Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 45, Issue 4, Pages 425-433Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.04.037
Keywords
gamma-Tocopherol; Smoke inhalation injury; Burn; Acute lung injury; Ovine model; Free radicals
Funding
- National Institute for General Medical Sciences [GM66312, GM060688]
- Shriners of North America [8954, 8450, 8460]
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Fire accident victims who sustain both thermal injury to skin and smoke inhalation have gross evidence of systemic and pulmonary oxidant damage and acute lung injury. We hypothesized that gamma-tocopherol (gT), a reactive O-2 and N-2 scavenger, when delivered into the airway, would attenuate lung injury induced by burn and smoke inhalation. Acute lung injury was induced in chronically prepared, anesthetized sheep by 40% total burn surface area, third-degree skin burn and smoke insufflation (48 breaths of cotton smoke, < 40 degrees C). The study groups were: (1) Sham (not injured, flaxseed oil (FO)-nebulized, n = 6); (2) SA-neb (injured, saline-nebulized, n = 6); (3) FO-neb (injured, FO-nebulized, n = 6); and (4) gT+FO-neb (injured, gT and FO-nebulized, n = 6). Nebulization was started 1 h postinjury, and 24 ml of FO with or without gT (51 mg/ml) was delivered into airways over 47 h using our newly developed lipid aerosolization device (droplet size: 2.5-5 mu m). The burn- and smoke inhalation-induced pathological changes seen in the saline group were attenuated by FO nebulization; gT addition further improved pulmonary function. Pulmonary gT delivery along with a FO source may be a novel effective treatment strategy in management of patients with acute lung injury.
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