Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 13, Issue -, Pages 2495-2503Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2861
Keywords
apoptosis; caspase; apoptosis inducing factor; heart; autophagy; review
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Funding
- NHLBI NIH HHS [HL67091, HL65742] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL065742, K08HL067091] Funding Source: NIH RePORTER
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Apoptosis plays an important role in various cardiovascular diseases, and inhibition of cardiac apoptosis shows promise as a therapeutic strategy. Caspase, a critical enzyme in the induction and execution of apoptosis, has been targeted to inhibit apoptosis. However a newly recognized caspase-independent apoptosis pathway may also play an important role in cardiac apoptosis. Yet the mechanism and the potential significance of caspase-independent apoptosis in the heart remain poorly understood. In this paper, we reviewed the literatures on the mechanism of caspase-independent apoptosis and its significance in cardiovascular diseases.
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