Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Qian Wang, Coert J. Zuurbier, Ragnar Huhn, Carolin Torregroza, Markus W. Hollmann, Benedikt Preckel, Charissa E. van den Brom, Nina C. Weber
Summary: Pharmacological conditioning aims to protect the heart from myocardial ischemia-reperfusion injury. This review updates the recent developments in pharmacological conditioning and summarizes the clinical evidence of these strategies in the perioperative setting. It discusses the cellular processes during ischemia and reperfusion that contribute to acute injury and explores promising interventions targeting these processes.
Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Eman Gouda, Fawzi Babiker
Summary: This study investigated the antioxidant and anti-inflammatory effects of Gum Arabic in protecting the heart against ischemia/reperfusion injury. The results showed that GA significantly reduced infarct size and cardiac enzyme levels, and decreased pro-inflammatory cytokine levels.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Blaze M. Pharoah, Vinayak S. Khodade, Alexander Eremiev, Eric Bao, Ting Liu, Brian O'Rourke, Nazareno Paolocci, John P. Toscano
Summary: Hydrogen sulfide (H2S) has protective effects in cardiovascular disease, but its mechanism of action is still unclear. Recent studies have found that H2S can modulate protein activity through redox-based post-translational modifications. Other reactive sulfur species also exhibit cardioprotective action. Exogenous hydropersulfide donation is a superior approach compared to other reactive sulfur species and mechanical post-conditioning in protecting cardiac function and limiting infarct size.
Review
Biochemistry & Molecular Biology
Sebastian Roth, Carolin Torregroza, Katharina Feige, Benedikt Preckel, Markus W. Hollmann, Nina C. Weber, Ragnar Huhn
Summary: Pharmacological conditioning aims to protect the heart from myocardial I/R injury, but there remains a gap between basic research and clinical practice. This review covers new developments in experimental research and clinical evidence, highlighting the challenges of applying pharmacological conditioning in a clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Yushi Wu, Haiqiong Liu, Xianbao Wang
Summary: Acute myocardial infarction requires timely reperfusion to reduce myocardial damage, but reperfusion may lead to myocardial ischemia/reperfusion injury. Pharmacological postconditioning is an effective and flexible strategy to reduce myocardial injury by administering medication before or during early reperfusion.
Article
Biochemistry & Molecular Biology
Rolf Schreckenberg, Annemarie Wolf, Tamara Szabados, Kamilla Gomori, Istvan Adorjan Szabo, Gergely Agoston, Gabor Brenner, Peter Bencsik, Peter Ferdinandy, Rainer Schulz, Klaus-Dieter Schlueter
Summary: Hypoxia upregulates PCSK9 in the heart, which affects myocyte function. Genetic deletion of PCSK9 or antagonism of circulating PCSK9 reduces reperfusion injury. A high-fat diet decreases survival rate during reperfusion, likely due to increased MMP9 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Magda C. Diaz-Vesga, Ursula Zuniga-Cuevas, Andres Ramirez-Reyes, Nicolas Herrera-Zelada, Ivan Palomo, Roberto Bravo-Sagua, Jaime A. Riquelme
Summary: Despite advances in treating myocardial infarction, limiting infarct size after reperfusion to prevent heart failure remains a challenge, with factors such as comorbidities and experimental models needing to be considered for effective cardioprotection studies. Studies show that current therapeutic strategies may not fully protect the aging heart from myocardial infarction, prompting the need for potential new cardioprotective strategies targeting the aging heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alice E. Zemljic-Harpf, Louise E. See Hoe, Jan M. Schilling, Juan P. Zuniga-Hertz, Alexander Nguyen, Yash J. Vaishnav, Gianna J. Belza, Boris P. Budiono, Piyush M. Patel, Brian P. Head, Wolfgang H. Dillmann, Sushil K. Mahata, Jason N. Peart, David M. Roth, John P. Headrick, Hemal H. Patel
Summary: The study demonstrates that morphine treatment can improve cardiac function and structure, enhance tolerance to ischemia-reperfusion injury, and potentially have translational value in diabetic patients.
Article
Immunology
Yunong Li, Jiaolin Zheng, Yanmei Zhu, Youyang Qu, Rui Suo, Yulan Zhu
Summary: Methylcobalamin demonstrates neuroprotective effects on cerebral ischemic injury by increasing cell viability and autophagy, reducing inflammation and apoptosis, and activating the ERK1/2 pathway. Its potential as a novel neuroprotective therapy for ischemic stroke is promising.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ji-Won Hwang, Jae-Hyun Park, Bong-Woo Park, Hyeok Kim, Jin-Ju Kim, Woo-Sup Sim, Natalia P. Mishchenko, Sergey A. Fedoreyev, Elena A. Vasileva, Kiwon Ban, Hun-Jun Park, Sang-Hong Baek
Summary: Histochrome (HC), with potent antioxidant and iron-chelating capacity, is shown to improve cardiac function and reduce cardiac fibrosis in myocardial I/R injury by decreasing intracellular and mitochondrial ROS levels, preventing ferroptotic cell death. Early intervention with HC before reperfusion is a promising therapeutic option for secondary cardioprotection in patients who undergo coronary reperfusion therapy.
Article
Medicine, Research & Experimental
Juma El-Awaisi, Dean P. J. Kavanagh, Marco R. Rink, Chris J. Weston, Nigel E. Drury, Neena Kalia
Summary: Elderly patients have a poorer prognosis after MI, possibly due to increased susceptibility of coronary microvessels to injury. The IL-36/IL-36R pathway may play a crucial role in this process. Targeting this pathway in elderly hearts could be a potential therapy for MI.
Article
Cell Biology
Ke Peng, Hong Liu, Bin Yan, Xiao-Wen Meng, Shao-Yong Song, Fu-Hai Ji, Zhengyuan Xia
Summary: This study identified and validated key candidate genes related to inflammation and apoptosis pathways underlying myocardial I/R injury. Inhibition of Cathepsin S was shown to alleviate myocardial I/R-induced injury by suppressing inflammation and apoptosis, potentially offering clinical applications in cardioprotection.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryota Murase, Yasushige Shingu, Satoru Wakasa
Summary: This study demonstrates that pretreatment with chloroquine attenuates ischemic and reperfusion injury in rat hearts by activating the ERK1/2 pathway and provides cardioprotective effects.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Chemistry, Analytical
Linrui Duan, Hua Li, Jiani Yuan, Hang Zhao, Xiaokai Zhang, Xuanxuan Zhou, Qian Yang, Wei Cao, Yanhua Xie, Shan Miao, Siwang Wang
ANALYTICAL METHODS
(2015)
Article
Biochemistry & Molecular Biology
Di Zhang, Hua Li, Jian-Bo Wang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2015)
Article
Biochemistry & Molecular Biology
Ying Chen, Zhuying Liu, Fuxing Zhou, Hang Zhao, Qian Yang, Hua Li, Jiyuan Sun, Siwang Wang
BIOMOLECULES & THERAPEUTICS
(2016)
Article
Medicine, Research & Experimental
Fan Song, Fei Hua, Hua Li, Xuanxuan Zhou, Li Yan, Qian Yang, Yanhua Xie, Weixun Duan, Siwang Wang, Jiyuan Sun
Article
Multidisciplinary Sciences
Hua Li, Fan Song, Lin-Rui Duan, Juan-Juan Sheng, Yan-Hua Xie, Qian Yang, Ying Chen, Qian-Qian Dong, Bang-Le Zhang, Si-Wang Wang
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Ya Zhang, Hang Zhao, Hua Li, Wei Cao, Fang Wang, Tian Zhang, Si-Wang Wang
Article
Cell Biology
Di Zhang, Chengtao Lu, Zhe Yu, Xiayin Wang, Li Yan, Juanli Zhang, Hua Li, Jianbo Wang, Aidong Wen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Medicine, Research & Experimental
Li Yan, Fan Song, Hua Li, Yao Li, Jie Li, Qiao-Yan He, Di Zhang, Fang Wang, Meng Zhang, Hang Zhao, Tian Feng, Ying-Yong Zhao, Si-Wang Wang
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Chemistry, Analytical
Ya Zhang, Meng Zhang, Hua Li, Hang Zhao, Fang Wang, Qiaoyan He, Tian Zhang, Siwang Wang
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2018)
Article
Pharmacology & Pharmacy
Zhe Yu, Fan Song, Yu-Chen Jin, Wei-Min Zhang, Ya Zhang, En-Jun Liu, Dan Zhou, Lin-Lin Bi, Qian Yang, Hua Li, Bang-Le Zhang, Si-Wang Wang
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Integrative & Complementary Medicine
Yao Li, Qian Yang, Zhi-hui Shi, Min Zhou, Li Yan, Hua Li, Yan-hua Xie, Si-wang Wang
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Biology
Shan Zhang, Yang Liu, Yunyang Lu, Hua Li, Yuqiang Ji, Fei Fang, Haifeng Tang, Pengcheng Qiu
Article
Medicine, Research & Experimental
Dan Zhou, Qian Yang, Tian Tian, Ying Chang, Yao Li, Lin-Rui Duan, Hua Li, Si-Wang Wang
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Oncology
Peng-Cheng Qiu, Yun-Yang Lu, Shan Zhang, Hua Li, Han Bao, Yu-Qiang Ji, Fei Fang, Hai-Feng Tang, Guang Cheng
Article
Pharmacology & Pharmacy
Dan Zhou, Qian Yang, Zhe Yu, Ying Chang, Tian Tian, Zhi-Hui Shi, Hong-Liang Dong, Hua Li, Jun Guo, Si-Wang Wang
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2019)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)