Review
Biochemistry & Molecular Biology
Tetsuro Ishii, Eiji Warabi, Giovanni E. Mann
Summary: H2O2 activates Nrf2 through various pathways to regulate gene expression involved in glutathione synthesis and oxidative damage defense. The activation involves neutral sphingomyelinase 2 and ceramide as key factors.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Mustapha Irnaten, Aisling Duff, Abbot Clark, Colm O'Brien
Summary: This study identified abnormalities in multiple calcium signaling pathways (PKC alpha, MAPK, PI3K) in glaucoma LC cells, which may have significant implications for optic nerve head fibrosis and cupping in glaucoma.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Xinmei Yang, Xijun Wu, Xiaosen Wu, Lei Huang, Jingrui Song, Chunmao Yuan, Zhixu He, Yanmei Li
Summary: MQ-16 shows significant inhibitory effects on the proliferation of K562 cells and induces cell cycle arrest at the G2/M phase in a time- and concentration-dependent manner. It induces mitochondria-dependent apoptosis by downregulating anti-apoptotic proteins Bcl-2 and Bcl-xL, and causes time- and concentration-dependent DNA fragmentation. Furthermore, MQ-16 affects the expression of PI3K/Akt/mTOR, JAK2/STAT3, and MAPK pathway-related proteins.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ruolan Tan, Xiaoxuan Hu, Xinyi Wang, Meiqi Sun, Zhenlu Cai, Zixuan Zhang, Yali Fu, Xinlin Chen, Jing An, Haixia Lu
Summary: This study investigates the role of leptin in the biological properties of neural stem cells (NSCs). The findings suggest that leptin promotes the proliferation and neuronal differentiation of NSCs, potentially providing a promising approach for brain repair in neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Muhammed Mehdi Uremis, Nuray Uremis, Emir Tosun, Merve Durhan, Yilmaz Cigremis, Ahmet Baysar, Yusuf Turkoz
Summary: CuD exhibits antiproliferative and cytotoxic effects against HepG2 cells in a dose and time-dependent manner. CuD induces apoptosis and blocks the cell cycle in HepG2 cells, possibly through down-regulation of genes and proteins involved in PI3K/AKT/mTOR, MAPK, and JAK2/STAT3 cascades to activate the apoptotic pathway.
CURRENT CANCER DRUG TARGETS
(2022)
Article
Oncology
Weina Ma, Yanhong Liu, Panpan Lei, Man Zhu, Xiaoyan Pan
Summary: This study found that ND-17 has inhibitory effects on T-ALL cell proliferation and can achieve this through interactions with JAK2. ND-17 also has a significant impact on blocking the S phase of the cell cycle and can suppress signaling pathways such as JAK/STAT, PI3K/AKT/mTOR, and MAPK/ERK1/2.
CURRENT CANCER DRUG TARGETS
(2022)
Article
Biochemistry & Molecular Biology
Hrvoje Mihalj, Josip Butkovic, Stana Tokic, Mario Stefanic, Tomislav Kizivat, Maro Bujak, Mirela Baus Loncar, Martina Mihalj
Summary: Chronic rhinosinusitis (CRS) is a common inflammatory disease affecting the nasal cavity and paranasal sinuses, often accompanied by nasal polyps. This study investigated the expression patterns of antioxidative enzymes and immune defense factors in the nasal mucosa and polyps of CRSwNP patients. The results showed differential gene expression in different tissues and correlation with disease severity. Surgical and corticosteroid treatment improved the appearance of the sinuses but had varying effects on gene expression patterns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Mohamed F. Balaha, Ahmed A. Alamer, Alaa A. Eisa, Hashim M. Aljohani
Summary: In this study, it was shown that shikonin can alleviate gentamicin-induced kidney injury while preserving its bactericidal effect. Shikonin restored normal kidney function and histological architecture, as well as renal endocytic function. These effects may be attributed to the modulation of the renal antioxidant system and suppression of renal inflammation and apoptosis.
Article
Pharmacology & Pharmacy
Lina Chen, Yuan Guo, Shuiqing Qu, Kai Li, Ting Yang, Yuanmin Yang, Zhongyuan Zheng, Hui Liu, Xi Wang, Shuoqiu Deng, Yu Zhang, Xiaoxin Zhu, Yujie Li
Summary: Shengmai formula (SMF) can attenuate myocardial injury induced by UFPM + MI by modulating oxidative stress and related signaling pathways. This traditional Chinese medicine exhibits protective effects on myocardial function and histopathology.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jiangpeng Jing, Mingzhu Yan, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Qiang Meng
Summary: The study revealed that cirsilineol inhibited the growth of C6 cells and induced apoptosis by inhibiting the PI3K/Akt/mTOR and MAPK signaling pathways. This suggests that cirsilineol may be a potential candidate for the treatment of glioma in the future.
APPLIED NANOSCIENCE
(2022)
Article
Neurosciences
Mayuko Sugimoto, Risa Ko, Hiromi Goshima, Atsushi Koike, Makio Shibano, Ko Fujimori
Summary: Formononetin protects against H2O2-induced neuroblastoma cell death by reducing ROS levels and enhancing antioxidant gene expression through the activation of the PI3K/Akt-Nrf2 signaling pathway. Additionally, formononetin suppresses apoptosis by inhibiting MAPK phosphorylation in SH-SY5Y cells, suggesting its potential as a therapeutic agent for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Wen-Ping Jiang, Jeng-Shyan Deng, Shyh-Shyun Huang, Sheng-Hua Wu, Chin-Chu Chen, Jung-Chun Liao, Hung-Yi Chen, Hui-Yi Lin, Guan-Jhong Huang
Summary: Sanghuangporus sanghuang mycelium (SS) demonstrates hepatoprotective effects against paracetamol-induced liver injury by inhibiting oxidative stress and inflammation, thereby protecting liver cells.
Article
Integrative & Complementary Medicine
Xiaolong Mi, Zhijun Zhang, Jinfang Cheng, Zheng Xu, Kaiyi Zhu, Yunxia Ren
Summary: This study found that schisantherin A (SCA), a monomer of dibenzocyclooctadiene lignan found in Schisandra chinensis fruits, can protect the heart from ischemia-reperfusion injury by activating the PI3K-AKT/Nrf2/ARE pathway and suppressing the TLR4/MAPK/NF-κB pathways, and reducing the severity of myocardial infarction.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Endocrinology & Metabolism
Mingzheng Liu, Fan He, Mengci Shao, Tianyuan Li, Liecheng Wang, Yuanyin Wang, Wenhua Xu
Summary: This study found that pituitary adenylate cyclase-activating polypeptide (PACAP) can regulate the activity of voltage-gated sodium channels (Nav1.7) through the mitogen-activated protein kinase/ ERK kinase (MEK/ERK) pathway in the trigeminal ganglion, thereby alleviating trigeminal neuralgia. The results of this study indicate that PACAP inhibition can relieve mechanical pain hypersensitivity in rats with trigeminal neuralgia.
Review
Clinical Neurology
Omid Razi, Bakhtyar Tartibian, Ana Maria Teixeira, Nastaran Zamani, Karuppasamy Govindasamy, Katsuhiko Suzuki, Ismail Laher, Hassane Zouhal
Summary: This article reviews the issue of thermoregulation in patients with multiple sclerosis and discusses potential situations they may encounter when infected with SARS-CoV-2. It also summarizes the role of thermoregulation and its relationship with regular physical exercise.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Multidisciplinary Sciences
Saskia F. Erttmann, Nelson O. Gekara
NATURE COMMUNICATIONS
(2019)
Article
Infectious Diseases
Trung T. Trinh, Karoline Assig, Quyen T. L. Tran, Andre Goehler, Linh N. H. Bui, Claudia Wiede, Bettina Folli, Sabine Lichtenegger, Tinh T. Nguyen, Gabriel E. Wagner, Christian Kohler, Ivo Steinmetz
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Public, Environmental & Occupational Health
Eva Leitner, Elisabeth Schreiner, Maria Neuhold, Michael Bozic, Christian Pux, Gerald Pichler, Walter Schippinger, Ivo Steinmetz, Robert Krause, Ines Zollner-Schwetz
AMERICAN JOURNAL OF INFECTION CONTROL
(2020)
Article
Infectious Diseases
L-M Matzkies, E. Leitner, E. Stelzl, K. Assig, M. Bozic, D. Siebenhofer, M. E. Mustafa, I Steinmetz, H. H. Kessler
CLINICAL MICROBIOLOGY AND INFECTION
(2020)
Article
Infectious Diseases
Stefan Monecke, Elisabeth Koenig, Megan R. Earls, Eva Leitner, Elke Mueller, Gabriel E. Wagner, David M. Poitz, Lutz Jatzwauk, Teodora Vremera, Olivia S. Dorneanu, Alexandra Simbeck, Andreas Ambrosch, Ines Zollner-Schwetz, Robert Krause, Werner Ruppitsch, Wulf Schneider-Brachert, David C. Coleman, Ivo Steinmetz, Ralf Ehricht
Article
Public, Environmental & Occupational Health
P. Brinskelle, E. Koenig, G. Sendlhofer, K. A. Baumhackl, R. Winter, I Sawetz, L. P. Kamolz, I Steinmetz, H. Friedl, D. B. Lumenta
JOURNAL OF HOSPITAL INFECTION
(2020)
Article
Infectious Diseases
Gabriel E. Wagner, Esther Foederl-Hoebenreich, Karoline Assig, Michaela Lipp, Andreas Berner, Christian Kohler, Sabine Lichtenegger, Julia Stiehler, Wisansanee Karoonboonyanan, Nida Thanapattarapairoj, Chidchanok Promkong, Sirikamon Koosakulnirand, Panjaporn Chaichana, Ralf Ehricht, Anne-Marie Gad, Hans H. Soeffing, Susanna J. Dunachie, Narisara Chantratita, Ivo Steinmetz
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Multidisciplinary Sciences
Julia Nilsson, Maria Hornberg, Anja Schmidt-Christensen, Kajsa Linde, Maria Nilsson, Marine Carlus, Saskia F. Erttmann, Sofia Mayans, Dan Holmberg
SCIENTIFIC REPORTS
(2020)
Article
Virology
Gabriel E. Wagner, Massimo G. Totaro, Andre Volland, Michaela Lipp, Sabine Saiger, Sabine Lichtenegger, Patrick Forstner, Dorothee von Laer, Gustav Oberdorfer, Ivo Steinmetz
Summary: Rapid molecular surveillance of SARS-CoV-2 S-protein variants is crucial due to immune escape and increased infectivity. This study developed a user-friendly protocol for high-throughput S-gene sequencing and an automated tool for mutation analysis, offering a simple, rapid, and cost-effective approach compared to whole-genome sequencing. Optimization of primer design and sequencing strategy allowed successful amplification and accurate detection of variants, reducing time and resources required for variant screening.
Article
Immunology
Saskia F. Erttmann, Patrycja Swacha, Kyaw Min Aung, Bjorn Brindefalk, Hui Jiang, Anetta Hartova, Bernt Eric Uhlin, Sun N. Wai, Nelson O. Gekara
Summary: This study revealed the modulation of systemic immunity and response to viral infection by gut commensals. Peripheral cGAS-STING activation plays a crucial role in promoting host resistance to systemic viral infections.
Article
Medicine, General & Internal
Weronika Schary, Filip Paskali, Simone Rentschler, Christoph Ruppert, Gabriel E. Wagner, Ivo Steinmetz, Hans-Peter Deigner, Matthias Kohl
Summary: Point-of-care diagnostics, particularly lateral flow assays, provide a great opportunity for rapid, precise, low-cost, and accessible disease diagnosis. The use of smartphones as biosensors can enhance the portability and affordability of diagnostic devices, making them beneficial for remote areas and low-resource countries.
Article
Medicine, General & Internal
Eva M. Matzhold, Guenther F. Koermoeczi, Chiara Banfi, Marlies Schoenbacher, Camilla Drexler-Helmberg, Ivo Steinmetz, Andrea Berghold, Peter Schlenke, Gabriel E. Wagner, Anja Stoisser, Barbara Kleinhappl, Wolfgang R. Mayr, Thomas Wagner
Summary: Individuals with ABO type O had lower levels of anti-A/anti-B antibodies in their serum after mild COVID-19 compared to healthy controls. However, no significant differences were observed in saliva. This suggests that pre-existing high serum concentrations of anti-A/anti-B antibodies may have a protective effect against SARS-CoV-2 infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Johanna Dabernig-Heinz, Gabriel E. Wagner, Eva Leitner, Werner Ruppitsch, Ivo Steinmetz, Christoph Hoegenauer, Ellen L. Zechner, Sabine Kienesberger
Summary: In this study, the hybrid assembled genome of cytotoxic K. oxytoca strain AHC-6 was reported, which has a size of 5.7 Mbp, a GC content of 55.2%, and 5,258 coding sequences after assembly and annotation. Klebsiella oxytoca is a ubiquitous bacterium that is increasingly associated with inflammatory diseases.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Biochemical Research Methods
Saskia F. Erttmann, Nelson O. Gekara
Summary: This article describes a protocol for enriching bacterial membrane vesicles from serum and colon, which can be adapted for other tissues. The protocol involves pre-clearing serum or colon fluids using 0.2-mm syringe filters, concentrating the vesicles using centrifugal filter devices, isolating the vesicles with qEV size exclusion columns, and concentrating the isolated vesicle fractions for downstream analyses. For more detailed information on the use and execution of this protocol, please refer to Erttmann et al. (2022).
Article
Cell & Tissue Engineering
N. Normann, G. Tietz, A. Kuehn, C. Fuchs, V Balau, K. Schulz, J. Kolata, T. Schuerholz, A. Petersmann, S. Stentzel, L. Steil, S. O. Kuhn, K. Meissner, U. Voelker, M. Nauck, I Steinmetz, D. Raafat, M. Gruendling, B. M. Broeker
EUROPEAN CELLS & MATERIALS
(2020)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)