Journal
FORENSIC SCIENCE INTERNATIONAL
Volume 245, Issue -, Pages 126-132Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.forsciint.2014.10.016
Keywords
3-MMC; 5-APB; Intoxication; Analysis
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The emergence of a large number of new psychoactive substances (NPSs) in recent years poses a serious problem to clinical and forensic toxicologists. Here we report a patient who administrated ca. 500 mg of 3-MMC (3-methyl-N-methylcathinone) and 400 mg of 5-APB (5-(2-aminopropyl)benzofuran) in combination with 80 g of ethyl alcohol. The clinical manifestations included agitation, seizures, hypertension, tachycardia, hyperthermia and bradycardia. The patient did not recover and died around 4 h after the use of drugs. The cause of death was acute cardiovascular collapse that occurred following mixed intoxication with NPSs and alcohol. Toxicological analysis of post-mortem blood revealed 3-MMC and 5-APB in concentrations of 1.6 mu g/mL and 5.6 mu g/mL, respectively. Moreover, the serum alcohol concentration was 1.4 g/L in ante-mortem sample collected 1 h after admission to the hospital. This is the first report on blood concentration of 3-MMC and 5-APB in fatal intoxication. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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