Journal
FREE RADICAL RESEARCH
Volume 45, Issue 4, Pages 477-482Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2010.549485
Keywords
Breast cancer; free radicals; M(1)dG; fine-needle aspirate; tumour grade; pathological diameter
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Funding
- 'Associazione Italiana per la Ricerca sul Cancro', Milan, Italy
- NIEHS [P42ES017198]
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This study has analysed the generation of 3-(2-deoxy-beta-D-erythro-pentafuranosyl)pyrimido[1,2-a]purin-10(3H)-one deoxyguanosine adduct [M(1)dG], a biomarker of oxidative stress and lipid peroxidation, in breast fine-needle aspirate samples of 22 patients with breast cancer, at different clinical stages, in respect to 13 controls. The multivariate analysis show that M(1)dG adduct was higher in cases than in controls (Mean Ratio (MR) = 5.26, 95% CI = 3.16-8.77). Increased M(1)dG was observed in women with a tumour grade 3 and a pathological diameter 2 (MR = 7.61, 95% CI = 3.91-14.80 and MR = 5.75, 95% CI = 3.13-10.59, respectively). A trend with increasing tumour grade and pathological diameter was present (MR = 1.98, 95% CI = 1.57-2.50 and MR = 2.44, 95% CI = 1.71-3.48, respectively). Not significant effects of age and smoking habit were found (MR = 1.58, 95% CI = 0.92-2.72 and MR = 1.68, 95% CI 0.88-3.20, respectively). An increment over the background frequency of M(1)dG can contribute to breast cancer development. Increasing severity of breast tumour can influence DNA damage level.
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