Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychology, Educational
David A. A. Gast, Gabriela L. C. de Wit, Amber van Hoof, Jeanne H. M. de Vries, Bert van Hemert, Robert Didden, Erik J. Giltay
Summary: The study revealed lower diet quality among people with intellectual disabilities, with those with mild and borderline intellectual functioning having lower diet quality compared to those with severe to profound intellectual disabilities. Being female was identified as a predictor of better diet quality.
JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
(2022)
Article
Psychology, Multidisciplinary
Laura J. Mattie, Susan J. Loveall, Marie Moore Channell, Derek B. Rodgers
Summary: The purpose of this article was to explore the utility of including measures of both intellectual and adaptive functioning in research on intellectual disability (ID). The data showed that while there was some consistency between intellectual and adaptive functioning in some children, there were differences in others. Therefore, using both measures when describing samples with ID can provide benefits.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Genetics & Heredity
Shota Nishitani, Ryoko Kasaba, Daiki Hiraoka, Koji Shimada, Takashi X. Fujisawa, Hidehiko Okazawa, Akemi Tomoda
Summary: The study suggests that increasing reproductive efforts are associated with decelerated aging in mothers with one to four children, mediated by structural changes in the precuneus.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Cindy H. Lee, Kristi L. Bartholomay, Matthew J. Marzelli, Jonas G. Miller, Jennifer L. Bruno, Amy A. Lightbody, Allan L. Reiss
Summary: This study investigated neuroanatomical differences in young females with fragile X syndrome compared to a matched control group. The results showed larger total gray and white matter volumes in girls with fragile X syndrome, as well as differences in specific brain regions. These findings provide insights into the gene-brain-behavior relationships underlying the fragile X syndrome phenotype in females and expand our understanding of the neurodevelopmental mechanisms in this condition.
Article
Clinical Neurology
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Goeerss, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Duezel, Gabriel Ziegler
Summary: This study used voxel-based morphometry to validate the classification system of Alzheimer's disease biomarkers. The results showed that early amyloid conversion is associated with brain volume loss, supporting the monotonic progression model of the amyloid-tau-neurodegeneration (ATN) system.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Claudia Piervincenzi, Martina Fanella, Nikolaos Petsas, Marianna Frascarelli, Alessandra Morano, Tommaso Accinni, Fabio Di Fabio, Carlo Di Bonaventura, Alfredo Berardelli, Patrizia Pantano
Summary: This study found specific grey matter volume (GMV) reductions in the cerebellum (lobes VIII and Crus II) and the left superior occipital gyrus in patients with 22q11.2 deletion syndrome (22q11.2DS) and parkinsonism. Although bothPark+ and Park- patients showed GMV decrements in these regions, the reductions were greater in Park+ patients. However, GMV loss did not correlate with clinical scores.
Article
Anatomy & Morphology
Stephanie Seidenbecher, Maria Schoene, Joern Kaufmann, Kolja Schiltz, Bernhard Bogerts, Thomas Frodl
Summary: The present study examined the structural brain characteristics in two healthy samples differing only in their propensity for aggressive behavior, revealing brain structural differences between the two groups in frontal and parietal brain areas critical for emotion processing/inhibition and empathy processes.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Behavioral Sciences
William D. S. Killgore, John R. Vanuk, Natalie S. Dailey
Summary: The study compared the effects of blue-light exposure treatment and amber light treatment on sleep in individuals with PTSD, finding that BLT increased total time in bed and total sleep time, while ALT improved wake after sleep onset and sleep efficiency, possibly correlated with increased amygdala volume.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Pediatrics
Heli Satila, Laura Mirjami Jolma, Mira Merilainen-Nipuli, Mikko Koivu-Jolma
Summary: This retrospective chart review study aimed to explore the neuropsychological profiles, comorbidity of neuropsychiatric and psychiatric disorders, changes in diagnoses, support at daycare and school, medication use, psychiatric referrals, and progress into further education of participants with borderline intellectual functioning (BIF). The study found that delays in language and gross motor development were the initial concerns of parents seeking healthcare. Comorbid neuropsychiatric and psychiatric diagnoses were common, with a significant number of participants requiring psychiatric services and medication. The majority of participants needed educational support, and the risk of dropping out during secondary studies was found to increase. The results also showed a decline in most neuropsychological subdomains over time, and a portion of the participants later received a diagnosis of intellectual disability (ID). Early developmental signs indicating BIF and the need for timely support included delayed language and motor development, difficulties in executive function, delayed learning of daily activities in preschool children, and difficulties in reading, arithmetic, and abstract reasoning in school-age children. It is important to follow up and provide support for individuals with BIF as they are at risk of being left behind in society. Additionally, repeating neuropsychological testing for cognitive and adaptive functions before graduating elementary school to identify those who meet ID criteria would also be valuable.
Article
Neurosciences
Feng-Yi Su, Jyun-Ru Chen, Chun-Ming Chen, Yen-Chih Huang, Shin-Lei Peng
Summary: This study identified patterns of gray matter volume changes with age in a young population, highlighting the influence of field strength on results and the importance of considering this factor when comparing brain differences across studies.
Article
Geriatrics & Gerontology
Enrico Premi, Maria Cotelli, Elena Gobbi, Ilaria Pagnoni, Giuliano Binetti, Yasmine Gadola, Ilenia Libri, Irene Mattioli, Marta Pengo, Armin Iraji, Vince D. Calhoun, Antonella Alberici, Barbara Borroni, Rosa Manenti
Summary: This study investigates the neuroanatomical correlates of language deficits in avPPA using verbal fluency tasks, AAT naming subtest, and SAND scores as proxies of brain structural imaging abnormalities.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Zi-wen Wang, Zi-han Yin, Xiao Wang, Yu-tong Zhang, Tao Xu, Jia-rong Du, Yi Wen, Hua-qiang Liao, Yu Zhao, Fan-rong Liang, Ling Zhao
Summary: This study found that patients with menstrual migraine (MM) exhibit structural and functional alterations in the brain, particularly in the anterior cingulum cortex (ACC), which are associated with the severity of pain and pain-related impairment of emotion. The ACC may be an important biomarker in MM.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Education, Special
Jessica Vervoort-Schel, Gabrielle Mercera, Inge Wissink, Peer Van der Helm, Ramon Lindauer, Xavier Moonen
Summary: The study found a high prevalence of ACEs in children with ID and BIF, with family context risk variables showing an association with the number of ACEs. Awareness of ACEs in clinical practice is crucial to mitigate negative outcomes.
RESEARCH IN DEVELOPMENTAL DISABILITIES
(2021)
Article
Psychology, Educational
Femke Jonker, Robert Didden, Laurette Goedhard, Hubert Korzilius, Henk Nijman
Summary: The ADAPT tool is effective in measuring adaptive skills in individuals with ID, showing high internal consistency and positive correlations with IQ, educational level, and level of independent living. Reference values can be used to estimate the level of ID and needed support intensity.
JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
(2021)
Article
Public, Environmental & Occupational Health
A. Caldiroli, I Tagliabue, M. Turco, E. Capuzzi, A. Fortunato, A. Tringali, C. Montana, L. Maggioni, C. Pellicioli, M. Sibilla, M. Marcatili, G. Crespi, F. Colmegna, M. Buoli, M. Clerici
Summary: The COVID-19 pandemic has had a significant impact on mental health, and this study aimed to compare the difference between psychiatric patients and healthy controls in terms of post-traumatic stress disorder (PTSD) symptoms over time. The study found that the lockdown period was perceived as more traumatic by both groups, psychiatric patients had lower levels of PTSD symptoms compared to the healthy controls, and patients with personality disorders may be more vulnerable to PTSD symptoms.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Alice Caldiroli, Enrico Capuzzi, Ilaria Tagliabue, Luisa Ledda, Massimo Clerici, Massimiliano Buoli
Summary: This review summarizes the efficacy of unlabeled molecules for the treatment of social anxiety disorder (SAD). Pregabalin at high doses appears to be a reliable alternative strategy for SAD treatment. Among the SSRIs not labeled for SAD, citalopram showed the most promising results.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Silvia Picciolini, Domenico Caputo, Marco Rovaris, Maria Barbara Pasanisi, Mario Clerici
Summary: Approximately 15% of MS patients develop primary progressive form of disease, which is difficult to diagnose and treat. Brain-derived EVs and their protein cargoes could potentially serve as biomarkers for MS. The study found that MBP concentration in ODEVs was significantly increased in MS patients and correlated with disease severity. A minimally invasive blood test measuring MBP concentration in ODEVs could be a promising tool for MS diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Federica Rossetto, Sara Isernia, Olivia Realdon, Francesca Borgnis, Valeria Blasi, Chiara Pagliari, Monia Cabinio, Margherita Alberoni, Fabrizia Mantovani, Mario Clerici, Francesca Baglio
Summary: This study evaluated a new model of rehabilitation for people with cognitive disabilities, using asynchronous telerehabilitation. The results showed that the asynchronous telerehabilitation model can meet the needs of a broad population and has positive effects on cognitive and behavioral abilities.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Claudia Vanetti, Vito Lampasona, Marta Stracuzzi, Claudio Fenizia, Mara Biasin, Irma Saulle, Fiona Limanaqi, Ahmed Abdelsalam, Cristian Loretelli, Laura Paradiso, Emma Longoni, Lucia Barcellini, Lorenzo Piemonti, Ilaria Marzinotto, Stefania Dispinseri, Antonella Amendola, Clara Fappani, Elisabetta Tanzi, Mario Salvatore Clerici, Gabriella Scarlatti, Gian Vincenzo Zuccotti, Vania Giacomet, Daria Trabattoni
Summary: This study analyzed the immune profiles of 18 hospitalized children with SARS-CoV-2 infection and found that different severity levels of children cases showed different immune characteristics. Infants with severe symptoms exhibited high inflammatory response and extreme antibody response, while mild cases had lower levels of inflammation and antibodies. Overall, the immune response in children is directly correlated with the clinical severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Francesca La Rosa, Simone Agostini, Federica Piancone, Ivana Marventano, Ambra Hernis, Chiara Fenoglio, Daniela Galimberti, Elio Scarpini, Marina Saresella, Mario Clerici
Summary: Alzheimer's Disease (AD) is the most common form of dementia, characterized by the deposition of neurotoxic plaques composed of amyloid-beta (Ab). Peripheral inflammation has been identified as an early event in AD pathogenesis. This study focuses on TREM2, a receptor that plays a role in immune cell function and may serve as a potential peripheral biomarker for AD diagnosis and prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Allergy
Marta Stracuzzi, Claudia Vanetti, Mario Clerici, Gian Vincenzo Zuccotti, Daria Trabattoni, Vania Giacomet
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hend Alfadul, Shaun Sabico, Mohammed G. A. Ansari, Abdullah M. Alnaami, Osama E. Amer, Syed D. Hussain, Kaiser Wani, Malak N. K. Khattak, Mario Clerici, Nasser M. Al-Daghri
Summary: Inflammasome activation of NLRP3 is involved in the pathogenesis of inflammatory diseases. Limited studies have reported the associations between NLRP3 levels or other circulating interleukins and glycemic status. This study investigated the differences and associations between serum levels of NLRP3 and ILs in Arab adults with prediabetes and type 2 diabetes mellitus.
Article
Health Care Sciences & Services
Alice Caldiroli, Lia Colzani, Enrico Capuzzi, Cecilia Quitadamo, Davide La Tegola, Teresa Surace, Stefania Russo, Mauro Capetti, Silvia Leo, Agnese Tringali, Matteo Marcatili, Francesco Zanelli Quarantini, Fabrizia Colmegna, Antonios Dakanalis, Massimiliano Buoli, Massimo Clerici
Summary: Generalized Anxiety Disorder (GAD) and Panic Disorder (PD) share similar neurobiological mechanisms and clinical features, leading to potential misdiagnosis and delayed treatment. This study aimed to assess the relationship between clinical and socio-demographic markers and GAD/PD diagnosis. Out of 290 outpatients identified with PD or GAD in mental health services in Italy, post-onset psychiatric and medical comorbidities were associated with GAD, while treatment with selective serotonin reuptake inhibitors (SSRIs) was associated with PD. GAD patients had a worse prognosis due to higher comorbidity rates, relapses, and poorer treatment compliance. The association between GAD and psychodynamic psychotherapy was a unique finding of this study.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Ingrid Battistella, Alessandro Cutarelli, Jacopo Zasso, Massimo Clerici, Carlo Sala, Matteo Marcatili, Luciano Conti
Summary: Astrocytes have important functions in coordinating various homeostatic processes in the central nervous system. A new protocol for generating mature astrocytes from hiPSCs has been developed, allowing for the study of astrocyte functions in human cell contexts and patient-specific settings. The optimized monolayer procedure presented in this study enables the efficient differentiation of hiPSC-derived cortical progenitors into mature astrocytes, providing a valuable tool for investigating the role of these cells in neurodevelopmental and neuropsychiatric diseases and for drug development and biomarker discovery/validation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Neurosciences
Giordano Gentile, Mark Jenkinson, Ludovica Griffanti, Ludovico Luchetti, Matteo Leoncini, Maira Inderyas, Marzia Mortilla, Rosa Cortese, Nicola De Stefano, Marco Battaglini
Summary: In this study, a novel tool called BIANCA-MS is presented for brain white matter lesion segmentation in multiple sclerosis (MS). BIANCA-MS is able to generalize across different MRI acquisition protocols and heterogeneity of manually labeled data. It outperformed other available tools in high- and low-resolution images and provided comparable performance across different scanning protocols, sets of modalities, and image resolutions. The findings suggest that BIANCA-MS is a robust and accurate approach for automated MS lesion segmentation.
HUMAN BRAIN MAPPING
(2023)
Article
Biochemistry & Molecular Biology
Elisabetta Bolognesi, Franca Rosa Guerini, Alessandra Carta, Matteo Chiappedi, Stefano Sotgiu, Martina Maria Mensi, Cristina Agliardi, Milena Zanzottera, Mario Clerici
Summary: Autism spectrum disorders (ASD) can have different onset patterns, and the SNAP-25 gene's single nucleotide polymorphisms (SNPs) may serve as diagnostic biomarkers for distinguishing early onset and regressive onset ASD, as well as providing insights into tailored therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sergio Strizzi, Letizia Bernardo, Pasqualina D'Ursi, Chiara Urbinati, Andrea Bianco, Fiona Limanaqi, Andrea Manconi, Maria Milanesi, Alberto Macchi, Dario Di Silvestre, Adalberto Cavalleri, Giovanni Pareschi, Marco Rusnati, Mario Clerici, PierLuigi Mauri, Mara Biasin
Summary: A multidisciplinary approach was used to investigate the effect of UV-C irradiation on the S protein of SARS-CoV-2. The study identified the disruption of a disulphide bond, which resulted in a conformational change and reduced binding ability to the ACE2 receptor. The findings suggest the S2 domain of the S protein as a potential therapeutic target for preventing SARS-CoV-2 infection.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Valentina Camera, Romina Mariano, Silvia Messina, Ricarda Menke, Ludovica Griffanti, Matthew Craner, Maria Leite, Massimiliano Calabrese, Stefano Meletti, Ruth Geraldes, Jacqueline A. Palace
Summary: In this study, fatigue was found to be frequently reported in patients with multiple sclerosis, aquaporin-4-antibody neuromyelitis optica spectrum disorder and myelin-oligodendrocyte-glycoprotein antibody disease, suggesting a common pathophysiological mechanism.
BRAIN COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Alice Caldiroli, Enrico Capuzzi, Letizia M. M. Affaticati, Teresa Surace, Carla L. L. Di Forti, Antonios Dakanalis, Massimo Clerici, Massimiliano Buoli
Summary: Social anxiety disorder (SAD) is a common psychiatric condition that requires prompt treatment to prevent psychiatric comorbidity and impairment in social and occupational functioning. This study systematically reviewed the literature on potential biomarkers for SAD. While some preliminary evidence suggests the role of certain genes and neuroimaging findings in SAD, the results overall remain inconsistent and need further investigation on larger samples to identify more specific biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)