Article
Psychology, Developmental
Heather L. Green, Guannan Shen, Rose E. Franzen, Marybeth Mcnamee, Jeffrey I. Berman, Theresa G. Mowad, Matthew Ku, Luke Bloy, Song Liu, Yu-Han Chen, Megan Airey, Emma McBride, Sophia Goldin, Marissa A. Dipiero, Lisa Blaskey, Emily S. Kuschner, Mina Kim, Kimberly Konka, Timothy P. L. Roberts, J. Christopher Edgar
Summary: This study assessed the maturation of auditory cortex neural encoding processes in children with autism compared to typically developing children. The results showed that children with autism experienced rapid maturation of the auditory cortex earlier than typically developing children, followed by faster maturation in the typically developing group. Additionally, stronger pre-stimulus brain activity was found in children with autism across all time points, indicating its stability over time.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Neurosciences
Marlee M. Vandewouw, Benjamin T. Dunkley, Jason P. Lerch, Evdokia Anagnostou, Margot J. Taylor
Summary: Examining the brain at rest using Inscapes reduces head motion and shows stable effects in clinical populations like autism spectrum disorder and attention-deficit/hyperactivity disorder. Movie paradigms induce changes in local neural activity and functional connectivity in resting-state networks.
Article
Psychiatry
Christina Isakoglou, Koen V. V. Haak, Thomas Wolfers, Dorothea L. L. Floris, Alberto Llera, Marianne Oldehinkel, Natalie J. J. Forde, Bethany F. M. Oakley, Julian Tillmann, Rosemary J. J. Holt, Carolin Moessnang, Eva Loth, Thomas Bourgeron, Simon Baron-Cohen, Tony Charman, Tobias Banaschewski, Declan G. M. Murphy, Jan K. K. Buitelaar, Andre F. F. Marquand, Christian F. F. Beckmann
Summary: Sensory atypicalities are common in autism spectrum disorders (ASD), but the functioning of the somatosensory region and its association with the ASD phenotype is not well understood. In this study, we examined the functional connectivity of the primary somatosensory cortex (S1) in autistic and neurotypical individuals. We found that the S1 connectopy is organized along a dorsoventral axis and is associated with adaptive functioning skills. Furthermore, the S1 connectopy showed differences between rest and emotion processing, indicating a task-modulating effect.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Yuko Yoshimura, Takashi Ikeda, Chiaki Hasegawa, Kyung-Min An, Sanae Tanaka, Ken Yaoi, Sumie Iwasaki, Daisuke N. Saito, Hirokazu Kumazaki, Hirotoshi Hiraishi, Mitsuru Kikuchi
Summary: The study revealed atypical brain maturation in the auditory processing area in children with ASD without intellectual disability, showing significant differences compared to TD children. Additionally, ASD may have a common neural basis for pure-tone sound processing and language development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Rubin Jure
Summary: A better understanding of the pathogenesis of autism can help us understand the complexity of normal brain development. The crucial deficit may lie in the postnatal changes in the brainstem nuclei caused by vision. The superior colliculus plays a key role in behavior and influences basic aspects of our behavior by acting as a brain sentinel. The disruption of collicular and brainstem functions may explain some of the enigmas of autism.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Review
Psychology
Ilina Bhaya-Grossman, Edward F. Chang
Summary: Human speech perception relies on neural computations in the superior temporal gyrus (STG) to transform external acoustic speech signals into internal representations. The STG employs nonlinear and dynamical processes such as categorization, normalization, contextual restoration, and temporal structure extraction to represent speech sounds. The complex auditory encoding for different acoustic-phonetic and prosodic features in the STG suggests that distributed patterns of neural activity give rise to abstract, higher-order phonemic and syllabic representations.
ANNUAL REVIEW OF PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Carly Demopoulos, Sara A. Skiba, Brandon E. Kopald, Nitin Bangera, Kim Paulson, Jeffrey David Lewine
Summary: This study examined the relationship between rapid auditory processing of speech sounds and verbal communication abilities in individuals with autism spectrum disorder (ASD). The results showed that impaired rapid auditory processing was associated with deficits in speech articulation, expressive language abilities, vocabulary, and phonological memory.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Ya-Ting Chang, Max Kowalczyk, P. Michelle Fogerson, Yu-Ju Lee, Minza Haque, Eliza L. Adams, David C. Wang, Laura A. DeNardo, Marc Tessier-Lavigne, John R. Huguenard, Liqun Luo, Wei-Hsiang Huang
Summary: Hyperexcitability of brain circuits is a common feature of autism spectrum disorders. This study identifies Rai1 as a negative regulator of excitability, and its deletion results in increased seizure susceptibility and prolonged hippocampal seizure duration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychiatry
Liliana Dell'Osso, Giulia Amatori, Barbara Carpita, Gabriele Massimetti, Benedetta Nardi, Davide Gravina, Francesca Benedetti, Chiara Bonelli, Danila Casagrande, Mario Luciano, Isabella Berardelli, Natascia Brondino, Marianna De Gregorio, Giacomo Deste, Marta Nola, Antonino Reitano, Maria Rosaria Anna Muscatello, Maurizio Pompili, Pierluigi Politi, Antonio Vita, Mario Maj
Summary: Several studies have found a correlation between autism spectrum disorder (ASD) and catatonia, both of which are also associated with mood disorders. This study aimed to investigate the relationship between autistic traits and catatonic symptoms, as well as the potential mediating role of mood disorder spectrum. The results showed strong positive correlations, with the strongest coefficient observed between AdAS Spectrum total score and CS total score. Mediation analysis revealed that the mood disorder spectrum had a significant indirect effect on the relationship between autistic traits and catatonic symptoms.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Charis Styliadis, Rachel Leung, Selin Ozcan, Eric A. Moulton, Elizabeth Pang, Margot J. Taylor, Christos Papadelis
Summary: The study found that adolescents with ASD showed overactivation in the left hemisphere of the cerebellum when processing happy facial expressions, and overactivation in the midline of the cerebellum when processing angry facial expressions. This indicates a prioritized hemispheric activity for happy faces and a later midline activity for angry faces in adolescents with ASD.
HUMAN BRAIN MAPPING
(2021)
Review
Psychiatry
V Nezgovorova, C. J. Ferretti, B. P. Taylor, E. Shanahan, G. Uzunova, K. Hong, O. Devinsky, E. Hollander
Summary: Current treatments for ASD are limited in efficacy, leading to the need for novel experimental therapeutics. The endocannabinoid system may play a role in the pathogenesis of ASD, making phytocannabinoids a potential effective treatment for core symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Emmanuel Costa, Vincent Joris, Geraldo Vaz, Susana Ferrao Santos, Riem El-Tahry, Thierry Duprez, Christian Raftopoulos
Summary: This study reported the results of an innovative surgical approach, the anterior trans-superior temporal gyrus approach, for selective amygdalohippocampectomy in patients with drug-refractory temporal lobe epilepsy. The approach was found to be feasible, fast, and safe, with a high rate of seizure freedom and minimal complications.
WORLD NEUROSURGERY
(2022)
Article
Behavioral Sciences
Dicle Buyuktaskin, Elvan Iseri, Esra Guney, Zafer Gunendi, Bulent Cengiz
Summary: This study demonstrates impaired sensory processing in ASD evaluated by STD and its lack of relationship with subjective sensory symptoms and daily difficulties.
Article
Neurosciences
Jan Benner, Julia Reinhardt, Markus Christiner, Martina Wengenroth, Christoph Stippich, Peter Schneider, Maria Blatow
Summary: We used co-registration of fMRI and MEG to investigate the temporal segregation of human auditory responses in musicians with and without absolute pitch. Our findings reveal a characteristic temporal hierarchy of auditory regions in relation to specific auditory abilities, supporting the hypothesis of serial processing from nonhuman studies.
Article
Nutrition & Dietetics
Saijun Huang, Xin Wang, Tao Sun, Hong Yu, Yanwei Liao, Muqing Cao, Li Cai, Xiuhong Li, Lizi Lin, Xi Su, Jin Jing
Summary: Previous studies have shown that exclusive breastfeeding is associated with lower odds of having ASD in children. This cross-sectional study conducted in seven cities in China found that toddlers with partial breastfeeding or without breastfeeding had higher odds of having ASD compared to those with exclusive breastfeeding.
Article
Clinical Neurology
J. L. Berman, D. Chudnovskaya, L. Blaskey, E. Kuschner, P. Mukherjee, R. Buckner, S. Nagarajan, W. K. Chung, E. H. Sherr, T. P. L. Roberts
AMERICAN JOURNAL OF NEURORADIOLOGY
(2016)
Article
Behavioral Sciences
Russell G. Port, William Gaetz, Luke Bloy, Dah-Jyuu Wang, Lisa Blaskey, Emily S. Kuschner, Susan E. Levy, Edward S. Brodkin, Timothy P. L. Roberts
Article
Computer Science, Artificial Intelligence
Yasser Ghanbari, Luke Bloy, Birkan Tunc, Varsha Shankar, Timothy P. L. Roberts, J. Christopher Edgar, Robert T. Schultz, Ragini Verma
MEDICAL IMAGE ANALYSIS
(2017)
Article
Neurosciences
Russell G. Port, Christopher Gajewski, Elizabeth Krizman, Holly C. Dow, Shinji Hirano, Edward S. Brodkin, Gregory C. Carlson, Michael B. Robinson, Timothy P. L. Roberts, Steven J. Siegel
NEUROBIOLOGY OF DISEASE
(2017)
Article
Neurosciences
Mark Mikkelsen, Peter B. Barker, Pallab K. Bhattacharyya, Maiken K. Brix, Pieter F. Buur, Kim M. Cecil, Kimberly L. Chan, David Y. -T. Chen, Alexander R. Craven, Koen Cuypers, Michael Dacko, Niall W. Duncan, Ulrike Dydak, David A. Edmondson, Gabriele Ende, Lars Ersland, Fei Gao, Ian Greenhouse, Ashley D. Harris, Naying He, Stefanie Heba, Nigel Hoggard, Tun-Wei Hsu, Jacobus F. A. Jansen, Alayar Kangarlu, Thomas Lange, R. Marc Lebel, Yan Li, Chien-Yuan E. Lin, Jy-Kang Liou, Jiing-Feng Lirng, Feng Liu, Ruoyun Maq, Celine Maes, Marta Moreno-Ortega, Scott O. Murray, Sean Noah, Ralph Noeske, Michael D. Noseworthy, Georg Oeltzschner, James J. Prisciandaro, Nicolaas A. J. Puts, Timothy P. L. Roberts, Markus Sack, Napapon Sailasuta, Muhammad G. Saleh, Michael-Paul Schallmo, Nicholas Simard, Stephan P. Swinnen, Martin Tegenthoff, Peter Truong, Guangbin Wang, Iain D. Wilkinson, Hans-Joerg Wittsack, Hongmin Xu, Fuhua Yan, Chencheng Zhang, Vadim Zipunnikov, Helge J. Zoellner, Richard A. E. Edden
Article
Neurosciences
Minhui Ouyang, Peiying Liu, Tina Jeon, Lina Chalak, Roy Heyne, Nancy K. Rollins, Daniel J. Licht, John A. Detre, Timothy P. L. Roberts, Hanzhang Lu, Hao Huang
Article
Neuroimaging
William Gaetz, Michael T. Jurkiewicz, Sudha Kilaru Kessler, Lisa Blaskey, Erin S. Schwartz, Timothy P. L. Roberts
NEUROIMAGE-CLINICAL
(2017)
Article
Behavioral Sciences
Junko Matsuzaki, Emily S. Kuschner, Lisa Blaskey, Luke Bloy, Mina Kim, Matthew Ku, James Christopher Edgar, David Embick, Timothy P. L. Roberts
Review
Radiology, Nuclear Medicine & Medical Imaging
Russell G. Port, Lindsay M. Oberman, Timothy P. L. Roberts
BRITISH JOURNAL OF RADIOLOGY
(2019)
Article
Neurosciences
Leighton B. N. Hinkley, Corby L. Dale, Tracy L. Luks, Anne M. Findlay, Polina Bukshpun, Nick Pojman, Tony Thieu, Wendy K. Chung, Jeffrey Berman, Timothy P. L. Roberts, Pratik Mukherjee, Elliott H. Sherr, Srikantan S. Nagarajan
JOURNAL OF NEUROSCIENCE
(2019)
Article
Genetics & Heredity
Timothy P. L. Roberts, Junko Matsuzaki, Lisa Blaskey, Luke Bloy, J. Christopher Edgar, Mina Kim, Matthew Ku, Emily S. Kuschner, David Embick
Article
Behavioral Sciences
Timothy P. L. Roberts, Luke Bloy, Matt Ku, Lisa Blaskey, Carissa R. Jackel, James Christopher Edgar, Jeffrey I. Berman
Review
Clinical Neurology
Timothy P. L. Roberts, Emily S. Kuschner, J. Christopher Edgar
Summary: This paper reviews a candidate biomarker for ASD, the M50 auditory evoked response component, detected by magnetoencephalography (MEG) and presents a position on the roles and opportunities for such a biomarker, as well as converging evidence from allied imaging techniques (magnetic resonance imaging, MRI and spectroscopy, MRS). Data is presented on prolonged M50 latencies in ASD as well as extension to include children with ASD with significant language and cognitive impairments in whom M50 latency delays are exacerbated. Modeling of the M50 latency by consideration of the properties of auditory pathway white matter is shown to be successful in typical development but challenged by heterogeneity in ASD; this, however, is capitalized upon to identify a distinct subpopulation of children with ASD whose M50 latencies lie well outside the range of values predictable from the typically developing model.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2021)
Article
Neurosciences
W. Gaetz, C. Dockstader, P. L. Furlong, S. Amaral, A. Vossough, E. S. Schwartz, T. P. L. Roberts, L. Scott Levin
Summary: A vascularized composite tissue allotransplantation (VCA) was performed on an 8-year-old patient at CHOP in 2015, resulting in the restoration of hand somatosensation and motor function. Magnetoencephalography (MEG) was used to assess cortical plasticity of the hands' sensory nerves. The results showed that the restoration of somatosensory input led to persistent and atypically large cortical responses to digit stimulation, which remained stable at 6 years post-transplant with no perceptual correlate or phantom pain reported.
Article
Genetics & Heredity
Raphael Bernier, Caitlin M. Hudac, Qixuan Chen, Chubing Zeng, Arianne Stevens Wallace, Jennifer Gerdts, Rachel Earl, Jessica Peterson, Anne Wolken, Alana Peters, Ellen Hanson, Robin P. Goin-Kochel, Stephen Kanne, LeeAnne Green Snyder, Wendy K. Chung
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2017)