p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species

SnapShot: p38 MAPK Substrates

(2013) Natalia Trempolec et al.   CELL

SnapShot: p38 MAPK Signaling

(2013) Natalia Trempolec et al.   CELL

Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation

(2012) Thu H. Truong et al.   BIOCHEMISTRY

p38  Inhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species

(2012) T. Sakurai et al.   CANCER RESEARCH

Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts

(2012) Dagmar Faust et al.   Cell Communication and Signaling

Liver-specific p38α deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice

(2012) Ana M. Tormos et al.   HEPATOLOGY

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

(2012) Tina M. Thornton et al.   International Journal of Biological Sciences

The NF-κB Subunit RelA/p65 Is Dispensable for Successful Liver Regeneration after Partial Hepatectomy in Mice

(2012) Marc Ringelhan et al.   PLoS One

Therapeutic targets in the ASK1-dependent stress signaling pathways

(2012) Ryoichi HAYAKAWA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

MAPKs and NF-κB differentially regulate cytokine expression in the diaphragm in response to resistive breathing: the role of oxidative stress

(2011) Ioanna Sigala et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Oxidative stress-induced formation of a positive-feedback loop for the sustained activation of p38 MAPK leading to the loss of cell division in cardiomyocytes soon after birth

(2011) Daisuke Matsuyama et al.   BASIC RESEARCH IN CARDIOLOGY

ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation

(2011) Xin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor suppressor genes and ROS: complex networks of interactions

(2011) Beyza Vurusaner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

(2010) O. Bermudez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

PPARδ agonist-mediated ROS stimulates mouse embryonic stem cell proliferation through cooperation of p38 MAPK and Wnt/β-catenin

(2010) A Young Jeong et al.   CELL CYCLE

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inactivation of p38 MAPK during liver regeneration

(2010) Jean S. Campbell et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation

(2010) Youhong Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability

(2010) Daniela Frasca et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

(2009) Geoffrey Gloire et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways

(2009) Salvatore Papa et al.   BIOLOGICAL CHEMISTRY

Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells

(2009) Wayne Y.W. Lee et al.   CANCER LETTERS

Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect

(2009) W. Zhao et al.   CARCINOGENESIS

NF-κB regulation: the nuclear response

(2009) Arun K. Mankan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of nuclear glutathione as a key regulator of cell proliferation

(2009) Federico V. Pallardó et al.   MOLECULAR ASPECTS OF MEDICINE

Loss of ATM Impairs Proliferation of Neural Stem Cells Through Oxidative Stress-Mediated p38 MAPK Signaling

(2009) Jeesun Kim et al.   STEM CELLS

Oxidative Stress and Oxidative Damage in Carcinogenesis

(2009) James E. Klaunig et al.   TOXICOLOGIC PATHOLOGY

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

AKT and Oxidative Stress Team Up to Kill Cancer Cells

(2008) Ignacio Dolado et al.   CANCER CELL

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin-induced liver failure

(2008) Jan Heinrichsdorff et al.   EMBO REPORTS

p38 and c-Jun N-Terminal Kinase Mitogen-Activated Protein Kinase Signaling Pathways Play Distinct Roles in the Response of Organogenesis-Stage Embryos to a Teratogen

(2008) J. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

c-Src-p38 Mitogen-Activated Protein Kinase Signaling Is Required for Akt Activation in Response to Ionizing Radiation

(2008) M.-J. Kim et al.   MOLECULAR CANCER RESEARCH

NF-κB signaling, liver disease and hepatoprotective agents

(2008) B Sun et al.   ONCOGENE

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE