Article
Food Science & Technology
Linlin Tian, Changcheng Zhong, Yao He, Qingzi Lu, Yanghong Wang, Xiangxiang Zhao, Hua Wei, Xueying Tao
Summary: This study aimed to screen probiotic strains to prevent S. Typhimurium infection and explore their mechanisms. Lacticaseibacillus casei WLCA02 was selected and investigated for its potential pro-tective mechanism against S. Typhimurium. Results showed that WLCA02 could reduce Salmonella loads in mice, enhance the intestinal barrier, alleviate inflammation, and activate macrophages. These findings suggest that WLCA02 has potential as an antibacterial functional food.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Immunology
Bingjie Duan, Lina Shao, Ruihan Liu, Petunia Msuthwana, Jingtao Hu, Chunfeng Wang
Summary: LGG modulates M1 macrophage polarization, enhances phagocytosis and bactericidal ability, and protects against S. Typhimurium infection. Additionally, LGG alleviates inflammatory response and dissemination caused by S. Typhimurium, providing a protective effect against infection.
MICROBIAL PATHOGENESIS
(2021)
Article
Biochemical Research Methods
Sicheng Tian, Chuan Wang, Yongyu Li, Xiaoming Bao, Yunwen Zhang, Tian Tang
Summary: SlyA is an important transcriptional regulator in Salmonella typhimurium, affecting the virulence and cell metabolism of the bacterium. Deletion of slyA impairs cell growth and alters several glycolytic and lipid metabolism pathways in S. typhimurium. Transcriptional analysis showed downregulation of genes associated with glycolysis and lipid turnover in the absence of slyA.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chenpei Zhao, Huan Chen, Hao Liang, Xiaoyu Zhao, Wenli Tang, Maolian Wei, Youzhi Li, Jianlong Zhang, Xin Yu, Guozhong Chen, Hongwei Zhu, Linlin Jiang, Xingxiao Zhang
Summary: Probiotic Lactobacillus plantarum RS-09 has been found to modulate M1 macrophage polarization and induce TLR2-linked NF-kappa B signaling activity, enhancing the immune response against Salmonella Typhimurium infection. Additionally, RS-09 relieves splenomegaly, body weight loss, and death rate associated with the infection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Lingyan Jiang, Peisheng Wang, Xiaorui Song, Huan Zhang, Shuangshuang Ma, Jingting Wang, Wanwu Li, Runxia Lv, Xiaoqian Liu, Shuai Ma, Jiaqi Yan, Haiyan Zhou, Di Huang, Zhihui Cheng, Chen Yang, Lu Feng, Lei Wang
Summary: S. Typhimurium infection induces upregulated glycolysis and decreased serine synthesis in host macrophages, leading to accumulation of glycolytic intermediates that promote bacterial replication and virulence.
NATURE COMMUNICATIONS
(2021)
Article
Food Science & Technology
Shamsun Nahar, Ha Lim Jeong, Younsoo Kim, Angela Jie-won Ha, Pantu Kumar Roy, Si Hong Park, Md Ashrafudoulla, Md Furkanur Rahaman Mizan, Sang-Do Ha
Summary: The inhibitory properties of Flavourzyme against Salmonella enterica and Shiga toxin-producing Escherichia coli were evaluated, showing significant inhibition of biofilm formation and quorum sensing activity, along with suppression of gene expression related to biofilm formation, quorum sensing, and virulence.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Microbiology
Charlotte Michaux, Severin Ronneae, Rachel T. Giorgio, Sophie Helaine
Summary: Genetically susceptible bacteria can escape the action of antibiotics through antibiotic tolerance or persistence. Tolerance affects the entire bacterial population while persistence only impacts a subset of cells. Tolerance-inducing conditions can mask persistence and impair bacterial proliferation during infection.
Article
Biochemistry & Molecular Biology
Yunzhe Su, Taotao Sun, Junhan Gao, Chenxu Zhang, Xuesheng Liu, Chongpeng Bi, Jiajun Wang, Anshan Shan
Summary: Salmonella typhimurium is a common cause of food poisoning, leading to intestinal inflammation, barrier damage, and impaired nutrient absorption. The anti-proteolytic peptide R7I shows protective effects against Salmonella typhimurium infection by reducing inflammation, enhancing antioxidant capacity, and restoring intestinal integrity and fatty acid absorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Muna Aqawi, Ronit Vogt Sionov, Michael Friedman, Doron Steinberg
Summary: The non-psychoactive compound cannabigerol (CBG) from Cannabis sativa L. has antibacterial and anti-biofilm activities against Streptococcus mutans. This study investigates the susceptibility of S. mutans to CBG and the effects on the QS systems ComCDE and LuxS. The results reveal that CBG affects the ComCDE and LuxS QS pathways and has potential as an anti-QS compound for S. mutans.
Article
Immunology
Anne-Marie Chausse, Sylvie M. Roche, Marco Moroldo, Christelle Hennequet-Antier, Sebastien Holbert, Florent Kempf, Emilie Barilleau, Jerome Trotereau, Philippe Velge
Summary: This study describes the transcriptomic reprogramming of IEC-6 intestinal epithelial cell line to Salmonella Typhimurium strains that invaded cells by trigger or zipper mechanisms. Regardless of the entry mechanism, the transcriptomic reprogramming of the cell was similar. However, when comparing gene expression between exposed and unexposed cells, the transcriptomic reprogramming of exposed cells was significantly different, indicating the impact of Salmonella infection. The activation of target genes of the aryl hydrocarbon receptor and modulation of extracellular matrix genes were observed during Salmonella infection.
Article
Biochemistry & Molecular Biology
Manuel Grander, Alexander Hoffmann, Markus Seifert, Egon Demetz, Philipp Grubwieser, Christa Pfeifhofer-Obermair, David Haschka, Guenter Weiss
Summary: Macrophages play a crucial role in innate immunity by controlling iron trafficking and infection. The study shows that DMT1 is essential for iron uptake and storage in macrophages, and its absence leads to impaired control of siderophilic bacteria infection. This highlights the importance of DMT1 in nutritional immunity and iron delivery for infection control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yuanze Gao, Helin Chen, Wen Li, Yu Zhang, Jie Luo, Ling Zhao, Fei Shi, Gang Ye, Xiaoli He, Zhiwen Xu, Ling Zhu, Huaqiao Tang, Yinglun Li
Summary: This study evaluated the effect of chloroform extracts from Atractylodes chinensis on the virulence of Salmonella Typhimurium (STM) and found that it could attenuate the adhesion and invasion abilities of STM, as well as inhibit the expression of genes related to adhesion and invasion. It also downregulated the expression of inflammatory cytokines and restored the expression of intestinal barrier-related genes and proteins damaged during STM infection.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
F. Campioni, C. N. Gomes, A. M. M. Bergamini, D. P. Rodrigues, M. R. Tiba-Casas, J. P. Falcao
Summary: This study compared the ability of Salmonella enterica serovars Enteritidis and Dublin to invade, survive within, and stimulate cytokine release in various host cells. It found that compared to Enteritidis, Dublin has a stronger ability to survive within macrophages and induces weaker cytokine production, potentially explaining the differences in disease incidence caused by these two serovars.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenshu Zou, Jingyan Zhang, Kai Zhang, Zhiping Peng, Ruihua Xin, Lei Wang, Jianxi Li
Summary: This study found that Asiatic acid (AA) can attenuate microglial inflammation induced by Salmonella typhimurium (S.T). AA upregulated the expression of lncRNA TVX1, leading to the suppression of pro-inflammatory factors and inhibition of the NF-κB pathway and NLRP3 inflammasome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Bijit K. Bhowmik, Arvind Kumar, Dharanesh Gangaiah
Summary: This study provides insights into the invasion and intracellular survival phenotypes of Salmonella enterica vaccine strain and its derivatives, as well as the transcriptome response of host macrophages. The findings could contribute to the development of next-generation vaccines with improved safety.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Environmental Sciences
Pierangeli G. Vital, Nguyen Thi Van Ha, Le Thi Hong Tuyet, Kenneth W. Widmer
JOURNAL OF WATER AND HEALTH
(2017)
Article
Virology
Lauren N. Luethy, Andrea K. Erickson, Palmy R. Jesudhasan, Mine Ikizler, Terence S. Dermody, Julie K. Pfeiffer
Article
Microbiology
Elizabeth R. Aguilera, Andrea K. Erickson, Palmy R. Jesudhasan, Christopher M. Robinson, Julie K. Pfeiffer
Article
Microbiology
Andrea K. Erickson, Palmy R. Jesudhasan, Melinda J. Mayer, Arjan Narbad, Sebastian E. Winter, Julie K. Pfeiffer
CELL HOST & MICROBE
(2018)
Article
Virology
Y. Nguyen, Palmy R. Jesudhasan, Elizabeth R. Aguilera, Julie K. Pfeiffer
JOURNAL OF VIROLOGY
(2019)
Article
Multidisciplinary Sciences
Pauline Dianne M. Santos, Kenneth W. Widmer, Windell L. Rivera
Article
Biochemistry & Molecular Biology
Mahsa Sorouri, Tyron Chang, Palmy Jesudhasan, Chelsea Pinkham, Nels C. Elde, Dustin C. Hancks
Article
Agriculture, Dairy & Animal Science
Palmy R. Jesudhasan, Sohini S. Bhatia, Kirthiram K. Sivakumar, Chandni Praveen, Kenneth J. Genovese, Haiqi L. He, Robert Droleskey, Jack L. McReynolds, James A. Byrd, Christina L. Swaggerty, Michael H. Kogut, David J. Nisbet, Suresh D. Pillai
Summary: Clostridium perfringens (Cp) is a bacterium causing necrotic enteritis in chickens, leading to significant economic losses in the poultry industry worldwide. Contaminated chicken meat can lead to foodborne illnesses in humans. Electron beam irradiation (eBeam) inactivates Cp effectively for use as a vaccine, reducing colonization in broiler chickens.
Article
Multidisciplinary Sciences
Chandni Praveen, Sohini S. Bhatia, Robert C. Alaniz, Robert E. Droleskey, Noah D. Cohen, Palmy R. Jesudhasan, Suresh D. Pillai
Summary: This study explores the effectiveness of electron beam-inactivated immune modulators by assessing their impact on dendritic cells and mice models. The results show that EBST has the potential as vaccine candidates, offering both the safety of a killed vaccine and the immunogenicity of an attenuated vaccine. The ability to store EBST at different temperatures without loss of potency makes it a promising new vaccine production technology.
Article
Microbiology
Basanta R. Wagle, Annie M. Donoghue, Palmy R. Jesudhasan
Summary: The study demonstrates that allyl sulfide and ginger oil can significantly reduce Campylobacter in poultry meat, while curcumin and other phytochemicals also reduce adhesion and quorum sensing of the bacteria, leading to cell membrane damage or death.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Alyzza Marie B. Calayag, Kenneth W. Widmer, Windell L. Rivera
Summary: A study in the Philippines revealed that a significant portion of Salmonella enterica isolates from pork carry antimicrobial resistance genes, with some showing multidrug resistance. This raises concerns about antimicrobial use in the Philippine hog industry and the potential transmission of resistance genes to other bacteria.
Article
Agriculture, Dairy & Animal Science
Kelsy Robinson, Anna L. F. Assumpcao, Komala Arsi, Gisela F. Erf, Annie Donoghue, Palmy R. R. Jesudhasan
Summary: The research demonstrates the ability of Salmonella to alter the intestinal microbiota composition and highlights potential probiotics for combating Salmonella colonization. Additionally, the study indicates the early involvement of monocytes and thrombocytes during colonization, followed by heterophils.
Article
Agriculture, Dairy & Animal Science
Kelsy Robinson, Anna L. F. Assumpcao, Komala Arsi, Annie Donoghue, Palmy R. R. Jesudhasan
Summary: The study found that garlic and ginger oils have great potential to reduce the prevalence of Salmonella in the processing environment, with significant reductions in Salmonella levels observed. The oils have antimicrobial activity and can inhibit the ability of Salmonella to adhere to host cells, demonstrating their effectiveness as natural alternatives to reduce contamination.
Article
Agriculture, Dairy & Animal Science
Basanta R. Wagle, Austin Quach, Seungjun Yeo, Anna L. F. V. Assumpcao, Komala Arsi, Annie M. Donoghue, Palmy R. R. Jesudhasan
Summary: This study identified key host factors modulated by Campylobacter colonization using a novel LCMS-based multiomics technology. The results provide potential targets for controlling Campylobacter in broiler chickens.
Article
Environmental Sciences
Muthukumar Abinaya, Sathappan Shanthi, Jesudasan Palmy, Khalid A. Al-Ghanim, Marimuthu Govindarajan, Baskaralingam Vaseeharan
Summary: This study evaluated the efficacy of exopolysaccharides (EPSs) from probiotic Bacillus licheniformis and EPS-mediated zinc oxide nanoparticles (EPS-ZnO NPs) as feed additives for Mozambique tilapia. The results showed that a diet supplemented with EPS and EPS-ZnO NPs improved the growth performance, immune response, antioxidant activity, and disease resistance of the fish.