Journal
FREE RADICAL RESEARCH
Volume 47, Issue 6-7, Pages 488-497Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2013.770150
Keywords
Claulansine F; neurodegenerative diseases; apoptosis; reactive oxygen species; hydroxyl radical
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Funding
- National Natural Science Foundation of China [U832008, 30973887, 81274122, 81073078]
- Special Purpose for New Drug Development [2012ZX09301002-004]
- Studies on Structure and function of Bioactive Substabces from Natural Medicines [IRT1007]
- Natural Science Foundation of Beijing [7131013]
- Ministry of Education of China [20121106130001]
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Reactive oxygen species (ROS) are known to be involved in many neurodegenerative diseases. This study assessed the effect of Claulansine F, a new carbazole isolated from Clausena lansium, on sodium nitroprusside (SNP)-treated rat pheochromocytoma PC12 cells. First, it was found that Claulansine F showed more potential on inhibiting the programmed death of PC12 cells than edaravone by cell viability, morphologic observation, and flow cytometric analysis. Further results also showed that Claulansine F attenuated the production of total intracellular ROS formation and lipid peroxidation in PC12 cells, inhibited the mitochondrial membrane potential (MMP) loss, and prevented the programmed cell death event via the P53/Bcl-2 family pathway. Its protective effect was likely medicated by the hydroxyl radical ((OH)-O-center dot) scavenging ability, as it appeared to be not involved in the natural antioxidant system. These results suggested a promising potential for Claulansine F as a ROS scavenger in pathologies, where an oxidative stress is involved. Keywords: Claulansine F, neurodegenerative diseases, apoptosis, reactive oxygen species
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