Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 16, Issue -, Pages 1109-1131Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3738
Keywords
Myb; Oncogene; Stem Cells; Hematopoiesis; Transformation; Transcription; Post-Translational Modifications; Protein-Protein Interactions; SND1; cell cycle; SANT domain; Review
Categories
Funding
- USPHS/NIH [CA058443, CA105257]
- NATIONAL CANCER INSTITUTE [R01CA105257, R01CA058443] Funding Source: NIH RePORTER
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A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor regulates the expression of hundreds of genes and is in turn regulated by numerous pathways and protein interactions. However, the most unique feature of c-Myb is that it can be converted into an oncogenic transforming protein through a few mutations that completely change its activity and specificity. The c-Myb protein is a myriad of interactions and activities rolled up in a protein that controls proliferation and differentiation in many different cell types. Here we discuss the background and recent progress that have led to a better understanding of this complex protein, and outline the questions that have yet to be answered.
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