Article
Clinical Neurology
Shahram Bahrami, Guy Hindley, Bendik Slagsvold Winsvold, Kevin S. O'Connell, Oleksandr Frei, Alexey Shadrin, Weiqiu Cheng, Francesco Bettella, Linn Rodevand, Ketil J. Odegaard, Chun C. Fan, Matti J. Pirinen, Heidi M. Hautakangas, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Summary: Migraine shows a certain level of shared genetic basis with bipolar disorder, depression, and schizophrenia, with some shared genetic loci. It is less polygenic compared to mental disorders and shares variants with intelligence and educational attainment. Specific loci were identified that are jointly associated with migraine and depression, as well as with migraine and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for further research.
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Nutrition & Dietetics
Ting Liu, Kunhong Deng, Ying Xue, Rui Yang, Rong Yang, Zhicheng Gong, Mimi Tang
Summary: Depression is one of the most common mental diseases, but its understanding is insufficient. The relationship between carnitine and depression has been confirmed in multiple studies, and the level of acylcarnitines can serve as biomarkers for depression, while supplementing acetyl-L-carnitine is beneficial for the treatment of depression.
FRONTIERS IN NUTRITION
(2022)
Article
Psychiatry
Aidin Abbaspour, Masoud Bahreini, Sherafat Akaberian, Kamran Mirzaei
Summary: The study found that most patients with psychiatric disorders were affected by ineffective parenting styles. Despite the involvement of several bio-psycho-social factors in the development of psychiatric disorders, the crucial roles of parents, especially mothers, should not be ignored. It was suggested that parents and parental bonding were important and fundamental factors for mental health promotion.
Article
Psychiatry
Tuyen T. Le, Joshua D. Di Vincenzo, Kayla M. Teopiz, Yena Lee, Danielle S. Cha, Leanna M. W. Lui, Nelson B. Rodrigues, Roger C. Ho, Bing Cao, Kangguang Lin, Flora Nasri, Hartej Gill, Orly Lipsitz, Mehala Subramaniapillai, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger S. McIntyre
Summary: Psychotic depression is a severe subtype of major depressive disorder with high relapse and mortality rates. Ketamine may be an alternative pharmacotherapy, but its efficacy and safety in patients with psychotic depression have not been established.
PSYCHIATRY RESEARCH
(2021)
Article
Health Care Sciences & Services
Dror Ben-Zeev, Ayesha Chander, Justin Tauscher, Benjamin Buck, Subigya Nepal, Andrew Campbell, Guy Doron
Summary: This study conducted a fully remote randomized waitlist-controlled trial of CORE, a smartphone intervention for people with serious mental illness (SMI). Results showed that CORE was highly usable and acceptable, with significant reductions in psychiatric symptoms and disability levels, as well as improvements in recovery and self-esteem.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Psychiatry
Sophie-Kathrin Kirchner, Michael Lauseker, Kristina Adorjan, Heike Anderson-Schmidt, Ion-George Anghelescu, Bernhardt T. Baune, Monika Budde, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Peter Falkai, Christian Figge, Katrin Gade, Urs Heilbronner, Lena Hiendl, Georg Juckel, Janos L. Kalman, Farahnaz Kloehn-Saghatolislam, Carsten Konrad, Fabian U. Lang, Mojtaba Oraki Kohshour, Sergi Papiol, Daniela Reich-Erkelenz, Jens Reimer, Eva Z. Reininghaus, Sabrina K. Schaupp, Max Schmauss, Andrea Schmitt, Eva Christina Schulte, Simon Senner, Carsten Spitzer, Thomas Vogl, Joerg Zimmermann, Alkomiet Hasan, Thomas G. Schulze, Fanny Senner
Summary: This study comprehensively evaluates the association of sociodemographic, clinical, personality, and quality of life related factors with medication adherence by analyzing data from the PsyCourse study. The results show that never having used illicit drugs, the number of prescribed antipsychotics, the personality trait conscientiousness, and the environmental domain of quality of life have the strongest association with medication adherence.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Bhupendra Khobragade, Vikas Sharma, Smita N. Deshpande
Summary: The cognitive effects of tobacco use among women with schizophrenia, bipolar disorder, or depression have not been extensively studied. However, a study found that female tobacco users in these groups demonstrated poorer cognitive functioning and smoking may exacerbate cognitive dysfunction associated with major mental illnesses among women.
PSYCHIATRY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Nina Vindegaard Sorensen, Beate Holmelund Frandsen, Sonja Orlovska-Waast, Terkild Brink Buus, Niels Odum, Rune Haubo Christensen, Michael Eriksen Benros
Summary: This study systematically evaluated the circulating immune cells in blood and cerebrospinal fluid (CSF) from patients with unipolar depression compared to healthy controls. The findings suggest that patients with depression have higher overall leukocyte count, higher neutrophil count, higher monocyte count, and significant alterations in lymphocyte subsets. These immune cell alterations may be related to depression severity.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Deepiksana Keerthy, Joht Singh Chandan, Juste Abramovaite, Krishna Margadhamane Gokhale, Siddhartha Bandyopadhyay, Ed Day, Steven Marwaha, Matthew R. Broome, Krishnarajah Nirantharakumar, Clara Humpston
Summary: This study investigates the relationship between cannabis exposure and the risks of mental illness diagnoses or treatment and finds that cannabis exposure is associated with an increased risk of developing mental health disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Anton Shkundin, Angelos Halaris
Summary: This review article comprehensively discusses the significance of single nucleotide polymorphisms (SNPs) in the brain-derived neurotrophic factor (BDNF) and BDNF antisense RNA (BDNF-AS) genes in psychiatric conditions, specifically focusing on their associations with depression, schizophrenia, and bipolar disorder. The variations in these genes, as well as their interactions with environmental factors and other genes, can alter brain structure and function, shaping vulnerability to mental health disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Wedad Alhassen, Siwei Chen, Marquis Vawter, Brianna Kay Robbins, Henry Nguyen, Thant Nyi Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli, Pierre Baldi, Amal Alachkar
Summary: The study found that cilia genes play an important role in the pathogenesis of psychiatric disorders, with dysfunction potentially contributing to multiple disorders. Notably, cilia GPCRs genes and transition zone proteins were particularly affected in schizophrenia. This research provides new insights into the pathophysiology of these disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Immunology
Tracy Bhikram, Paul Sandor
Summary: The review found that NLR is elevated in certain adult psychiatric disorders like schizophrenia, major depressive disorder, and bipolar disorder, but the associations with symptom severity and clinical parameters are not entirely clear. Results in youth populations are similar to those in adults, indicating a need for further research to better understand the relationship between NLR and specific psychiatric disorders. Future work is required to determine the neuroinflammatory mechanisms underlying these disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Benjamin Perry, Rachel Upthegrove, Nils Kappelmann, Peter B. Jones, Stephen Burgess, Golam M. Khandaker
Summary: The study suggests potential causal associations between IL-6 and schizophrenia as well as depression, and highlights the need for replication in larger samples. Some findings did not survive correction for multiple testing, emphasizing the importance of further research in this area.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Pharmacology & Pharmacy
Vincenzo Micale, Martina Di Bartolomeo, Serena Di Martino, Tibor Stark, Bernardo Dell'Osso, Filippo Drago, Claudio D'Addario
Summary: The etiopathogenesis of mental disorders involves multiple genetic factors and a tight association between genes and environmental risk factors mediated by epigenetic mechanisms. Epigenetic modifications such as DNA methylation, histone modification, and interference of microRNA or long non-coding RNA have been found to influence the severity of the disease and the outcome of therapy. Understanding these mechanisms can help identify vulnerable patients and serve as biomarkers for diagnosis and treatment of psychiatric disorders.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Psychiatry
Brian Dean, Andrew Tsatsanis, Linh Q. Lam, Elizabeth Scarr, James A. Duce
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2020)
Article
Neurosciences
Robin F. Chan, Gustavo Turecki, Andrey A. Shabalin, Jerry Guintivano, Min Zhao, Lin Y. Xie, Gerard van Grootheest, Zachary A. Kaminsky, Brian Dean, Brenda W. J. H. Penninx, Karolina A. Aberg, Edwin J. C. G. van den Oord
BIOLOGICAL PSYCHIATRY
(2020)
Article
Psychiatry
Andrew S. Gibbons, Daniel Hoyer, Brian Dean
Summary: A recent study found decreased mRNA expression of SMAD2 and SMAD4 in the dorsolateral prefrontal cortex (DLPFC) of subjects with schizophrenia. Further investigation revealed lower levels of SMAD4 protein in the cortex of schizophrenia subjects, suggesting abnormalities in cortical TGFB-superfamily signalling in schizophrenia.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Kayoko Esaki, Shabeesh Balan, Yoshimi Iwayama, Chie Shimamoto-Mitsuyama, Yoshio Hirabayashi, Brian Dean, Takeo Yoshikawa
SCHIZOPHRENIA BULLETIN
(2020)
Article
Psychiatry
Brian Dean, Geoffrey Pavey, Elizabeth Scarr
SCHIZOPHRENIA RESEARCH
(2020)
Article
Neurosciences
Chie Shimamoto-Mitsuyama, Akihiro Nakaya, Kayoko Esaki, Shabeesh Balan, Yoshimi Iwayama, Tetsuo Ohnishi, Motoko Maekawa, Tomoko Toyota, Brian Dean, Takeo Yoshikawa
Summary: The study revealed lipid abnormalities in the corpus callosum of patients with schizophrenia and proposed the potential role of an impaired NFATC2-relevant gene network-microglial axis as its underlying mechanism.
Article
Psychiatry
Andrea Gogos, Jeehae Sun, Madhara Udawela, Andrew Gibbons, Maarten van den Buuse, Elizabeth Scarr, Brian Dean
Summary: The study found alterations in RAPGEF1 expression in the BA 8 of subjects with schizophrenia, but no differences in BA 8 and 44. Suicide completers had higher RAPGEF1 levels compared to non-suicide schizophrenia subjects in BA 8. Further investigation into the function of RAPGEF1 may provide insights into the pathophysiology of schizophrenia.
PSYCHIATRY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Lucy J. Brooks, Melanie P. Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael Ellis, Zane Jaunmuktane, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Peter B. Dirks, Samuel Marguerat, Simona Parrinello
Summary: The study reveals that glioblastoma cells infiltrating into the white matter acquire a pre-oligodendrocyte-like fate, leading to decreased proliferation and invasion of tumors. This differentiation is a response to white matter injury, driven by the upregulation of SOX10. Additionally, the study suggests that exploiting this latent program may offer treatment opportunities for a subset of patients.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Tamaki Ishima, Sebastian Illes, Yoshimi Iwayama, Brian Dean, Takeo Yoshikawa, Hans Agren, Keiko Funa, Kenji Hashimoto
Summary: The study found that BDNF mRNA expression was decreased in iPSC from bipolar disorder patients but increased in NSC, while BDNF-AS mRNA expression showed no changes between the two groups. Additionally, there was a significant decrease in BDNF mRNA expression in certain brain regions of bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Brian Dean, Elizabeth Scarr
Summary: Studies show low levels of cortical muscarinic M1 receptors (CHRM1) in schizophrenia patients, affecting gene expression. Changes in cortical gene expression in Chrm1(-/-) mice are linked to schizophrenia pathology and Alzheimer's disease. Additionally, genes affected by CHRM1-mediated changes in gene expression are associated with cognitive ability in humans.
Article
Medicine, Research & Experimental
Winston Lee, Jana Zernant, Pei-Yin Su, Takayuki Nagasaki, Stephen H. Tsang, Rando Allikmets
Summary: This study provides a structured understanding of the genetic and clinical landscape of ABCA4 disease through genotype-phenotype correlation analysis, and adds a tool to quantitatively assess individual genotype-specific prognoses in patients.
Review
Psychiatry
Megan Snelleksz, Susan L. Rossell, Andrew Gibbons, Jess Nithianantharajah, Brian Dean
Summary: Research suggests that the frontal pole is significantly impacted in schizophrenia, with more gene expression changes compared to other brain regions. The frontal pole is essential for higher cognitive functions and has extensive connections with various brain regions. Dysfunction in the frontal pole plays a crucial role in the pathophysiology of schizophrenia, with structural, cellular, and molecular abnormalities contributing to the symptoms of the disorder.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Brian Dean, Elizabeth H. X. Thomas, Kiymet Bozaoglu, Eric J. Tan, Tamsyn E. Van Rheenen, Erica Neill, Philip J. Sumner, Sean P. Carruthers, Elizabeth Scarr, Susan L. Rossell, Caroline Gurvich
Summary: Studying the working memory deficit phenotype within the syndrome of schizophrenia and its gene expression changes is significant for understanding the molecular pathology of the disorder and developing personalized medicine.
PSYCHIATRY RESEARCH
(2022)
Review
Neurosciences
Lucy J. Brooks, Holly Simpson Ragdale, Ciaran Scott Hill, Melanie Clements, Simona Parrinello, Samantha Dickson
Summary: Glioblastoma is the most common and aggressive primary brain cancer in adults, with poor therapeutic outcomes. Recent advances in understanding its underlying biology have revealed the interplay between tumor development and neuronal development as well as injury responses, which play crucial roles in tumor growth, invasion, and treatment resistance.
TRENDS IN NEUROSCIENCES
(2022)
Article
Pharmacology & Pharmacy
Brian Dean
Summary: Schizophrenia is a syndrome that requires drugs targeting muscarinic M1 and M4 receptors, rather than dopamine D2 receptors, as antipsychotic drugs do. It would be ideal to identify individuals who respond to drugs activating the CHRM1 and 4 receptors, as non-response to treatment could be restricted to specific sub-groups within the syndrome.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
