Review
Biochemistry & Molecular Biology
Sameera Kumar, Daret St Clair
Summary: Prostate cancer is common in men, and oxidative stress caused by free radicals and reactive oxygen species could be a contributing factor. The superoxide dismutase family plays a crucial role in removing oxygen-derived reactive oxygen species, and increased superoxide dismutase activity may have a protective effect against prostate cancer. Understanding the role of superoxide dismutase in radioresistance has led to the development of interventions targeting the NF-kappa B pathway for prostate cancer treatment.
Article
Chemistry, Medicinal
Bini Mathew, Pedro Ruiz, Shilpa Dutta, Jordan T. Entrekin, Sixue Zhang, Kaval D. Patel, Micah S. Simmons, Corinne E. Augelli-Szafran, Rita M. Cowell, Mark J. Suto
Summary: ALS is a rare neurodegenerative disease with unknown cause, characterized by the gradual degeneration of motor neurons. Mutations in SOD1 and SOD2 genes are associated with ALS. Research has shown that hybrid compounds of SRI-22819 and Ataluren may have improved therapeutic effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Stephen T. Sonis
Summary: Toxicities associated with radiation therapy can be effectively mitigated through interventions aimed at disrupting the biological cascade of toxicity development, with oxidative stress being a key initiator of normal tissue injury. Attempts to supplement endogenous superoxide dismutases or develop synthetic dismutase mimetics have shown some potential, with avasopasem manganese emerging as a promising dismutase mimetic in clinical trials for reducing severe oral mucositis in head and neck cancer patients undergoing chemoradiation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Joo-Eun Kim, Hyun-Wook Lee, Won-Jin Kwak
Summary: In this study, 4-carboxy-TEMPO was selected as a representative SODm, and its ability to effectively promote the disproportionation reaction and accelerate the generation of singlet oxygen was chemically verified. It was found that the release of singlet oxygen evolved by the SODm was decreased when using a quencher. This study provides important reference for the development of additives for practical application of LOBs.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Sandra Yu, Francesco Caruso, Stuart Belli, Miriam Rossi
Summary: This study evaluates the biological role of isoflavones, including formononetin (FMNT), in antioxidant and superoxide reduction activity, as well as their potential PPAR gamma agonist activity. The findings provide insights for further research on the therapeutic potential of natural products in diabetes treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Carina Jaekel, Simon Thelen, Lisa Oezel, Marie H. Wohltmann, Julia Wille, Joachim Windolf, Vera Grotheer
Summary: Dupuytren's disease is a fibroproliferative disorder characterized by myofibroblast generation and higher ROS levels, which can be inhibited by blue light irradiation. The beneficial effect is mediated by significant inhibition of catalase protein expression, highlighting the importance of intracellular ROS homeostasis in DD therapy.
Article
Chemistry, Multidisciplinary
Ruomei Li, Zhiyu Zhu, Bolin Zhang, Ting Jiang, Cheng Zhu, Peng Mei, Yu Jin, Ruiqing Wang, Yixin Li, Weiming Guo, Chengxiao Liu, Lunguo Xia, Bing Fang
Summary: Manganese doping is used to enhance bone regeneration by regulating adaptive immunity. It leads to increased recruitment of CD4+ T cells and promotes Th2 cell polarization while inhibiting Th1 cell polarization. This immune environment facilitates the osteogenic ability of bone marrow stromal cells and achieves consequential regeneration of mandibular bone defect.
Review
Cell Biology
Xinyue Chen, Qi Cai, Ruikai Liang, Deju Zhang, Xiao Liu, Meiying Zhang, Yan Xiong, Minxuan Xu, Qi Liu, Pengyang Li, Peng Yu, Ao Shi
Summary: Copper is a vital mineral for normal physiological processes, including cardiovascular systems. However, copper-induced cell death has been recognized as an important factor in the pathogenesis and progression of cardiovascular disease. Understanding the mechanisms of copper-induced cell death can help improve cardiovascular disease management. This review explores the relationship between copper homeostasis and pathways related to copper-induced cell death in cardiovascular disease, as well as therapeutic strategies.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Multidisciplinary
M. Dolores Garrido, Jamal El Haskouri, Maria D. Marcos, Francisco Perez-Pla, Jose Vicente Ros-Lis, Pedro Amoros
Summary: This study reports the preparation of a novel nanocomposite with enzyme-like activity for decomposing reactive oxygen species (ROS). The nanocomposite, consisting of MnOx needles covered with SiO2 porous material, was synthesized using a two-step procedure. The material was characterized, and its bimodal porosity and efficient enzyme activities were observed. The study also proposed reaction mechanisms and demonstrated the role of silica in catalase activity.
Review
Biochemistry & Molecular Biology
Xu Zhang, Depei Zhang, Li Xiang, Qiying Wang
Summary: Manganese superoxide dismutase exhibits rapid product inhibition at high temperatures but is less inhibited at lower temperatures. The temperature-dependent kinetics can be explained by changes in coordination of manganese superoxide dismutase. Cold activation of the enzyme is an adaptive response to low temperatures and plays a role in cold stress signaling and physiological responses.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Visarut Buranasudja, Dolly Rani, Ashwini Malla, Khwanlada Kobtrakul, Sornkanok Vimolmangkang
Summary: Formation of oxidative stress in dermal fibroblasts is crucial for skin aging, and using phytochemicals to enhance the cells' ability to combat oxidative stress is a promising strategy to prevent skin aging. Callus culture of Centella asiatica produces unique antioxidant compounds that exhibit anti-skin-aging activities, including upregulation of cellular antioxidant enzymes and inhibition of matrix metalloprotease-9 induction. This highlights the potential of C. asiatica callus extract as an effective anti-skin-aging agent in cosmeceutical preparations.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Debora Coimbra-Costa, Fernando Garzon, Norma Alva, Tiago C. C. Pinto, Fernando Aguado, Joan Ramon Torrella, Teresa Carbonell, Ramon Rama
Summary: Intermittent hypobaric hypoxia (IHH) exerted neuroprotection against acute severe hypoxia (ASH)-induced oxidative injury by preventing oxidative stress, inhibiting the apoptotic cascade, and modulating NF-kappa B and EPO levels in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Debbie S. Retnoningrum, Hiromi Yoshida, Ismiana Pajatiwi, Rahmat Muliadi, Ratna A. Utami, Anita Artarini, Wangsa T. Ismaya
Summary: The manganese superoxide dismutase from Staphylococcus equorum (MnSODSeq) has shown robust activity under various conditions. Strengthening the interactions between the monomers is crucial for improving the enzyme stability. A new strategy using K38R-A121E/Y double substitutions has been proposed, resulting in mutants with similar enzyme activity and enhanced thermal stability. The structure of the L169W mutant was also elucidated, revealing the impact of intramolecular modification on enzyme stability.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Suhuan Zhang, Jitao Lv, Ruixia Han, Zhe Wang, Peter Christie, Shuzhen Zhang
Summary: This study demonstrates that various MnO2 polymorphs can sustainably produce superoxide radicals in the dark, mainly through a one-electron transfer mechanism. These superoxide radicals make significant contributions to the transformation of contaminants by MnO2.
Article
Oncology
Merce Juliachs, Mireia Pujals, Chiara Bellio, Nathalie Meo-Evoli, Juan M. Duran, Esther Zamora, Mireia Pares, Anna Sunol, Olga Mendez, Alex Sanchez-Pla, Francesc Canals, Cristina Saura, Josep Villanueva
Summary: This study aims to find circulating biomarkers for monitoring the response to cancer therapy. The research found that the release of SOD2 protein during chemotherapy treatment is associated with tumor cell death, and the increase in its circulating levels correlates with treatment response, which can be used for non-invasive monitoring of breast cancer patients.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)