liqi Shi, Huihui Guo, Ruixing Li, Weiqun Cao, Liang Shen, Mingshe Zhu, Yi Tao
Summary: A generic LC-HRMS method was developed to detect and identify payload-containing catabolites (PCCs) of noncleavable antibody-drug conjugates (ADCs) in vitro. This method provided comprehensive profiling of PCCs and facilitated drug design and preclinical evaluation.
DRUG METABOLISM AND DISPOSITION
(2023)
Review
Obstetrics & Gynecology
Juntao Yin, Yang Li, Yangyang Chen, Chaoyang Wang, Xiaoyong Song
Summary: This study compared the combined use of intracervical Foley catheter and intravaginal misoprostol with the use of intravaginal misoprostol alone for cervical ripening. Thirteen randomized controlled trials involving 2978 participants met the inclusion criteria. The combination group showed no difference in the incidence of cesarean delivery, but had comparable time to delivery, shorter time to vaginal delivery, lower risk of neonatal intensive care unit (NICU) admission, lower risk of meconium-stained fluid, and lower risk of tachysystole with fetal heart trace changes compared to the intravaginal misoprostol-only group.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Water Resources
Hanbing Xu, Songbai Song, Jun Li, Tianli Guo
Summary: The highly non-linear and nonstationary nature of runoff events in changing environments makes accurate and reliable runoff forecasting difficult. In this study, a hybrid model was proposed by integrating various methods, including Bayesian inference and support vector regression, to improve the prediction accuracy. Credible intervals were used to analyze the uncertainty of the parameters and prediction results.
HYDROLOGICAL SCIENCES JOURNAL
(2023)
Article
Plant Sciences
Ting Ren, Furao Liu, Dongxue Wang, Bo Li, Peng Jiang, Junming Li, Hui Li, Changbao Chen, Wei Wu, Lili Jiao
Summary: This study found that GPS-1 from steamed ginseng can regulate lipid metabolism in T2DM rats by modulating gut microbiota and activating the AMP-activated protein kinase pathway, thereby alleviating symptoms such as polyphagia, polydipsia, weight loss, hyperglycemia, hyperlipidemia, and hepatic lipid accumulation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Letter
Virology
Deyan Luo, Tao Li, Xiaolan Yang, Nianzhi Ning, Liangyan Zhang, Hongjing Gu, Deyu Li, Wenjing Yu, Zhongyu Hu, Hui Wang
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Instruments & Instrumentation
Weiqiang Zhao, Jinyun Yan, Hui Liu, Ying Su, Yandong Lin
Summary: LED is now the dominant light source in global lighting market, however, traditional photometry may not be suitable for accurate measurement due to spectral mismatch error. To reduce the measurement uncertainty, LED standard lamp is proposed. This article demonstrates a new type of LED filament lamp for luminous intensity calibration.
Article
Plant Sciences
Yi-Qiang Zhang, Yan Liu, Bo Wen, Si-Yi Wang, Peng Jiang, Jia-Tong Wu, Juan Pan, Wei Guan, Hai-Xue Kuang, Bing-You Yang
Summary: Five schinortriterpenoids and seven lignans were isolated from the leaves of Schisandra chinensis. Among them, a new schinortriterpenoid and a new lignan were discovered. Their structures were determined through spectroscopic analysis. The cytotoxic activities of these compounds were evaluated, and compound 4 exhibited significant activity.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yujie Liu, Muhammad Tayyab, Wenkai Pei, Liang Zhou, Juying Lei, Lingzhi Wang, Yongdi Liu, Jinlong Zhang
Summary: Traditional defect engineering and doping strategies are commonly used to enhance H-2 evolution, but their uncontrollability may not always result in efficient activity. This study presents a defect-induced heteroatom refilling strategy to synthesize carbon nitrides with controlled heteroatom introduction on efficient N1 sites. The refilling of B, P, and S sites shows stronger H2O adsorption and dissociation capacity compared to traditional doping, making it an optimal pathway for H-2 production. The heteroatom-refilled catalysts exhibit a high internal electric field strength, enabling fast electron transfer and achieving a hydrogen production rate of up to 20.9 mmol g(-1) h(-1). This work provides insights into controlled defect engineering of photocatalysts and offers a universal modification strategy for heteroatoms and co-catalyst systems in H-2 production.
Article
Engineering, Civil
Sneha Jha, Yaguang Zhang, Bongsuk Park, Seonghwan Cho, James V. Krogmeier, Tandra Bagchi, John E. Haddock
Summary: This study explores estimating the appropriate pavement patching strategy by integrating pavement structural and surface condition assessment with pavement ratings of distress. A threshold-based patching suggestion algorithm is designed and a web-based Patching Management Tool is developed to visualize the patching suggestion maps and analyze pavement distress data.
TRANSPORTATION RESEARCH RECORD
(2023)
Article
Food Science & Technology
Yujie Liu, Shuo Zhang, Li Tang, Ming Zhang, Pengjiao Wang, Xiaodong Sun, Leyuan Shang, Qi Wang, Yanni Zhao, Duo Meng, Peng Luo, Xiuli Gao
Summary: Various plant polyphenols, including Rosa roxburghii Tratt fruit polyphenols (RRTP), have been found to improve the immune system. Our study revealed that RRTP can regulate the immune functions and balance of lymphocyte subsets in mice. Metabolism studies showed that RRTP can alter various metabolites, mainly involving amino acid, carbohydrate, and lipid metabolism. Furthermore, RRTP has a positive effect on gut microbiota and leads to an increase in short-chain fatty acids (SCFAs), which play a key role in the immunomodulatory effects of RRTP.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biotechnology & Applied Microbiology
Yun Liao, Qinfang Jiang, Xinqian Huo, Li Yu, Jinling Yang, Heng Zhao, Dandan Li, Xingli Xu, Guorun Jiang, Caixing Zhang, Cong Li, Yun Li, Ying Zhang, Mingxiang Shao, Baofeng Liu, Lianzhong Shen, Shengtao Fan, Qihan Li
Summary: Hand, foot and mouth disease is a common acute viral infectious disease that poses a serious threat to the life and health of young children. A bivalent inactivated vaccine against EV71-CA16 has shown good immunogenicity and safety in mice, providing a sufficient basis for further clinical trials.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Yonghui Sun, Linnan Jiang, Lijuan Liu, Yong Chen, Wen-Wen Xu, Jie Niu, Yuexiu Qin, Xiufang Xu, Yu Liu
Summary: Two kinds of amorphous solid-state supramolecular systems with purely organic room temperature phosphorescence (RTP) were reported, which were activated by calix[3]phenothiazine (C[3]Pz) and 1,2-/1,3-dicyanobenzene (1,2-/1,3-DCB). The RTP of these supramolecular systems was entirely from the interaction between 1,2-/1,3-DCB and C[3]Pz, forming dense supramolecular complexes, leading to two different phosphorescence emissions. The use of 1,2-DCB and 1,3-DCB as molecular rivets fixed the C[3]Pz, inhibiting molecular vibration and reducing nonradiative relaxation, resulting in effective RTP emission with high quantum yields.
ADVANCED OPTICAL MATERIALS
(2023)