Review
Biochemistry & Molecular Biology
Kumar Rishabh, Soham Khadilkar, Aviral Kumar, Ishu Kalra, Alan Prem Kumar, Ajaikumar B. Kunnumakkara
Summary: Oral cancers have a high incidence and low survival rate in developing countries, highlighting the need for further research on their etiology, diagnosis, and treatment. MicroRNAs have been associated with various human diseases, including oral cancers, and could serve as potential candidates for functional markers to aid in differential diagnosis, prognosis, and development of novel therapeutic regimens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Zirui Jia, Jiacheng Gao, Yuhang Wang, Tingting Zhou, Xiangwen Zhang, Guo Zu
Summary: Through meta-analysis and bioinformatics analysis, the study investigated the relationship between LOX expression and methylation level with clinicopathological parameters and prognosis in GC patients. Results showed that LOX expression was related to lymph node metastasis, tumor distant metastasis, and poor prognosis, while low methylation levels were associated with advanced tumor stage and poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jiazhan Mei, Guiju Liu, Ruijun Li, Peng Xiao, Dan Yang, Hua Bai, Yibin Hao
Summary: The study revealed that lncRNA SNHG6 has inhibitory effects on DDP resistance and progression of GC by sponging miR-1297 and regulating BCL-2 expression.
BIOSCIENCE REPORTS
(2021)
Review
Oncology
Amir Abbas Hamidi, Negin Taghehchian, Zahra Basirat, Amir Sadra Zangouei, Meysam Moghbeli
Summary: Thyroid cancer is a common endocrine malignancy, with a higher prevalence in females. Tumor recurrence is a significant clinical manifestation in differentiated thyroid cancer, and it is influenced by factors such as age, tumor size, and histological features. Molecular processes like genetic and epigenetic modifications, as well as non-coding RNAs, are also involved in the progression and metastasis of thyroid cancer.
BIOMARKER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yiyang Hu, Chunli Gong, Zhibin Li, Jiao Liu, Yang Chen, Yu Huang, Qiang Luo, Sumin Wang, Yu Hou, Shiming Yang, Yufeng Xiao
Summary: This study established an ALKBH5-PKMYT1-IGF2BP3 regulation system in metastasis, providing a new therapeutic target for gastric cancer metastasis.
Review
Oncology
Jing Ouyang, Zhizhong Xie, Xiaoyong Lei, Guotao Tang, Runliang Gan, Xiaoyan Yang
Summary: miRNAs have been shown to be closely linked to gastric cancer, affecting various aspects of the disease including oncogenesis, development, diagnosis, treatment, and prognosis. However, there is still limited research on the clinical application of miRNAs in the context of gastric cancer, with further studies needed to explore their potential in clinical practice.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Oncology
Lei Jiang, Yan Chen, Guangtao Min, Jun Wang, Wei Chen, Hongpeng Wang, Xiangwen Wang, Nan Yao
Summary: BAG4 has been found to be overexpressed in gastric cancer tissues compared to normal tissues, and its elevated expression is associated with advanced tumor characteristics and poor patient outcomes. Mechanistically, BAG4 promotes invasion and metastasis of gastric cancer cells by activating the PI3K/AKT/NF-kappa B/ZEB1 axis to induce epithelial-mesenchymal transition.
Article
Oncology
You Hu, Bin Yi, Xin Chen, Lu Xu, Xiaojun Zhou, Xinguo Zhu
Summary: miR-223 overexpression is associated with tumor progression in gastric cancer by targeting RhoB. It may serve as a potential biomarker for predicting gastric cancer.
JOURNAL OF ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Iolanda Scognamiglio, Lorenza Cocca, Ilaria Puoti, Francesco Palma, Francesco Ingenito, Cristina Quintavalle, Alessandra Affinito, Giuseppina Roscigno, Silvia Nuzzo, Rosario Vincenzo Chianese, Stefania Belli, Guglielmo Thomas, Timo Schomann, Alan Chan, Maria Patrizia Stoppelli, Gerolama Condorelli
Summary: Research has shown that exosomes derived from triple-negative breast cancer cells can activate normal fibroblasts and transform them into cancer-associated fibroblasts, thereby promoting tumor invasion. These findings highlight the significant role of breast cancer cells in remodeling the tumor microenvironment and contributing to tumor evolution.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Cell Biology
Arghavan Zebardast, Sadra S. Tehrani, Tayebeh Latifi, Farzin Sadeghi
Summary: EBV-encoded miRNAs play a crucial role in the pathogenesis of EBVaGC, participating in carcinogenesis and the progression of malignancies by regulating gene expression and other activities.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Anatomy & Morphology
Xiangwen Zhang, Jiaming Xue, Huiliang Yang, Tingting Zhou, Guo Zu
Summary: TNFAIP6 plays an important role in the prognosis of gastric cancer patients, with higher expression levels associated with tumor invasion depth, lymph node metastasis, TNM stage, and poorer overall survival. Knockdown of TNFAIP6 inhibited proliferation, invasion, and metastasis of gastric cancer cells in vitro.
Review
Oncology
Yue Deng, Sicheng Cai, Jian Shen, Huiming Peng
Summary: Tetraspanins play diverse roles in the progression of gastric cancer, including promoting or inhibiting cell proliferation and invasion, regulating cell motility, and impacting lymph node metastasis. They also have significant clinical implications in therapeutic targeting, drug resistance development, and prognosis prediction for gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fengxiang Zhang, Huaxian Chen, Dandong Luo, Zhizhong Xiong, Xianzhe Li, Shi Yin, Longyang Jin, Shi Chen, Junsheng Peng, Lei Lian
Summary: Lymphovascular invasion (LVI) and perineural invasion (PNI) are associated with poorer prognosis in gastric cancer (GC). This study aimed to investigate their prognostic value in curative resected GC patients. The incidence of LVI/PNI was significantly higher in GC patients compared to colorectal cancer patients (50.54% vs. 21.91%, p < 0.001). LVI/PNI was closely associated with disease progression and served as an independent risk factor for lymph node metastasis and overall survival in GC.
Article
Cell Biology
Huaiping Cui, Zhaoyu Jiang, Shujie Zeng, Hao Wu, Zihao Zhang, Xiaobo Guo, Kangdi Dong, Jinshen Wang, Liang Shang, Leping Li
Summary: In this study, a novel lncRNA WFDC21P derived from pseudogenes was identified and found to promote proliferation and metastasis of gastric cancer cells by activating the Akt/GSK3 beta/beta-catenin pathway. It may serve as a potential biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Mei Zhang, Hong-chun Xian, Li Dai, Ya-ling Tang, Xin-hua Liang
Summary: Perineural invasion (PNI) is a common clinical feature in malignant tumors that can lead to postoperative recurrence and metastasis. Recent studies have shown that miRNA plays a crucial role in regulating PNI, offering potential new biomarkers and therapeutic targets for cancer treatment.
CELL AND BIOSCIENCE
(2021)
