Article
Biochemistry & Molecular Biology
Witold K. Subczynski, Justyna Widomska
Summary: This study demonstrates a linear relationship between the spin-lattice relaxation rate and rotational diffusion coefficients of lipid spin labels. The results provide a precise description of membrane fluidity and allow for easy comparison with other membrane fluidity data.
Article
Chemistry, Multidisciplinary
Yunfan Qiu, Asif Equbal, Chenjian Lin, Yuheng Huang, Paige J. Brown, Ryan M. Young, Matthew D. Krzyaniak, Michael R. Wasielewski
Summary: Photoexcited organic chromophores combined with stable radicals can be used as candidates for quantum information applications. In this study, the synthesis and characterization of 1,6,7,12-Tetra-(4-tert-butylphenoxy)-perylene-3,4 : 9,10-bis(dicarboximide) (tpPDI) linked to a partially deuterated alpha,gamma-bisdiphenylene-beta-phenylallyl radical (BDPA-d(16)) were performed using time-resolved optical and electron paramagnetic resonance (EPR) spectroscopies. The results showed efficient generation of a quartet state (Q) followed by a spin-polarized doublet ground state (D-0) upon photoexcitation of tpPDI-BDPA-d(16).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Arianna Actis, Michele Melchionna, Giacomo Filippini, Paolo Fornasiero, Maurizio Prato, Enrico Salvadori, Mario Chiesa
Summary: This study assesses the influence of morphology and light-excitation on the number and chemical nature of radical defects in carbon nitride (CN) and derives the spatial distribution of native radicals in CN using magnetic dipole-dipole coupling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Vsevolod I. Borovkov, Victor A. Bagryansky, Yuri N. Molin
Summary: The oxygen molecule in its ground triplet state is a strong electron acceptor. Electron transfer to form a superoxide anion is an important step in many processes, and spin effects play a role in the reaction depending on the relative diffusion coefficient. At low diffusion coefficients, spin effects are insignificant, but at higher diffusion coefficients, electron transfer becomes spin-selective.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
One-Sun Lee, Mohamed E. Madjet, Khaled A. Mahmoud
Summary: The study conducted molecular dynamics simulations to investigate the interaction between MXene nanosheets and a model bacterial membrane, revealing that MXene adsorption could induce a local phase transition in the membrane and lead to cell lysis. This proposed bactericidal mechanism of MXenes provides a useful model for designing new antibacterial nanomaterials.
Article
Food Science & Technology
Chunli Fan, Tingting Feng, Xingwei Wang, Shuqin Xia, Caleb John Swing
Summary: This study evaluated the encapsulation difference and stability mechanism of nanoliposomes loaded with different kinds and loads of liposoluble vitamins. It was found that VD and VE were not suitable for high-load encapsulation, but the stability of other LSV-NLPs was excellent during storage. LSV encapsulation inhibited malon-dialdehyde production, decreased liposome surface roughness, and improved nanoliposome rigidity. The accumulation of acyl chain was enhanced, and the interchain longi-tudinal and intra-chain transverse order degree was increased.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Artem S. Poryvaev, Eva Gjuzi, Daniil M. Polyukhov, Frank Hoffmann, Michael Froba, Matvey V. Fedin
Summary: This study proposes using radical-grafted mesoporous silica as a versatile nanoplatform for spin-based QC/QIP, utilizing stable organic radicals for efficient spin manipulation with long electron spin decoherence time. The mesoporous structure of these composites is nuclear-spin free and allows for embedding guest molecules, promoting robustness and tunability as highly promising nanoplatforms for future QC/QIP developments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Wei-Ling Jiang, Zhiyong Peng, Bin Huang, Xiao-Li Zhao, Di Sun, Xueliang Shi, Hai-Bo Yang
Summary: This study systematically investigated the spin-spin interactions of exo- and endo-TEMPO radical-functionalized metallacycles and metallacages constructed via coordination-driven self-assembly. The results revealed distinct spin-spin interactions in solution and solid states, with a large zero-field splitting observed in certain crystalline forms. Moreover, reversible on-off switching of the zero-field splitting was successfully achieved via crystal-to-amorphous transformation induced by mechanical grinding and solvent vapor stimuli.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Applied
Jacqueline Lux, Mykhailo Azarkh, Laura Fitzner, Julia K. Keppler, Karin Schwarz, Malte Drescher, Anja Steffen-Heins
Summary: SDSL of natural beta-lactoglobulin revealed that different spin labels bind to specific sites to varying extents, affecting the formation of amyloid-like structures. The spatial distribution of labels within protein aggregates was confirmed to be similar to a string of pearls, indicating a potential mechanism for amyloid formation.
FOOD HYDROCOLLOIDS
(2021)
Review
Chemistry, Multidisciplinary
Sergei Chapyshev, Enrique Mendez-Vega, Wolfram Sander
Summary: High-spin nitrenes have the largest magnetic anisotropy among C-, N-, and O-centered polyradicals, making them significant for exploring organic molecular magnetism and quantum information processing. While quintet and septet nitrenes were obtained nearly 50 years ago, experimental and theoretical studies on these reactive species have only recently become feasible due to advancements in molecular spectroscopy and computational chemistry. Dozens of quintet dinitrenes and septet trinitrenes have been successfully characterized using IR, UV/Vis, and EPR spectroscopy, offering valuable insights into their electronic structure, magnetic properties, and reactivity.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Physical
Joshua L. Wort, Swati Arya, Katrin Ackermann, Alan J. Stewart, Bela E. Bode
Summary: Pulse-dipolar EPR is an attractive method for structural characterization in solution, especially when paired with genetically encoded self-assembling spin labels and Cu-II-chelates. The combination of room-temperature isothermal titration calorimetry and cryogenic relaxation-induced dipolar modulation enhancement showed that the double-histidine motif spin labeling with Cu-II-nitrilotriacetic acid is robust against competition from Zn-II-NTA and maintains high nM binding affinity even under acidic and basic conditions. The strategy is well-suited for diverse biological applications, with the requirement of other metal ion cofactors or slightly acidic pH not necessarily being prohibitive.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Miroslava Vosahlikova, Lenka Roubalova, Jana Brejchova, Martin Alda, Petr Svoboda
Summary: This study compared the biophysical parameters and lipid peroxidation levels in membranes isolated from the forebrain cortex of rats treated with therapeutic lithium and/or subjected to sleep deprivation. The results showed that changes in both lithium administration and sleep deprivation affected the properties of rat FBC membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Polymer Science
Nikola Babic, Simon Pondaven, Herve Vezin
Summary: Autoxidation is a common spontaneous oxygen-mediated radical reaction in the degradation processes of hydrocarbon-based materials. In this study, EPR spin-trapping technique was used to investigate radical species involved in the autoxidation of synthetic base oil. The difference in generating radical species between aged and non-aged samples of the same base oil was studied by introducing oxygen and aging the samples at 140 degrees C.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Chemistry, Multidisciplinary
Vega Lloveras, Pilar Elias-Rodriguez, Luca Bursi, Ehsan Shirdel, Alejandro R. Goni, Arrigo Calzolari, Jose Vidal-Gancedo
Summary: This study reports the first demonstration of a surface molecular switch based on gold nanoparticles (AuNPs) decorated with persistent perchlorotriphenylmethyl (PTM) radicals. The redox properties of PTM are exploited to fabricate electrochemical switches with high stability and reversibility. The electronic interaction between the radicals and the gold surface is investigated and confirmed by multiple experimental techniques.
Article
Biochemistry & Molecular Biology
Ekaterina Georgieva, Yanka Karamalakova, Georgi Arabadzhiev, Vasil Atanasov, Rositsa Kostandieva, Mitko Mitev, Vanya Tsoneva, Yovcho Yovchev, Galina Nikolova
Summary: The main factors in COVID-19 pathology are the abnormal generation of free radicals and oxidative stress, which can cause extensive structural changes at the cellular and molecular levels. The concentration of human serum albumin is crucial for maintaining plasma oncotic pressure, nutrient and drug transport, drug therapy effectiveness, and prevention of drug toxicity. Low albumin levels and structural defects in the protein may lead to ineffective therapy, frequent complications, and high mortality rates.
Article
Biochemistry & Molecular Biology
M. Zareba, J. Widomska, J. M. Burke, W. K. Subczynski
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Ophthalmology
Justyna Widomska, Witold K. Subczynski
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Environmental Sciences
Grazyna Olchowik, Justyna Widomska, Marek Tomaszewski, Malgorzata Gospodarek, Monika Tomaszewska, Ewa Jagiello-Wojtowicz
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2014)
Article
Biology
Jerzy Cieniawa, Jacek Baszak, Grazyna Olchowik, Justyna Widomska
COMPUTERS IN BIOLOGY AND MEDICINE
(2013)
Article
Biochemistry & Molecular Biology
Justyna Widomska, Renata Welc, Wieslaw I. Gruszecki
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2019)
Review
Nutrition & Dietetics
Justyna Widomska, Witold K. Subczynski
Review
Nutrition & Dietetics
Justyna Widomska, John Paul SanGiovanni, Witold K. Subczynski
Review
Biochemistry & Molecular Biology
Justyna Widomska, Wieslaw I. Gruszecki, Witold K. Subczynski
Summary: Macular xanthophylls, absorbed from the human diet, accumulate in high concentrations in the human retina and efficiently protect against oxidative stress. The unique spatial distributions of macular xanthophylls-lutein, zeaxanthin, and meso-zeaxanthin-in the retina play a key role in maximizing the protection of the retina by these xanthophylls.
Review
Physics, Atomic, Molecular & Chemical
Witold K. Subczynski, Justyna Widomska, Natalia Stein, Harold M. Swartz
Summary: This review delves into the important role of oxygen in FLASH, focusing on the rate of oxygen diffusion and factors influencing oxygen permeation in cell plasma membranes.
APPLIED MAGNETIC RESONANCE
(2021)
Review
Biochemistry & Molecular Biology
Witold Karol Subczynski, Marija Raguz, Justyna Widomska
Summary: EPR spin labeling is extensively used to study lipids in model membranes and understand their structures and dynamics in biological membranes. By using continuous wave EPR and saturation recovery EPR techniques, important information about lipid orientation, diffusion, flip-flop rate, and membrane hydrophobicity can be obtained.
Article
Biochemistry & Molecular Biology
Witold K. Subczynski, Justyna Widomska
Summary: This study demonstrates a linear relationship between the spin-lattice relaxation rate and rotational diffusion coefficients of lipid spin labels. The results provide a precise description of membrane fluidity and allow for easy comparison with other membrane fluidity data.
Review
Biochemistry & Molecular Biology
Justyna Widomska, Witold K. Subczynski, Renata Welc-Stanowska, Rafal Luchowski
Summary: Lutein, zeaxanthin, and meso-zeaxanthin are macular pigments that modify the physical properties of lipid bilayers similar to cholesterol. It is unclear if they directly exist in the lipid phase or form complexes with membrane proteins in the retina. Understanding their mechanisms is important for studying carotenoid-membrane interaction and how they affect membrane properties related to structure and dynamics. This review focuses on the properties of lutein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Renata Welc-Stanowska, Rafal Pietras, Bohun Mielecki, Marcin Sarewicz, Rafal Luchowski, Justyna Widomska, Wojciech Grudzinski, Artur Osyczka, Wieslaw I. Gruszecki
Summary: In this study, the antioxidant activity of carotenoids in biomembranes was investigated. The quenching activity of lutein and zeaxanthin in singlet oxygen generation was measured in lipid vesicles using a fluorescent probe and fluorescence lifetime imaging microscopy. The results showed that xanthophylls act as a barrier to the penetration of molecular oxygen into lipid membranes, especially in the 13-cis configuration. This photoisomerization of xanthophylls is a regulatory mechanism important for light filtration and photoprotection.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Witold K. Subczynski, Marta Pasenkiewicz-Gierula, Justyna Widomska, Laxman Mainali, Marija Raguz
CELL BIOCHEMISTRY AND BIOPHYSICS
(2017)
Article
Biochemistry & Molecular Biology
Justyna Widomska, Witold K. Subczynski, Laxman Mainali, Marija Raguz
CELL BIOCHEMISTRY AND BIOPHYSICS
(2017)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
