Article
Clinical Neurology
Aurore Thibaut, Rajanikant Panda, Jitka Annen, Leandro R. D. Sanz, Lionel Naccache, Charlotte Martial, Camille Chatelle, Charlene Aubinet, Estelle A. C. Bonin, Alice Barra, Marie-Michele Briand, Benedetta Cecconi, Sarah Wannez, Johan Stender, Steven Laureys, Olivia Gosseries
Summary: A study investigated brain activity in non-responsive brain-injured patients, finding that a significant proportion of them showed partial preservation of brain metabolism, labeled as MCS*. Patients with MCS* had better outcomes, global functional connectivity, and grey matter preservation compared to those with VS/UWS. MCS* patients had lower brain metabolism in posterior brain regions compared to MCS patients.
ANNALS OF NEUROLOGY
(2021)
Review
Behavioral Sciences
Antonio I. Triggiani, Gabriel Kreiman, Cara Lewis, Uri Maoz, Alfred Mele, Liad Mudrik, Adina L. Roskies, Aaron Schurger, Mark Hallett
Summary: In 1983, Benjamin Libet and colleagues published a paper that challenged the idea that conscious intention to move comes before the brain's preparation for movement. This experiment sparked debates about intention, the neurophysiology of movement, and philosophical and legal notions of free will and moral responsibility. This review explores the concept of conscious intention and efforts to measure its timing. The Bereitschaftspotential, scalp electroencephalographic activity before movement, starts before the reported onset of conscious intent, but its interpretation remains controversial. Studies suggest that the Libet method for determining intent, W time, is not accurate and may lead to misleading results. It is concluded that intention has various aspects and despite a better understanding of how the brain generates movements, determining the time of conscious intention remains a challenge.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Anna Estraneo, Alfonso Magliacano, Salvatore Fiorenza, Rita Formisano, Antonello Grippo, Efthymios Angelakis, Helena Cassol, Aurore Thibaut, Olivia Gosseries, Gianfranco Lamberti, Enrique Noe, Sergio Bagnato, Brian L. Edlow, Camille Chatelle, Nicolas Lejeune, Vigneswaran Veeramuthu, Michelangelo Bartolo, Donatella Mattia, Jlenia Toppi, Nathan Zasler, Caroline Schnakers, Luigi Trojano
Summary: This study found that patients with prolonged disorders of consciousness have a high mortality rate within 24 months post-injury, with different predictors of mortality in patients with vegetative state/unresponsive wakefulness syndrome compared to those with minimally conscious state.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Biology
Sima Mofakham, Adam Fry, Joseph Adachi, Patricia L. Stefancin, Tim Q. Duong, Jordan R. Saadon, Nathan J. Winans, Himanshu Sharma, Guanchao Feng, Petar M. Djuric, Charles B. Mikell
Summary: This study investigates the role of thalamic input to the cortex in mediating cortical dynamics associated with the return of consciousness following traumatic brain injury. The findings suggest that thalamic injuries may lead to the formation of cortical attractors, highlighting the crucial role of thalamic input in supporting rich cortical dynamics related to consciousness.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Julia Nekrasova, Mikhail Kanarskii, Ilya Borisov, Pranil Pradhan, Denis Shunenkov, Alexey Vorobiev, Maria Smirnova, Vera Pasko, Marina V. Petrova, Elena Luginina, Igor Pryanikov
Summary: This study evaluates the prognostic value of demographical and clinical data in patients with severe acquired brain injury over a period of 12 months. Younger age and higher CRS-R scores predict better survival rates. Etiology plays a role in prognosis, with anoxic brain injury having the worst prognosis and the first three months post injury being crucial for patients with vascular lesions. Gender does not appear to influence outcomes.
Article
Clinical Neurology
Chengwei Xu, Wanchun Wu, Xiaochun Zheng, Qimei Liang, Xiyan Huang, Haili Zhong, Qiuyi Xiao, Yue Lan, Yang Bai, Qiuyou Xie
Summary: Recent studies have found that patients with disorders of consciousness (DoC) can benefit from repetitive transcranial magnetic stimulation (rTMS) therapy. The posterior parietal cortex (PPC) is important for consciousness and its effect on consciousness recovery needs further study.
FRONTIERS IN NEUROLOGY
(2023)
Article
Rehabilitation
David B. Arciniegas, Lindsey J. Gurin, Bei Zhang
Summary: Understanding the neuroanatomy of wakefulness and awareness is crucial for clinicians dealing with disorders of consciousness. Wakefulness is supported by brainstem-forebrain-diencephalic systems, while awareness is a result of integrated activity within and between wakefulness systems and cortical areas. Disruptions in these neural systems can inform the clinical presentation and treatment options for disorders of consciousness.
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Stefano Masiero, Humberto Antonio Cerrel Bazo, Marcello Rattazzi, Laura Bernardi, Marina Munari, Elisabetta Faggin, Manuela Cattelan, Paolo Pauletto, Alessandra Del Felice
Summary: The study protocol aims to develop prediction models for functional and cognitive outcomes in patients with severe acquired brain injury by collecting clinical data and various assessment measures, in order to identify early signs of favorable recovery during the acute phase.
NEUROLOGICAL SCIENCES
(2021)
Article
Business
Muthu De Silva, Pengji Wang, Adrian T. H. Kuah
Summary: The study found a positive relationship between consumers' awareness of green benefits and purchase intention, but individual consumption values significantly moderate this relationship in different cultural contexts of the United Kingdom and China.
JOURNAL OF BUSINESS RESEARCH
(2021)
Review
Clinical Neurology
Christen M. O'Neal, Lindsey N. Schroeder, Allison A. Wells, Sixia Chen, Tressie M. Stephens, Chad A. Glenn, Andrew K. Conner
Summary: The meta-analysis showed that transcranial magnetic stimulation (TMS) may improve outcomes in patients with minimally conscious state (MCS) and persistent vegetative state (PVS). Further randomized, clinical trials are needed to determine its efficacy in this patient population.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Andrea I. Luppi, Justine Y. Hansen, Ram Adapa, Robin L. Carhart-Harris, Leor Roseman, Christopher Timmermann, Daniel Golkowski, Andreas Ranft, Rudiger Llg, Denis Jordan, Vincent Bonhomme, Audrey Vanhaudenhuyse, Athena Demertzi, Oceane Jaquet, Mohamed Ali Bahri, Naji L. N. Alnagger, Paolo Cardone, Alexander R. D. Peattie, Anne E. Mantelow, Draulio B. de Araujo, Rudlger Ilg, Stefano L. Sensi, Adrian M. Owen, Lorina Naci, David K. Melon, Bratislav Misic, Emmanuel A. Stamatakis
Summary: In order to understand how pharmacological interventions affect brain function, this study investigates the relationship between the distribution of neurotransmitter receptors and transporters in the brain and the changes in functional connectivity induced by psychoactive drugs. The results show that there is a correlation between the effects of drugs on brain function and multiple neurotransmitter systems. Additionally, the effects of anesthetics and psychedelics are organized along hierarchical gradients of brain structure and function. The study also highlights the similarity between regional susceptibility to drug interventions and disorder-induced structural alterations.
Article
Multidisciplinary Sciences
Christoph Helmstaedter, Thorsten Rings, Lara Buscher, Benedikt Janssen, Sara Alaeddin, Vanessa Krause, Stefan Knecht, Klaus Lehnertz
Summary: This study successfully differentiated the brain network characteristics of patients with unresponsive wakefulness syndrome through a combination of EEG recordings, basal stimulation, and daily behavioral assessment, and showed the short-term and potential long-term recovery effects of personalized therapy.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Rossella Spataro, Yiyan Xu, Ren Xu, Giorgio Mandala, Brendan Z. Allison, Rupert Ortner, Alexander Heilinger, Vincenzo La Bella, Christoph Guger
Summary: This study compares the repetitive assessment of consciousness using clinical behavioral evaluations and Brain-Computer Interface (BCI) approaches. It finds that BCI approaches can detect command following earlier than clinical evaluations in some patients with disorders of consciousness. BCI active paradigms contribute to improving the diagnostic precision of clinical bedside assessments.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Benjamin Winters, Bruce Kuluris, Rita Pathmanaban, Hannelise Vanderwalt, Aurore Thibaut, Caroline Schnakers
Summary: This retrospective study investigated the development of spasticity in patients with prolonged DOC over a 21-month period, finding significant differences in spasticity evolution based on etiology and level of consciousness. The results suggest that spasticity in DOCs may be mediated by different mechanisms and require tailored treatment approaches. Future longitudinal studies in a larger cohort are needed to confirm these findings and better understand spasticity evolution in this population.
Article
Neurosciences
Yuanyuan Dang, Yong Wang, Xiaoyu Xia, Yi Yang, Yang Bai, Jianning Zhang, Jianghong He
Summary: This study demonstrated the efficacy of deep brain stimulation (DBS) in enhancing recovery from minimally conscious state (MCS) by improving functional connectivity and brain networks.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Florencia Jacobacci, Jorge Jovicich, Gonzalo Lerner, Edson Amaro Jr, Jorge L. Armony, Julien Doyon, Valeria Della-Maggiore
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2020)
Article
Multidisciplinary Sciences
Florencia Jacobacci, Jorge L. Armony, Abraham Yeffal, Gonzalo Lerner, Edson Amaro Jr, Jorge Jovicich, Julien Doyon, Valeria Della-Maggiore
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Sport Sciences
Thomas Zandonai, Darias Holgado, Luis F. Ciria, Mikel Zabala, James Hopker, Tristan Bekinschtein, Daniel Sanabria
Summary: The study found that using 100 mg of tramadol in cycling can increase mean power output, accelerate reaction time, and raise heart rate, but did not demonstrate any superiority of tramadol over placebo in cycling time trials.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Multidisciplinary Sciences
Andres Canales-Johnson, Renzo C. Lanfranco, Juan Pablo Morales, David Martinez-Pernia, Joaquin Valdes, Alejandro Ezquerro-Nassar, Alvaro Rivera-Rei, Agustin Ibanez, Srivas Chennu, Tristan A. Bekinschtein, David Huepe, Valdas Noreika
Summary: The study found that voluntary visual imagery of faces is associated with long-range phase synchronisation in the gamma frequency range, which predicts subjective ratings of the contour definition of imagined faces. Additionally, short-range frontal synchronisation in the theta frequency range occurs before the long-range increase in gamma synchronisation, potentially related to a top-down mnemonic reactivation of faces.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Serena Defina, Maria Niedernhuber, Nicholas Shenker, Christopher A. Brown, Tristan A. Bekinschtein
Summary: Research on the neurophysiological and neurocognitive changes in patients with complex regional pain syndrome (CRPS) highlighted differences in EEG modulations evoked by touch. Early cortical decodability reduction distinguished CRPS patients from healthy controls, while an unexpected increase in decodability in the later stage was observed in the CRPS group, driven mainly by the affected side.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Correction
Multidisciplinary Sciences
Andres Canales-Johnson, Renzo C. Lanfranco, Juan Pablo Morales, David Martinez-Pernia, Joaquin Valdes, Alejandro Ezquerro-Nassar, Alvaro Rivera-Rei, Agustin Ibanez, Srivas Chennu, Tristan A. Bekinschtein, David Huepe, Valdas Noreika
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Agustin Solano, Luis A. Riquelme, Daniel Perez-Chada, Valeria Della-Maggiore
Summary: Recent studies have shown that traditional declarative structures play a role in the encoding and consolidation of procedural memories. These studies have also found converging physiological pathways across memory systems. In this study, we investigated the connection between slow oscillations and spindles in the stabilization of human motor memories. The results suggest that this coupling is relevant for motor memory consolidation.
Article
Behavioral Sciences
Luis F. Ciria, Marta Suarez-Pinilla, Alex G. Williams, Sridhar R. Jagannathan, Daniel Sanabria, Tristan A. Bekinschtein
Summary: Humans have the unique ability to adapt to changing environments by updating information and adjusting behavior, with cognitive flexibility being modulated differently by high and low arousal fluctuations. Low arousal leads to increased decision volatility and decreased behavioral performance, while high arousal results in increased perseverative behavior and performance decline.
Article
Neurosciences
Sridhar R. Jagannathan, Corinne A. Bareham, Tristan A. Bekinschtein
Summary: This study used EEG and behavioral modeling to examine the cognitive and neural dynamics of decision-making in awake and low-alertness states in humans. The results showed that during periods of low alertness, reaction times were slower, attention to the left side of space decreased, and the rate of evidence accumulation was lower. Additionally, there was a delay in the neural signatures distinguishing between left and right decisions and a spatial reconfiguration of neural activity. These findings reveal the mechanisms of cognitive resilience in the face of decreased alertness.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Scott T. Albert, Jihoon Jang, Shanaathanan Modchalingam, Bernard Marius 't Hart, Denise Henriques, Gonzalo Lerner, Valeria Della-Maggiore, Adrian M. Haith, John W. Krakauer, Reza Shadmehr, Kunlin Wei
Summary: Sensorimotor learning involves both explicit and implicit systems, which interact and compete for resources during the learning process. Strategies and conditions can affect the stability and characteristics of implicit learning.
Article
Neurosciences
Agustin Solano, Luis A. Riquelme, Daniel Perez-Chada, Valeria Della-Maggiore
Summary: Sleep spindles and slow oscillations are synchronized during sleep and play a role in memory consolidation. Our research shows that visuomotor adaptation learning increases the density of spindles and their coupling with slow oscillations, which predicts overnight memory retention. We also found that spindles grouped in a cluster have higher amplitude and duration, suggesting a biological advantage of this temporal arrangement.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Chiara Avancini, Sally Jennings, Srivas Chennu, Valdas Noreika, April Le, Tristan A. Bekinschtein, Madeleine J. Walpert, Isabel C. H. Clare, Anthony J. Holland, Shahid H. Zaman, Howard Ring
Summary: This study characterized the electrophysiological markers of local and global predictive processes in individuals with Down's syndrome. The results showed that the predictive processes of auditory violation detection are preserved in individuals with Down's syndrome, but the sensitivity to local deviancies decreases with age. However, these electrophysiological markers did not predict subsequent cognitive decline in Down's syndrome patients.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Maria Niedernhuber, Federico Raimondo, Jacobo D. Sitt, Tristan A. Bekinschtein
Summary: To ensure survival in a dynamic environment, the human neocortex monitors input streams from different sensory organs for important sensory events. This study investigates the principles governing whether different senses share common or modality-specific brain networks for sensory target detection. The findings suggest that complex targets evoke sustained supramodal activity while simple targets rely on modality-specific networks with short-lived supramodal contributions. Each sense implements a cortical hierarchy orchestrating supramodal target detection responses, which operate at different timescales in successive processing stages.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Christine Blume, Maria Niedernhuber, Manuel Spitschan, Helen C. Slawik, Martin P. Meyer, Tristan A. Bekinschtein, Christian Cajochen
Summary: Presleep exposure to short-wavelength light suppresses melatonin and decreases sleepiness, but does not have a significant impact on sleep quality and vigilance. The light exposure does not differentially modulate sensory processing. An interaction between melanopsin and cone-rod signals may need to be considered.
Article
Neurosciences
Alvaro Deleglise, Patricio Andres Donnelly-Kehoe, Abraham Yeffal, Florencia Jacobacci, Jorge Jovicich, Edson Amaro Jr, Jorge L. Armony, Julien Doyon, Valeria Della-Maggiore
Summary: Recent research suggests that the hippocampus plays an important role in the reactivation and consolidation of motor memory, as indicated by tracking brain functional connectivity. The findings also highlight the relevance of the hippocampus in the early stages of motor memory consolidation.