Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 14, Issue -, Pages 929-U6Publisher
BIOSCIENCE RESEARCH INST-BRI
DOI: 10.2741/3287
Keywords
CD157; ADP-ribosyl cyclase; Ectoenzyme; Transendothelial Migration; Neutrophil; Inflammation; Review
Categories
Funding
- AIRC (the Italian Association for Cancer Research)
- Ministry for Education, Universities and Research
- Ricerca Sanitaria Finalizzata e Ricerca Scientifica Applicata (Regione Piemonte)
- Compagnia SanPaolo ( Torino, Italy)
- FIRMS ( International Foundation for Research in Experimental Medicine)
Ask authors/readers for more resources
CD157 is a glycosylphosphatidylinositol-anchored molecule encoded by a member of the CD38/ADP-ribosyl cyclase gene family, involved in the metabolism of NAD. Expressed mainly by cells of the myeloid lineage and by vascular endothelial cells, CD157 has a dual nature behaving both as an ectoenzyme and as a receptor. Although it lacks a cytoplasmic domain, and cannot transduce signals on its own, the molecule compensates for this structural limit by interacting with conventional receptors. Recent experimental evidence suggests that CD157 orchestrates critical functions of human neutrophils. Indeed, CD157-mediated signals promote cell polarization, regulate chemotaxis induced through the high affinity fMLP receptor and control transendothelial migration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available