Article
Immunology
Jian Zeng, Huan Yu, Hua-Tian Gan
Summary: GDNF treatment facilitates macrophage polarization and regulates inflammatory response to suppress DSS-induced colitis in mice. Activation of the PI3K/AKT pathway may contribute to this regulation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Muhammad S. Aldhshan, Gursagar Jhanji, Nicole J. Poritsanos, Tooru M. Mizuno
Summary: This study found that increased local glucose concentration stimulates GDNF expression and inhibits MANF expression in microglia, leading to suppressed appetite. Furthermore, this regulation is associated with GLUT5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ane Escobar, Mariana R. Carvalho, F. Raquel Maia, Rui L. Reis, Tiago H. Silva, Joaquim M. Oliveira
Summary: This study demonstrates the effectiveness of using CMCht/PAMAM NPs as a GDNF release system for peripheral nerve regeneration, providing stable GDNF release under physiological conditions and improving cell viability as well as enhancing the uptake rate of neural cells.
Article
Biochemistry & Molecular Biology
Tatsuya Iwasaki, Koji Akeda, Koki Kawaguchi, Junichi Yamada, Takahiro Hasegawa, Norihiko Takegami, Tatsuhiko Fujiwara, Akihiro Sudo
Summary: NRTN, ARTN, PSPN, and their receptors are expressed in human IVD cells and their expression is enhanced in advanced degeneration, suggesting their involvement in the pathogenesis of discogenic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Luyu Ding, Yifan Wu, Lingtao Kong, Jiaze Sun, Fangru Qu, Kaiqi Xin, Anqi Yang, Xintong Yan, Yihui Lu, Xiaowei Jiang, Yanqing Tang, Feng Wu
Summary: This study investigates whether the glial cell line-derived neurotrophic factor (GDNF) levels differ in terms of gender in patients with bipolar disorder (BD). The results show that in the healthy control group, males have significantly higher GDNF levels compared to females, while in the BD group, males have significantly lower GDNF levels compared to males in the healthy control group.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Maria S. Gavrish, Mark D. Urazov, Tatiana A. Mishchenko, Victoria D. Turubanova, Ekaterina A. Epifanova, Victoria G. Krut', Alexey A. Babaev, Maria V. Vedunova, Elena Mitroshina
Summary: The role of neurotrophic factors BDNF and GDNF in maintaining brain resistance to hypoxia and promoting recovery of neural networks is being actively studied. This study aimed to evaluate the effects of overexpressing BDNF and GDNF using viral vectors in modeling hypoxia. The results showed increased survival rate of mice under hypoxic conditions, indicating that overexpression of neurotrophic factors may be a potential neuroprotection method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhe Zhang, Grace Y. Sun, Shinghua Ding
Summary: Following a focal ischemic stroke (FIS), reactive astrogliosis and glial scar formation in the peri-infarct region are triggered, leading to tissue remodeling and structural changes in the brain. GDNF, originally isolated from a rat glioma cell-line, is upregulated in reactive astrocytes (RAs) after FIS, suggesting a potential role in neuronal protection and brain recovery after stroke.
NEUROCHEMICAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Feng Wang, Hongwei Wu, Azhen Hu, Lei Dong, Xiaoxia Lin, Menghao Li, Yongling Wang, Wenjun Li, Liansheng Chang, Yuqiao Chang, Hanqing Liu, Yu Shi, Nana Li
Summary: In this study, low-frequency focused ultrasound combined with GDNF microbubbles was used to target and open the blood-brain barrier (BBB) in the ventral tegmental area (VTA). The results showed that this technique significantly increased central GDNF content, disrupted drug addiction-related conditioned place preference, reduced withdrawal symptoms of morphine addiction, and reversed changes in neurotransmitter levels induced by morphine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
N. A. Gavrilova, S. A. Borzenok, A. Revishchin, O. E. Tishchenko, D. S. Ostrovkiy, M. M. Bobrova, L. A. Safonova, A. E. Efimov, O. Agapova, M. B. Agammedov, G. Pavlova, I. I. Agapov
Summary: The study showed that silk fibroin-based scaffolds containing GDNF can stimulate the epithelialization process, increase the proliferative activity of epithelial cells and keratocytes, accelerate the formation of the stromal nerve plexus, and exhibit anti-apoptotic activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Laura Bizzozero, Margherita Pergolizzi, Davide Pascal, Elena Maldi, Giulia Villari, Jessica Erriquez, Marco Volante, Guido Serini, Caterina Marchio, Federico Bussolino, Marco Arese
Summary: The study revealed that neuroligin 1 (NLGN1) is expressed in prostatic and pancreatic cancer tissues and plays a role in promoting cancer cell invasion and migration. The neurotrophic factor glial cell line-derived neurotrophic factor (GDNF) was found to be involved in tumor-nerve interactions and cooperate with NLGN1.
Article
Neurosciences
Zehua Zou, Ruixuan Liu, Yiwen Wang, Hongjian Tan, Gang An, Baifeng Zhang, Yongzhi Wang, Daming Dong
Summary: The purpose of this study was to investigate the influence of protein arginine methyltransferase 8 (PRMT8) on neuron ferroptosis and macrophage polarization in spinal cord injury (SCI) through regulating glial cell-derived neurotrophic factor (GDNF). The results showed that PRMT8 overexpression inhibited ferroptosis and M1 macrophage polarization by increasing GDNF expression, thus alleviating SCI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
Anastasiia Kotliarova, Yulia A. Sidorova
Summary: This article summarizes the effects of GDNF family ligands on neuropathic pain and neuroinflammation, as well as the potential therapeutic implications of targeting GFL receptors in neurodegenerative disorders and neuropathic pain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Emergency Medicine
Yu Zhang, Shuhai Yang, Chang Liu, Xiaoxiao Han, Xiaosong Gu, Songlin Zhou
Summary: Spinal cord injury often results in permanent disability due to the loss of functional recovery. The formation of a glial scar around the damaged tissue can interrupt the healing process, and therapeutic treatments targeting scar components are important for improving functional recovery.
Article
Neurosciences
Shu-Yan Tong, Rui-Wen Wang, Qian Li, Yi Liu, Xiao-Yan Yao, De-Qin Geng, Dian-Shuai Gao, Chao Ren
Summary: This study examined the correlation between serum GDNF concentration and executive function performance in Parkinson's disease. The results showed that the decrease in serum GDNF concentration in PD patients is associated with impairments in inhibitory control, cognitive flexibility, and attention.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
William W. Wright
Summary: This review focuses on the in vivo regulation of spermatogonial stem cells (SSCs) in adult testes by glial cell line-derived neurotrophic factor (GDNF). Through chemical-genetic approach, the inhibition of GDNF stimulation of SSCs was found to decrease replication and increase differentiation of SSCs, ultimately leading to the loss of all SSCs and resembling the condition of Sertoli cell-only (SCO) syndrome. Abnormally low expression of GDNF, FGF2, and FGF8 was observed in infertile human testes, although some SCO testes still contain SSCs. Restoration of GDNF signaling showed partial rebuilding of depleted SSC pool, suggesting GDNF as a potential therapy for men with SCO syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lisa S. Foley, David A. Fullerton, Daine T. Bennett, Kirsten A. Freeman, Joshua Mares, Marshall T. Bell, Joseph C. Cleveland, Michael J. Weyant, Xianzhong Meng, Ferenc Puskas, T. Brett Reece
ANNALS OF THORACIC SURGERY
(2015)
Article
Surgery
Kirsten A. Freeman, Ferenc Puskas, Marshall T. Bell, Joshua M. Mares, Lisa S. Foley, Michael J. Weyant, Joseph C. Cleveland, David A. Fullerton, Xianzhong Meng, Paco S. Herson, T. Brett Reece
JOURNAL OF SURGICAL RESEARCH
(2015)
Article
Cardiac & Cardiovascular Systems
Joshua M. Mares, Lisa S. Foley, Marshall T. Bell, Daine T. Bennett, Kirsten A. Freeman, Xianzhong Meng, Michael J. Weyant, Joseph C. Cleveland, David A. Fullerton, Ferenc Puskas, Thomas Brett Reece
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2015)
Article
Cardiac & Cardiovascular Systems
Marshall T. Bell, Ferenc Puskas, Viktor A. Agoston, Joseph C. Cleveland, Kirsten A. Freeman, Fabia Gamboni, Paco S. Herson, Xianzhong Meng, Phillip D. Smith, Michael J. Weyant, David A. Fullerton, T. Brett Reece
Article
Surgery
Marshall T. Bell, Viktor A. Agoston, Kirsten A. Freeman, Ferenc Puskas, Paco S. Herson, Joshua Mares, David A. Fullerton, T. Brett Reece
JOURNAL OF VASCULAR SURGERY
(2014)
Article
Multidisciplinary Sciences
Marshall T. Bell, T. Brett Reece, Phillip D. Smith, Joshua Mares, Michael J. Weyant, Joseph C. Cleveland, Kirsten A. Freeman, David A. Fullerton, Ferenc Puskas
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2014)
Article
Cardiac & Cardiovascular Systems
Melissa Taylor, Tyler Wallen, J. Hunter Mehaffey, Ali Shirafkan, Alexander A. Brescia, Kirsten Freeman, Clauden Louis, Justin Watson, Ikenna Okereke
Summary: This article provides the contact information for Dr Okereke.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Henry R. Holmes, Dan Neal, Kirsten Freeman, Eric Jeng, Martin Back, Thomas Huber, K. Dean Arnaoutakis, Samir Shah, Gilbert R. Upchurch Jr, Michol Cooper, Thomas M. Beaver, Tomas D. Martin, George J. Arnaoutakis
Summary: This study assessed the misdiagnosis of acute aortic syndromes (AASs) among patients transferred to a tertiary care facility and found differences between transferring diagnosis and actual diagnosis. Misdiagnoses were primarily caused by misinterpretation of radiographic imaging, and repeat scans were performed in some cases. Improving physician awareness and implementing centralized web-based imaging can help prevent unnecessary emergency transfers.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Melissa Taylor, Kirsten Freeman, J. Hunter Mehaffey, Tyler Wallen, Ikenna C. Okereke
Summary: Virtual interviews in cardiothoracic fellowship applications were well-received, but some applicants were still unable to fully evaluate programs. Interactions with fellows were highly valued, while program social media sites were least important.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Matheus Falasa, Henry R. Holmes, Daniel Neal, Calvin Y. Choi, Ki Park, Anthony A. Bavry, Kirsten A. Freeman, Eddie W. Manning, Wade W. Stinson, Eric Jeng
Summary: This study compared the costs and outcomes of surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). The results showed that in propensity-matched groups, TAVR was associated with shorter ICU and hospital LOS and OR times but increased permanent pacemaker rates. In addition, while 1-year survival was similar between groups, SAVR had significantly improved 3-year and 5-year survival.
INNOVATIONS-TECHNOLOGY AND TECHNIQUES IN CARDIOTHORACIC AND VASCULAR SURGERY
(2022)
Article
Surgery
Henry R. Holmes, Matheus Falasa, Daniel Neal, Calvin Y. Choi, Ki Park, Anthony A. Bavry, Kirsten A. Freeman, Eddie W. Manning, Wade W. Stinson, Eric Jeng
Summary: This study compared outcomes and costs between MAC and GA for TAVR at a Veterans Affairs Medical Center. The results showed that using MAC can improve OR time efficiency, decrease LOS, and reduce 180-day mortality compared to GA.
INNOVATIONS-TECHNOLOGY AND TECHNIQUES IN CARDIOTHORACIC AND VASCULAR SURGERY
(2022)