Article
Behavioral Sciences
Hanaa Malloul, Sara Bonzano, Mohammed Bennis, Silvia De Marchis, Saadia Ba-M'hamed
Summary: Exposure to volatile solvents can affect olfactory functioning and behavior in mice, but alterations in adult olfactory neurogenesis do not seem to be associated with impaired olfactory performances in chronically exposed animals.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Ruilong Hu, Janam Shankar, Grant Z. Z. Dong, Pablo S. S. Villar, Ricardo C. C. Araneda
Summary: In the olfactory bulb (OB), noradrenaline (NA) modulates the hyperpolarization-activated currents (I-h) in adult-born granule cells (abGCs) through alpha(2)-adrenergic receptors (ARs), enhancing lateral inhibition onto mitral and tufted cells (MCs). This modulation also affects the subthreshold resonance in GCs, potentially impacting the temporal integration of abGCs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Paula Lunardi, Lara M. Z. Mansk, Laura F. Jaimes, Grace S. Pereira
Summary: Social memory is crucial in guiding behavior in a social context, with the hippocampus, especially the CA2 region, identified as a neural substrate for social memory. Olfactory bulb neural ensembles may also play a role in encoding social memory traces. While much remains to be explored in the neurobiological foundations of social memory, attention to neurogenesis is essential for further understanding.
BRAIN RESEARCH BULLETIN
(2021)
Article
Cell & Tissue Engineering
Cagla Defterali, Mireia Moreno-Estelles, Carlos Crespo, Eva Diaz-Guerra, Maria Diaz-Moreno, Eva Vergano-Vera, Vanesa Nieto-Estevez, Anahi Hurtado-Chong, Antonella Consiglio, Helena Mira, Carlos Vicario
Summary: In this study, injected EGFP-labeled retroviral particles in the adult olfactory bulb core of mice revealed that NSCs could generate multipotent neurons and glial cells. These newly generated neurons were able to establish synaptic contacts and be integrated into the olfactory bulb circuits.
Article
Neurosciences
Nadina M. Ferroni, Mariela J. Chertoff, Carolina D. Alberca, Bruno G. Berardino, Octavio Gianatiempo, Martin Brahamian, Valeria Levi, Leandro Urrutia, German Falasco, Eduardo T. Canepa, Silvina V. Sonzogni
Summary: This study aimed to determine whether perinatal protein malnutrition predisposes to premature aging in a murine model and to assess the cellular and molecular mechanisms involved. The results showed that protein malnutrition impaired spatial memory, coinciding with higher levels of oxidative stress and altered sirtuin expression in the hippocampus. Additionally, protein malnutrition led to the upregulation of senescence markers and the interruption of neuronal maturation.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Psychology, Multidisciplinary
Eric J. Leonardis, Leo Breston, Rhiannon Lucero-Moore, Leigh Sena, Raunit Kohli, Luisa Schuster, Lacha Barton-Gluzman, Laleh K. Quinn, Janet Wiles, Andrea A. Chiba
Summary: Interactive neurorobotics studies the brain's responses to robot interactions and their relationship with behavioral responses. It aims to gather rich neural and behavioral data from humans or animals responding to agents for the design of future social robots. The research focuses on studying how organisms respond to artificial agents in contrast to biological or inanimate ones. The experiment uses the unique capabilities of robotic platforms to investigate complex dynamics during minimally structured interactions that are difficult to capture with traditional experimental setups. The proposed framework emphasizes naturalistic interactions, multimodal observations, and complementary analysis pipelines to provide a holistic understanding of the data for informing robotic design principles. The approach is demonstrated with a rat-robot social interaction task that involves simultaneous multi-agent tracking and neural recordings.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ewelina Kurowska-Rucinska, Jan Rucinski, Dorota Myslinska, Beata Grembecka, Danuta Wrona, Irena Majkutewicz
Summary: The disorder of adult neurogenesis is considered an important mechanism underlying the learning and memory impairment observed in Alzheimer's disease (AD). This study found that DMF therapy can ameliorate the disruption of adult neurogenesis and BDNF-related neuroprotection in an STZ-ICV rat model of sAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Bunichiro Ogawa, Yutaka Nakanishi, Masaki Wakamatsu, Yasunori Takahashi, Makoto Shibutani
Summary: Acrylamide (AA) is a neurotoxicant that inhibits synaptic function and neural cell differentiation in the hippocampus and olfactory bulb-subventricular zone (OB-SVZ) region. AA exposure decreased neuroblasts in the OB by suppressing neuronal migration and downregulating genes related to neuronal differentiation and migration. These findings indicate that AA has a similar detrimental effect on neurogenesis in the OB-SVZ as it does in the hippocampus.
TOXICOLOGY LETTERS
(2023)
Review
Developmental Biology
Candida Tufo, Subathra Poopalasundaram, Ana Dorrego-Rivas, Marc C. Ford, Anthony Graham, Matthew S. Grubb
Summary: This review summarizes the development of the mammalian olfactory bulb, including prenatal, postnatal, and adult stages, focusing on the maturation, morphology, functions, and interactions of its diverse glutamatergic and GABAergic cell types. The review highlights the significant advances made in understanding olfactory bulb development in recent years, as well as the remaining gaps in knowledge that require urgent attention.
Article
Cell Biology
Chrysoula Dioli, Patricia Patricio, Lucilia-Goreti Pinto, Clemence Marie, Monica Morais, Sheela Vyas, Joao M. Bessa, Luisa Pinto, Ioannis Sotiropoulos
Summary: The study demonstrates the significant role of Tau in neurogenesis under chronic stress conditions, with Tau-KO mice showing higher levels of neuronal migration. These findings highlight the importance of Tau protein in neurogenesis suppression under stress, emphasizing its role in stress-related plasticity deficits.
CELL PROLIFERATION
(2021)
Article
Neurosciences
Anna Athanassi, Marine Breton, Laura Chalencon, Jerome Brunelin, Anne Didier, Kevin Bath, Nathalie Mandairon
Summary: Experiencing chronic stress increases the risk for depression and affects the quality of life. Odorants play a crucial role in social interactions and behavior, and a decrease in olfactory function is associated with depression symptoms. The hedonic value of odorants is encoded by granule cells in the olfactory bulb, which can be affected by chronic mild stress. This study explores the link between olfactory hedonics, neurogenesis, and stress-associated depression.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Francisco J. Fernandez Acosta, Inma Luque-Molina, Rebeca Vecino, Eva Diaz-Guerra, Cagla Defterali, Jaime Pignatelli, Carlos Vicario
Summary: This study found that neural stem cells in the olfactory bulb of adult mice can generate CalR(+) neurons, and these adult cells exhibit different morphologies when migrating to different layers of the olfactory bulb. The study also revealed that altering the expression of the transcription factor Tbr1 can affect the migration and morphology of these newly generated neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Kelsey E. Zuk, Hillary L. Cansler, Jinxin Wang, Julian P. Meeks
Summary: The accessory olfactory system (AOS) is crucial for social behavior development. In male and female mice, the accessory olfactory bulb (AOB) displays plasticity in response to social experience. Internal granule cells (IGCs) in the AOB express the immediate-early gene Arc after aggression or mating. This study investigates the role of Arc-expressing IGCs in the processing of territorial aggression. Results show that these IGCs become more excitable after resident-intruder interactions and play a significant role in ramping aggression exhibited by resident male mice.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Perla Leal-Galicia, Maria Elena Chavez-Hernandez, Florencia Mata, Jesus Mata-Luevanos, Luis Miguel Rodriguez-Serrano, Alejandro Tapia-de-Jesus, Mario Humberto Buenrostro-Jauregui
Summary: The generation of new neurons in the adult brain is a well-accepted phenomenon that mainly occurs in the subventricular zone and the hippocampal dentate gyrus. These new neurons are generated through an asymmetric division process and contribute to the local circuitry with their unique properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Angela del Aguila, Mike Adam, Kristy Ullom, Nicholas Shaw, Shenyue Qin, Jacqueline Ehrman, Diana Nardini, Joseph Salomone, Brian Gebelein, Q. Richard Lu, Steven S. Potter, Ronald Waclaw, Kenneth Campbell, Masato Nakafuku
Summary: The basic helix-loop-helix transcription factor Olig2 defines a unique subset of adult neural stem cells in the ventral aspect of the subventricular zone, playing an important role in cell cycle, metabolic properties, and specification of olfactory bulb interneuron subtypes.