Journal
FREE RADICAL RESEARCH
Volume 46, Issue 5, Pages 665-673Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2012.668186
Keywords
anti-leishmanial; antimony resistance; leishmaniasis; nitric oxide; oxidative stress; promastigotes
Categories
Funding
- Department of Science & Technology (DST)
- Council for Scientific and Industrial Research (CSIR), Govt. of India
- Indian Council of Medical Research
- University Grants Commission, Govt. of India
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The survival of Leishmania parasites within macrophages is influenced by generation of free radicals. To establish whether generation of free radicals influenced chemotherapeutic response, promastigotes from isolates causing self-healing or delayed/non-self-healing cutaneous leishmaniasis (CL) or visceral leishmaniasis (VL) were evaluated for their susceptibility to nitric oxide (NO), antimony and miltefosine. In a self-healing CL strain of Leishmania major (5ASKH), susceptibility to NO and antimony was higher than other species. Likewise, a Leishmania amazonensis strain, M2269, showed greater susceptibility to NO and antimony than other species but no such correlation was observed with miltefosine. Additionally, 5ASKH and M2269 showed poorer free radical scavenging capacity as also their thiol levels were lower than species causing VL. Collectively, our study suggests that self-healing isolates tend to be more susceptible to oxidative stress.
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