Article
Agriculture, Dairy & Animal Science
Madalina Elena Henea, Eusebiu Viorel Sindilar, Liviu Catalin Burtan, Iuliana Mihai, Mariana Grecu, Alina Anton, Gheorghe Solcan
Summary: Spinal cord injuries in dogs are common and often caused by trauma or discal hernia. Physiotherapy and assisted gait devices can help paralyzed dogs develop spinal walking and improve their quality of life.
Article
Medicine, General & Internal
Xiangcheng Gao, Yining Gong, Bo Zhang, Dingjun Hao, Baorong He, Liang Yan
Summary: This study analyzed the factors affecting the instant recovery of neurological function in patients with motor complete traumatic spinal cord injury (TSCI) treated in hospital. The results showed that the ASIA score on admission, fracture or dislocation, treatment protocol, and inpatient rehabilitation were independently associated with the recovery of neurological function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Taoyang Yuan, Yu Shao, Xu Zhou, Qian Liu, Zhichao Zhu, Bini Zhou, Yuanchen Dong, Nicholas Stephanopoulos, Songbai Gui, Hao Yan, Dongsheng Liu
Summary: Researchers have developed a DNA hydrogel to repair spinal cord gap in rats, promoting proliferation and differentiation of stem cells for functional recovery. This hydrogel system shows great potential in clinical trials and could be adaptable to other tissue regeneration applications.
ADVANCED MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Deqing Peng, Min Yan, Tianjian Liu, Kaichuang Yang, Yuyuan Ma, Xinben Hu, Guangyu Ying, Yongjian Zhu
Summary: This retrospective study analyzed 105 patients admitted for spontaneous spinal epidural hematoma (SSEH) and found that lower thoracic spine location, anticoagulation usage, severe neurologic deficits, sphincter dysfunction, and rapid progression may be associated with poor outcomes. In the subset of patients who underwent surgical decompression, preoperative neurologic deficit and extended paraplegia time were strongly correlated with prognosis.
Review
Neurosciences
Soshi Samejima, Richard Henderson, Jared Pradarelli, Sarah E. Mondello, Chet T. Moritz
Summary: Spinal cord injuries often result in permanent physical impairments despite being incomplete disruptions. However, remaining connections between the brain and spinal cord can induce neural plasticity to improve sensorimotor function, even years post-injury. This review provides an overview of evidence for motor recovery, plasticity, and interventions in spinal cord stimulation for motor control restoration. It discusses both open-loop and closed-loop stimulation approaches, as well as mechanisms of spinal cord neuromodulation for sensorimotor recovery, aiming to advance rehabilitation for spinal cord injuries.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Orthopedics
Soshi Samejima, Charlotte D. Caskey, Fatma Inanici, Siddhi R. Shrivastav, Lorie N. Brighton, Jared Pradarelli, Vincente Martinez, Katherine M. Steele, Rajiv Saigal, Chet T. Moritz
Summary: This study aimed to investigate the effects of transcutaneous spinal cord stimulation combined with intensive training in individuals with chronic spinal cord injury. The results showed that this intervention significantly improved walking ability, balance, sensation, and bowel function in the participants. It suggests that noninvasive spinal cord stimulation could promote recovery of locomotor and autonomic functions in people with chronic incomplete cervical SCI.
Article
Biotechnology & Applied Microbiology
Sisi Mi, Xue Wang, Jiaxin Gao, Yu Liu, Zhongquan Qi
Summary: After spinal cord injury (SCI), the microenvironment inhibits neural regeneration due to the abundance of inhibitory factors and lack of factors promoting nerve regeneration. This study developed a bioactive material, hp-SHED sheet, to mimic the natural spinal cord structure and enhance nerve cell attachment and migration. Implantation of hp-SHED sheet in SCI rats promoted nerve regeneration, axonal remyelination, and inhibited glial scarring, leading to the restoration of sensory and motor functions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Gaetan Poulen, Emilie Aloy, Claire M. Bringuier, Nadine Mestre-Frances, Emaelle V. F. Artus, Maida Cardoso, Jean-Christophe Perez, Christophe Goze-Bac, Hassan Boukhaddaoui, Nicolas Lonjon, Yannick N. Gerber, Florence E. Perrin
Summary: By using the CSF1R inhibitor GW2580, transient reduction of microglia proliferation can improve motor function recovery in SCI patients. The treatment also helps reduce neuroinflammation and enhance tissue protection.
Article
Neurosciences
Wu Jiang, Fan He, Guoming Ding, Junsong Wu
Summary: This study aimed to investigate the protective effect of the novel mitochondria-targeted peptide EPT in spinal cord injury (SCI). The results showed that EPT improved locomotor functional recovery and reduced neuronal loss. EPT also inhibited NLRP3 inflammasome activation and elevated levels of pro-inflammatory cytokines. Furthermore, EPT alleviated mitochondrial dysfunction and reduced mitochondrial reactive oxygen species level. Therefore, EPT may protect against SCI by inhibiting pyroptosis.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Kristina Loy, Julie Fourneau, Ning Meng, Carmen Denecke, Giuseppe Locatelli, Florence M. Bareyre
Summary: In this study, the researchers identified Semaphorin7A (Sema7A) as a critical regulator of serotonergic circuit formation in the injured spinal cord, with Sema7A deficiency leading to an increase in serotonergic fiber density. While these alterations seem to be compensated in adult mice, spinal lesion challenge revealed changes in serotonergic innervation patterns, correlating with diminished functional recovery.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wu Jiang, Fan He, Guoming Ding, Junsong Wu
Summary: This study investigated the effects of Top1 inhibition in a spinal cord injury (SCI) model. The results showed that administration of the Top1 inhibitor CPT improved locomotor functional recovery, reduced neuronal loss, and decreased neutrophil infiltration in mice with SCI. Additionally, CPT inhibited pyroptosis and suppressed neuroinflammation both in vivo and in vitro.
Article
Pharmacology & Pharmacy
Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini Ravandi, Mahmoudreza Hadjighassem
Summary: This study found that early administration of bumetanide after spinal cord injury can promote recovery of locomotor function. The results showed that bumetanide can reduce the expression of NKCC1 gene and increase GAP protein levels, thereby having neuroprotective and regenerative effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Samineh Mesbah, Tyler Ball, Claudia Angeli, Enrico Rejc, Nicholas Dietz, Beatrice Ugiliweneza, Susan Harkema, Maxwell Boakye
Summary: The study found that in individuals with clinically motor complete spinal cord injury, the extent of recovery of lower limb voluntary movements with scES is significantly influenced by the percentage of lumbosacral enlargement coverage by the electrode array and the position of the electrode relative to the lumbosacral enlargement and conus tip.
Article
Clinical Neurology
Samineh Mesbah, Tyler Ball, Claudia Angeli, Enrico Rejc, Nicholas Dietz, Beatrice Ugiliweneza, Susan Harkema, Maxwell Boakye
Summary: The study showed that in individuals with chronic spinal cord injury, there was a significant correlation between the coverage rate of lumbosacral enlargement by the electrode array and the position of the electrode, and the number of joints moved during voluntary lower limb movements. However, there was no significant correlation between the cross-section area of the spinal cord at C3 or the length of severe myelomalacia and the ability to move the lower limbs voluntarily.
Article
Clinical Neurology
Giulia Blasetti, Chiara Pavese, Doris D. Maier, Norbert Weidner, Ruediger Rupp, Rainer Abel, B. Kalke Yorck, Kriz Jiri, Armin Curt, Marco Molinari, Martin Schubert, Giorgio Scivoletto
Article
Clinical Neurology
Giorgio Scivoletto, Masciullo Marcella, Pichiorri Floriana, Tamburella Federica, Molinari Marco
Article
Clinical Neurology
Alessio Conti, Fulvio Ricceri, Giorgio Scivoletto, Marco Clari, Sara Campagna
Summary: This cross-sectional study in Italy aimed to identify predictors of quality of life among family caregivers of people with spinal cord injuries. The study found that caregiver burden significantly predicted reduced quality of life among family caregivers, with contextual factors such as economic difficulties and the presence of a formal caregiver also playing a role. The study highlights the importance of minimizing caregiver burden to promote caregiver well-being.
Article
Clinical Neurology
Emanuela Lena, Ilaria Baroncini, Chiara Pavese, Gaia Musumeci, Silvia Volini, Marcella Masciullo, Beatrice Aiachini, Gabriella Fizzotti, Mariangela V. Puci, Giorgio Scivoletto
Summary: The study aimed to evaluate the measurement properties of ISNCSCI in patients with non-traumatic SCI. Results showed that ISNCSCI demonstrated good internal consistency, rating agreement, and high correlation with SCIM scores.
Article
Clinical Neurology
Alessio Conti, Sara Campagna, Maeve Nolan, Giorgio Scivoletto, Barbara Bandini, Alberto Borraccino, Ercole Vellone, Valerio Dimonte, Marco Clari
Summary: The study developed two instruments, SC-SCII and SCSES-SCI, to assess self-care in patients with spinal cord injury, with satisfactory reliability and validity.
Review
Engineering, Biomedical
Federica Tamburella, Matteo Lorusso, Marco Tramontano, Silvia Fadlun, Marcella Masciullo, Giorgio Scivoletto
Summary: Overground powered lower limb exoskeletons have proven to be effective in gait rehabilitation for individuals with spinal cord injury. This systematic review provides a general overview of the effects of commercial exoskeletons for medical purposes in individuals with SCI. However, due to the limitations in study quality and heterogeneity in outcome measures, protocols, and SCI features, it is not possible to draw general conclusions about the effects of exoskeleton usage.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Clinical Neurology
Lisa A. Harvey, Joanne V. Glinsky, Jackie Chu, Robert D. Herbert, Hueiming Liu, Stephen Jan, Laurent Billot, Giorgio Scivoletto, Annemie I. Spooren, Henk A. Seelen, Marsha Ben, Keira Tranter, Lydia W. Chen, Donna Rainey, Christine Rimmer, Vivien Jorgensen, Fernanda Di Natal, Sophie Denis, Emilie J. Gollan, Federica Tamburella, Jacqui Agostinello, Charlotte M. van Laake-Geelen, Chris Bell, Claire Lincoln, Janneke M. Stolwijk, Jessica van der Lede, Sue Paddison, Kristine Oostra, Ian D. Cameron, Gerard Weber, Catherine Sherrington, Andrew K. Nunn, Emma-Leigh Synnott, Euan McCaughey, Jasbeer Kaur, Sachin Shetty
Summary: This study is a multi-centre randomised controlled trial aiming to determine whether intensive motor training for 10 weeks enhances neurological recovery in individuals with recent spinal cord injury (SCI). The trial will take place in 15 spinal injury units across Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium. Two hundred and twenty participants with recent SCI will be randomised to receive either usual care plus intensive motor training or usual care alone, with various outcomes measured at 10 weeks and 6 months.
Article
Clinical Neurology
Adrian Cathomen, Doris Maier, Jiri Kriz, Rainer Abel, Frank Roehrich, Michael Baumberger, Giorgio Scivoletto, Norbert Weidner, Ruediger Rupp, Catherine R. Jutzeler, John D. Steeves, Armin Curt, Marc Bolliger
Summary: This study developed a prediction-based stratification model to determine walking function and its underlying muscle functions in individuals with paraplegic spinal cord injury (SCI). The results revealed that the muscle function closer to the spinal cord injury played a crucial role in predicting walking function. When assessing the prognosis of walking function, it is important to consider the individual differences in muscle function.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Clinical Neurology
Kristin Gustafson, Michael Stillman, Maclain Capron, Colleen O'Connell, Melina Longoni Di Giusto, Nishu Tyagi, Giorgio Scivoletto
Summary: The COVID-19 pandemic has had a negative impact on individuals with spinal cord injury/disease, limiting their access to usual level of care, worsening medical complications, and leading to restricted access to clinician and support services. Despite an increase in the use of telemedicine, over 60% of respondents felt that the technology incompletely met their patients' needs.
SPINAL CORD SERIES AND CASES
(2021)
Article
Medicine, General & Internal
M. Masciullo, F. Pichiorri, G. Scivoletto, C. Foti, M. Molinari
Summary: This case report emphasizes the importance of individual response to certain pharmacological agents and suggests the need for further studies on the pharmacodynamics of flumazenil and gabapentin to better understand their molecular-receptor activity. It also highlights the potential multiple mechanisms of action of flumazenil, beyond its classical benzodiazepine antagonist action.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Article
Clinical Neurology
Chiara Pavese, Giorgio Scivoletto, Mariangela Puci, Martin Schubert, Armin Curt, Enrico Finazzi Agro, Cristina Montomoli, Thomas M. Kessler
Summary: This study aimed to validate prediction models for bowel outcomes after traumatic spinal cord injury (SCI). Through validation with an independent sample, the study demonstrated the validity of a simple model in predicting independent and reliable bowel management 1 year after SCI.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Engineering, Biomedical
C. Meijneke, G. van Oort, V Sluiter, E. van Asseldonk, N. L. Tagliamonte, F. Tamburella, I Pisotta, M. Masciullo, M. Arquilla, M. Molinari, A. R. Wu, F. Dzeladini, A. J. Ijspeert, H. van der Kooij
Summary: The Symbitron exoskeleton is a lower limb modular exoskeleton designed for individuals with spinal cord injuries, featuring personalized mechanical and electrical configuration and control. Research findings indicate that this exoskeleton helps SCI individuals regain mobility and provides tailored support based on their specific needs and conditions.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Clinical Neurology
Giorgio Scivoletto, Marcella Masciullo, Floriana Pichiorri, Marco Molinari
SPINAL CORD SERIES AND CASES
(2020)
