Article
Agronomy
Sorin Ciulca, Gheorghe Roma, Ersilia Alexa, Isidora Radulov, Ileana Cocan, Emilian Madosa, Adriana Ciulca
Summary: This study evaluated the total polyphenol content and antioxidant activity of fruits in six wild bilberry populations from Romania over three years. Results showed significant differences in polyphenol content and antioxidant activity between populations from different regions and across years, indicating the impact of environmental conditions on the accumulation of polyphenols in bilberry fruits.
Article
Materials Science, Multidisciplinary
Citlali Alejandra Marin-Flores, Odin Rodriguez-Nava, Margarita Garcia-Hernandez, Rosario Ruiz-Guerrero, Fernando Juarez-Lopez, Angel de Jesus Morales-Ramirez
Summary: ZnO particles were synthesized and their free radical scavenging activity properties were evaluated in this study. The results showed that the scavenging activity increased with smaller particle size and lower ZnO dosage. A pseudo-first-order kinetics model may be present in the reaction.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Engineering, Biomedical
Gyeong Min Lee, Se-jeong Kim, Eun Mi Kim, Eunhyung Kim, Sangmin Lee, Eunjin Lee, Hee Ho Park, Heungsoo Shin
Summary: A composite hydrogel incorporating epigallocatechin-gallate (EGCG)-coated nanofiber particles (EF) was developed. Compared to traditional GelMA hydrogel, this composite hydrogel showed significant improvements in cell viability, intracellular oxidative stress, and cell spreading and migration ability.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Ceramics
Zhaojun Qi, Sen Wang, Yan Li, Lifeng Wang, Lin Zhao, Qiang Ge, Jin Zhong Zhang
Summary: The novel free radical scavenger ML-Ti3C2Tx MXene exhibits high scavenging efficiency due to its intrinsic reducing property, rather than hydrogen donation ability from surface functional groups. The observed scavenging activity is attributed to the reducing property of ML-Ti3C2Tx, as compared to other materials.
CERAMICS INTERNATIONAL
(2021)
Article
Nanoscience & Nanotechnology
Daehong Ha, Joo Hyung Lee, Hyeri Jeon, Yoo Jin Kang, Junmo Jeon, Tae Hoon Lee, Seungwoo Hong, Young-Kwan Kim, Kyungtae Kang
Summary: The study demonstrated the importance of functional amyloid fibers in melanogenesis and their relationship with the intrinsic spin characters of melanin. It showed that adding an amyloid scaffold greatly increased the spin density in synthetic melanin and resulted in various alterations in its properties. This work provides insights into the role of functional amyloid in melanogenesis and the superiority of natural melanin over synthetic variants in terms of spin-related properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Haitao Yuan, Fujing Wang, Zhen Wang, Di Gu, Wei Huang, Chunjin Fu, Xiaoxian Wang, Jingbo Ma, Zhijie Li, Lingyun Dai, Xinzhou Zhang, Wei Xiao, Jigang Wang
Summary: In this study, a metal-phenolic nanozyme named RosA-Mn NPs was designed with broad spectrum antioxidant functionalities. The nanozyme promotes the recovery of mitochondrial function, reduces endoplasmic reticulum stress and secondary inflammation, and mitigates kidney damage through renal tubular targeting. In addition, RosA-Mn NPs also protect the kidney from oxidation and inflammation in an animal model.
ACS MATERIALS LETTERS
(2023)
Article
Energy & Fuels
Kewen Peng, Shouceng Tian, Yiqun Zhang, Wanjun Qu, Qianxi Wang
Summary: This study examines the behavior of radicals in the scavenging process and quantifies the scavenging efficiency of terephthalate in the high-power ultrasound oxidation process. It is found that the small mass diffusivity of terephthalate limits its scavenging efficiency, resulting in a maximum radical trapping efficiency below 30%.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2023)
Article
Biochemistry & Molecular Biology
Uyory Choe, Jianghao Sun, Elena Bailoni, Pei Chen, Yanfang Li, Boyan Gao, Thomas T. Y. Wang, Jiajia Rao, Liangli (Lucy) Yu
Summary: The study investigated the chemical composition, total phenolic content, and potential health benefits of tomato seed flour, including antioxidant, anti-inflammatory, and gut microbiota modulation properties. Tomato seed flour extracts dose-dependently suppressed the expression of pro-inflammatory markers and altered bacterial phyla and genera. The findings support the use of tomato seed flour as a value-added food ingredient.
Article
Food Science & Technology
Chun-Min Ma, Jun-Ren Zhao, Fei-Fei Wu, Qiang Zhang, Xin-Huai Zhao
Summary: This study investigated the non-covalent interactions involved in the formation of caseinate-flavonol complexes, revealing that the chemical structures and hydroxyl group numbers of flavonols play a critical role in the interactions with casein and the radical scavenging activities of the resultant complexes.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2022)
Article
Biochemistry & Molecular Biology
Mohan Chen, Zheng Li, Shuang Jin, Chi Zhang, Ling Liu, Ling Zhang, Hongli Liu, Yunsheng Xue
Summary: The free radical scavenging potency and mechanisms of seven natural coumestans were evaluated using density functional theory. The results showed that these compounds prefer formal hydrogen atom transfer mechanism in non-polar environment and gas phase, while sequential proton loss electron transfer mechanism is favored in polar media. Sequential double proton loss double electron transfer mechanism represents the preferred pathway in aqueous solution at physiological pH. The essential role of ortho-dihydroxyl group, noncovalent interaction, and solvents on radical-trapping potency was highlighted.
Article
Biochemistry & Molecular Biology
Purabi Sarkar, Christy Lite, Praveen Kumar, Mukesh Pasupuleti, N. T. Saraswathi, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Aziz Arshad, Jesu Arockiaraj
Summary: The study identified the antioxidant role of sulfite reductase derived from Arthrospira platensis through the short peptide TL15, which showed strong antioxidant activity without toxicity in human leukocytes. In zebrafish larvae, TL15 peptide reduced H2O2-induced ROS levels and enhanced antioxidant enzyme activity. Overall, TL15 acts as a potential antioxidant with dose-specific properties, making it promising for biopharmaceutical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Wei Zheng, XuPing Li, Glib V. Baryshnikov, Xueru Shan, Farhan Siddique, Cheng Qian, Shengyin Zhao, Hongwei Wu
Summary: This study presents a rational design strategy to protect photoinduced carbonyl free radical emission through electrostatic interaction and spin delocalization effects. A host-guest system consisting of tricarbonyl-substituted benzene molecules and imidazolium ionic liquids was constructed, enabling in situ generation and stabilization of carbonyl anion radical emission. The luminescence efficiency was significantly influenced by the anion species and alkyl chain length, with the highest radical emission efficiency being four times higher than a polymer-protected radical system. Theoretical calculations confirmed the synergistic effect of electrostatic interactions and spin delocalization in stabilizing the radical emission.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Tharsius Raja William Raja, Veeramuthu Duraipandiyan, Savarimuthu Ignacimuthu, Udaiyappan Janakiraman, Soosaimanickam Maria Packiam
Summary: Alzheimer's Disease (AD) is a neurodegenerative disorder in the aged population, and polyphenols from various plant sources have been found to have antioxidant and anti-inflammatory properties, making them potential candidates for AD treatment. These polyphenols can protect neurons against oxidative stress and deposition of harmful proteins, thus inhibiting the progression of the disease. In this review, various polyphenols such as hesperidin, resveratrol, and curcumin are highlighted for their neuroprotective effects and potential as therapeutic agents for AD.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Mahesha M. Poojary, Michael Hellwig, Thomas Henle, Marianne N. Lund
Summary: Protein-polyphenol interactions have significant effects on the structure and function of food. This study focuses on the synthesis and characterization of caffeic acid-cysteine (CA-Cys) and chlorogenic acid-cysteine (CGA-Cys) adducts, and develops a quantitative method to detect these adducts in food and beverages. Results show the covalent bonding between milk proteins and CA/CGA, as well as the presence of these adducts in coffee-containing beverages.
Article
Chemistry, Applied
Zheng Hua, Xuedi Zhang, Xue Zhao, Bei-Wei Zhu, Donghong Liu, Mingqian Tan
Summary: In this study, liver-targeted nanocarriers were designed and prepared to efficiently deliver AST by modifying it with lactobionic acid. The results showed that the lactobionic acid-modified AST nanoparticles had significant cellular uptake, and displayed excellent antioxidant properties in preventing mitochondrial depolarization. Moreover, these modified nanoparticles accumulated in the liver due to specific binding with lactobionic acid receptors, suggesting their potential use in developing functional food for liver disease nutrition intervention.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
