Article
Surgery
Zhi-Hui Liang, Yue-Hui Zhang, Hai-Tao Liu, Qiu-Qi Zhang, Jia Song, Jiang Shao
Summary: This study compared the clinical outcomes of structural autografts from the occipital bone or iliac crest in pediatric patients. The results showed that occipital bone grafts had advantages over iliac bone grafts in terms of operation time, blood loss, and length of hospitalization, with a lower risk of complications.
FRONTIERS IN SURGERY
(2023)
Article
Orthopedics
Jiaxun Jiao, Jiaqi Li, Yun Luo, Wei Zhang
Summary: This retrospective study found that Modic changes did not impact fusion rates and clinical outcomes of transforaminal lumbar interbody fusion. However, MCs-1 increased the risk of cage subsidence and showed superior outcomes in terms of visual analog scale scores for low back pain.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Pharmacology & Pharmacy
X-J Liu, Q-S Zhu, H-F Sun, X-J Song, C-L Wang, Y-T Wu, Y-H Ma
Summary: This meta-analysis suggests that the clinical application of HA and its related composite materials in spinal reconstruction is comparable to that of autologous bone, with satisfactory efficacy and safety.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Grayson M. Talaski, Anthony N. Baumann, Albert T. Anastasio, Kempland C. Walley, Cesar de Cesar Netto
Summary: This systematic review evaluates different bone graft types for salvage MTP arthrodesis in terms of clinical outcomes, kinematic outcomes, and bony integration. The results suggest that the allograft group has the best length restoration and the lowest complication rate, but more high-quality research is needed to further confirm these findings.
APPLIED SCIENCES-BASEL
(2023)
Article
Cell & Tissue Engineering
Yongfeng Li, Huawei Liu, Chao Wang, Rongzeng Yan, Lei Xiang, Xiaodan Mu, Lingling Zheng, Changkui Liu, Min Hu
Summary: This study aimed to fabricate 3D-printing titanium grid scaffolds to achieve bone fusion in mandibular segmental defects. The results showed that the scaffolds with sufficient pores and basic biomechanical strength could facilitate bone regeneration and integration of bone broken ends. Clinical observations on both animal models and patients confirmed the successful bone regeneration in mandibular defects using the titanium grid scaffolds.
NPJ REGENERATIVE MEDICINE
(2023)
Letter
Cell & Tissue Engineering
Victoria Gomez-Ruiz, Juan F. Blanco, Eva M. Villaron, Helena Fidalgo, Miriam Lopez-Parra, Fermin Sanchez-Guijo
Summary: In this study, we conducted a 10-year follow-up investigation on patients with degenerative disc disease undergoing spinal fusion. The use of autologous mesenchymal stem cells embedded in tricalcium phosphate was found to be safe and effective in alleviating low back pain, radicular pain, and improving quality of life.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Cristiano Magalhaes Menezes, Gabriel Carvalho Lacerda, Germano Senna Oliveira do Valle, Andre de Oliveira Arruda, Erica Godinho Menezes
Summary: This study evaluated the clinical success of a commercial ceramic bone graft substitute (CBGS) for autograft in eXtreme Lateral Interbody Fusion (XLIF) procedures. The fusion rates at 24 months were 96.4% and 100% for CBGS and autograft groups, respectively, with similar improvements in back pain and leg pain observed between the two groups.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Vijay Letchuman, Leonel Ampie, Winward Choy, Joseph D. DiDomenico, Hasan R. Syed, Avery L. Buchholz
Summary: Pediatric spinal fusions have high nonunion rates, leading to the development of various bone grafts and biologics to promote bone formation and fusion. The current gold-standard bone graft is autologous bone, but it comes with postoperative pain and morbidity. Other bone graft substitutes and biologics require more research specific to the pediatric population.
NEUROSURGICAL FOCUS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hendrik Terheyden, Sophia Mulugeta Abraha, Hendrik Naujokat
Summary: Interpositional osteoplasties are safe and effective for vertical augmentation of edentulous jaws, with high success rates. However, there is a 32% complication rate in the maxilla and 45% rate in the mandible, highlighting the importance of thorough patient-doctor communication.
Article
Clinical Neurology
Chi-An Luo, Wen-Chien Chen, Meng-Ling Lu, Ping-Yeh Chiu, Chen-Ju Fu, Chi-Chien Niu
Summary: This study compared the efficacy of bone graft substitutes and found that lumbar fusion surgery using demineralized bone matrix (DBM) and biphasic calcium phosphate (BCP) achieved similar clinical outcomes, with a higher fusion rate in the BCP group for two-level surgery.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
Toshitaka Yoshii, Motonori Hashimoto, Satoru Egawa, Takashi Hirai, Hiroyuki Inose, Atsushi Okawa
Summary: The study demonstrated that the use of hydroxyapatite/collagen composite with bone marrow aspirate as a substitute for autologous bone graft in intervertebral spinal fusion resulted in a high complete fusion rate in patients, comparable to traditional local bone grafts.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Orthopedics
Jin Yang, Yong Yang, Gaoju Wang, Shuang Xu, Guangzhou Li, Shuai Zhang, Chaohua Yang, Song Wang, Qing Wang
Summary: This study found that using local autogenous morselized bone (LAMB) during posterior-transforaminal lumbar interbody fusion (P-TLIF) can achieve excellent clinical and radiographic outcomes. The fusion status, bone volume, and clinical results were evaluated using computed tomography. The results showed that the volume of LAMB harvested is sufficient for achieving solid interbody fusion in the lower lumbar spine, with significant improvement in clinical symptoms after surgery.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Chemistry, Multidisciplinary
Munusamy Ramadas, Ravichandran Abimanyu, Jose M. F. Ferreira, Anbalagan M. Ballamurugan
Summary: This study reports on the fabrication and characterization of 3D magnesium substituted bi-phasic calcium phosphate scaffolds by gel-casting, as well as their in vitro and in vivo performances. The scaffolds exhibited good biomineralization activity and biocompatibility, and successfully restored bone defects in an animal model.
Article
Orthopedics
Changsheng Yang, Wentao Zhuo, Qingchu Li, Caiqiang Huang, Huibo Yan, Dadi Jin
Summary: The study found that autogenous iliac bone is the most ideal bone graft for anterior cervical discectomy and fusion. Allogeneic bone can be an acceptable substitute, but carries a risk of cage subsidence and dysphagia. Hydroxyapatite has a lower fusion rate and a higher risk of cage subsidence. Further research is needed to explore better substitutes for ACDF.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Clinical Neurology
Michael A. Bohl, Edward M. Reece, Farrokh Farrokhi, Matthew J. Davis, Amjed Abu-Ghname, Alexander E. Ropper
Summary: This study describes the use of a multidisciplinary approach to enhance bony arthrodesis in the supraaxial cervical spine using an occipital bone graft. The technique of utilizing a vascularized bone graft instead of nonvascularized options has proven to improve spine healing and fusion. The feasibility of using this vascularized bone graft offers new possibilities for complex spine surgeries.
OPERATIVE NEUROSURGERY
(2021)
