Article
Agriculture, Multidisciplinary
Md Yousof Ali, Sumera Zaib, Susoma Jannat, Imtiaz Khan
Summary: Ginsenoside derivatives exhibit significant inhibitory effects on ACE, with protopanaxatriol, protopanaxadiol, and ginsenoside Rh2 showing the most potent inhibition. Molecular docking studies confirmed that ginsenosides inhibit ACE through hydrogen bonds and hydrophobic interactions. Additionally, ginsenosides also stimulate glucose uptake in insulin-resistant cells and have antioxidant properties.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang
Summary: The study found that plasma midkine levels were significantly elevated in sepsis patients and closely related to the ACE system. In a mouse model, increased midkine levels were associated with more severe lung injury. Regional interference of midkine expression in lung tissue was shown to alleviate acute lung injury.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Food Science & Technology
Jingjing Dong, Shen Wang, Xiaoyao Yin, Min Fang, Zhiyong Gong, Yongning Wu
Summary: This study investigated the antihypertensive effect of rice peptide (RP) and revealed its mechanism of action. The results demonstrated that RP could effectively reduce systolic blood pressure in hypertensive rats, potentially through regulating the renin-angiotensin system and nitric oxide release.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Zehra Bas
Summary: ACE plays a crucial role in regulating blood pressure, and inhibiting this enzyme is a significant drug target for hypertension treatment. Nicotinamide and GSH peptides were found to have inhibitory effects on ACE activity, with GSH peptide showing higher inhibitory activity. These compounds may have protective and therapeutic effects against hypertension.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Clinical Neurology
Malik Nassan, Iyas Daghlas, Ignazio S. Piras, Emily Rogalski, Lianne M. Reus, Yolande Pijnenburg, Leah K. Cuddy, Richa Saxena, M-Marsel Mesulam, Matt Huentelman
Summary: This study used genetic approaches to find that angiotensin-converting enzyme (ACE) inhibition is associated with Alzheimer's disease and frontotemporal dementia, but not with Lewy body dementia or vascular dementia. These results provide evidence for further research on the neurocognitive effects of ACE inhibition.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Seok-Chun Ko, Ji-Yul Kim, Jeong Min Lee, Mi-Jin Yim, Hyun-Soo Kim, Gun-Woo Oh, Chul Hwan Kim, Nalae Kang, Soo-Jin Heo, Kyunghwa Baek, Dae-Sung Lee
Summary: This study aimed to investigate the ACE-inhibitory effects of meroterpenoids isolated from the brown alga, Sargassum macrocarpum, and their molecular mechanisms. The results showed that meroterpenoids from S. macrocarpum exhibited strong ACE-inhibition, mainly attributed to the interactions between meroterpenoids and ACE. These findings suggest that S. macrocarpum could be a potential source for manufacturing antihypertensive nutraceutical ingredients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Nishithkumar Jogi, Undiganalu Gangadharappa Yathisha, Ishani Bhat, Bangera Sheshappa Mamatha
Summary: Food proteins are sources for ACE-I inhibitory peptides that can be extracted by enzymatic hydrolysis and exhibit anti-hypertensive activity. However, these peptides are susceptible to degradation by gastrointestinal enzymes during oral consumption. The bio-activity of ACE-I inhibitory peptides is dependent on their intact absorption after gastrointestinal digestion.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cell Biology
Alexandra M. Garvin, Bilal S. Khokhar, Michael P. Czubryt, Taben M. Hale
Summary: Angiotensin II is a key mediator of profibrotic signaling in the heart, impacting cardiac function and mortality. Inhibitors of Ang II production or action, known as RAS inhibitors, are the first line therapeutics for heart failure, with potential for long-lasting effects on cardiac fibroblast responses.
CELLULAR SIGNALLING
(2021)
Article
Peripheral Vascular Disease
Ana R. Gaspar, Beatriz Andrade, Sara Mosca, Mariana Ferreira-Duarte, Ana Teixeira, Dina Cosme, Antonio Albino-Teixeira, Fernanda A. Ronchi, Ana P. Leite, Dulce E. Casarini, Jose C. Areias, Teresa Sousa, Alberto C. Afonso, Manuela Morato, Liane Correia-Costa
Summary: This study found that childhood obesity is associated with increased activities of angiotensin-converting enzymes (ACE) and ACE2. Overweight/obese children had significantly higher ACE and ACE2 activities compared to normal weight children. In girls, ACE and ACE2 activities were associated with increased night-time systolic and diastolic blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Urszula Tyrankiewicz, Mariola Olkowicz, Piotr Berkowicz, Magdalena Jablonska, Ryszard T. Smolenski, Jerzy A. Zoladz, Stefan Chlopicki
Summary: The study found that combined spontaneous physical activity and ACE-I treatment had additive beneficial effects on ACE/ACE-2 balance in a mouse model of heart failure, but did not result in improvement in cardiac function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Carla Georgia Rodrigues Guimaraes Souto, Bethania Rosa Lorencone, Aline Aparecida Macedo Marques, Rhanany Alan Calloi Palozi, Paulo Vitor Moreira Romao, Lucas Pires Guarnier, Cleide Adriane Signor Tirloni, Ariany Carvalho dos Santos, Roosevelt Isaias Carvalho Souza, Priscila Megda Joao Job Zago, Francislaine Aparecida dos Reis Livero, Emerson Luiz Botelho Lourenco, Denise Brentan Silva, Arquimedes Gasparotto Junior
Summary: The ethanolic extract of Talinum paniculatum showed significant cardiorenal protective effects in rats, normalizing electrocardiographic and hemodynamic alterations, and preventing ventricle remodeling. These effects were associated with serum antioxidant activity and angiotensin-converting enzyme (ACE) inhibition, indicating potential benefits for hypertensive patients with doxorubicin-induced cardiotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Carmen Lammi, Giovanna Boschin, Martina Bartolomei, Anna Arnoldi, Gianni Galaverna, Luca Dellafiora
Summary: This study combined computational and in vitro investigations to precisely describe the chemical basis of potent inhibitory peptides. A novel and potent ACE inhibitory peptide was discovered, and the findings could serve as a blueprint for designing new inhibitory peptides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Peripheral Vascular Disease
Alexandra M. Garvin, Matthew D. De Both, Joshua S. Talboom, Merry L. Lindsey, Matthew J. Huentelman, Taben M. Hale
Summary: Transient ACE inhibition in spontaneously hypertensive rats leads to a persistent shift in cardiac fibroblast subpopulations, resulting in reduced fibrogenic phenotype.
Article
Biochemistry & Molecular Biology
Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Summary: Finger millet ethanol extracts (FEs) exhibit lipid-lowering, antioxidant, renin-angiotensin system-controlling, and vascular remodeling-improving effects in spontaneously hypertensive rats (SHRs), significantly reducing systolic blood pressure.
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
