Article
Anatomy & Morphology
Gokul Sudhakaran, Ravi Rajesh, Ajay Guru, Mariadhas Valan Arasu, Pusparathinam Gopinath, Jesu Arockiaraj
Summary: The aim of this study was to evaluate the anti-adipogenic activity of semi-natural Nimbin analogs, N5 and N7, on zebrafish larvae induced with oxidative stress due to a high-fat diet. The results showed that N5 and N7 suppressed adipogenesis, reduced intracellular ROS and superoxide anion production, and restored glutathione levels. Additionally, they lowered total TC and TG levels, prevented inflammatory macrophage build-up, and enhanced glucose absorption.
Article
Polymer Science
Chun-Hui Chiu, Kai-Chu Chiu, Li-Chan Yang
Summary: This study found that Tremella fuciformis-derived acidic heteropolysaccharides (TFPS) can ameliorate high-fat diet-induced obesity in mice by reducing weight gain, increasing fecal lipid content, and decreasing body fat percentage and serum cholesterol level.
Article
Food Science & Technology
Xu Yan, Yuanyuan Zhai, Wenling Zhou, Yuan Qiao, Lingling Guan, Hao Liu, Jizhi Jiang, Liang Peng
Summary: Rutin supplementation can alleviate obesity and metabolic disorders induced by high-fat diet through modulating the composition of intestinal flora. Rutin supplementation reduces body-weight gain, improves insulin resistance, and acts favorably on intestinal barrier, reducing endotoxemia and systemic inflammation. Antibiotic treatment and fecal microbiota transplantation demonstrate the importance of intestinal flora in the beneficial effects of rutin on obesity control.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Junting Xie, Xiaoning Hou, Wanshi He, Jie Xiao, Yong Cao, Xiaojuan Liu
Summary: Although the specific action site and signal pathway of astaxanthin in weight loss remain unclear, this study used Caenorhabditis elegans to shed light on its efficacy and specific action sites. The supplementation of 60 μM astaxanthin significantly reduced fat deposition and triglyceride levels and prevented obesity caused by excessive energy accumulation. These effects were induced by sbp-1/mdt-15 and insulin/insulin-like growth factor pathways, and co-regulated the down-regulation of specific sites fat-6 and fat-7.
Article
Biochemistry & Molecular Biology
Prince K. K. Akowuah, Carolina Lema, Rolando E. E. Rumbaut, Alan R. R. Burns
Summary: Feeding mice with a high-fat/sucrose diet causes loss of corneal nerve function and impairs corneal wound healing. Changing to a low fat/sugar diet with enrichments in complex carbohydrates mitigates the reduction in nerve function, but its effect on corneal wound healing needs further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Yan Zhu, Xianghui Zhou, Nan Ling, Qiming Yu, Huijuan Wang, Qizhen Du
Summary: This study aimed to investigate the effect of Guisangyou tea (GSY tea) on abnormal lipid metabolism in mice with obesity induced by a high-fat diet (HFD). The results showed that GSY tea decreased serum lipid levels, regulated antioxidant enzyme activities and inflammatory factors, and modulated mRNA and protein expression levels related to lipid synthesis and bile acid production in the liver. These findings indicate that GSY tea can improve abnormal lipid metabolism by enhancing antioxidant capacity, regulating inflammation, and modulating lipid synthesis and bile acid production.
Article
Food Science & Technology
Xingwei Xiang, Xiaoling Zhou, Wenjie Wang, Yufang Zhou, Xuxia Zhou, Shanggui Deng, Bin Zheng, Zhengshun Wen
Summary: KOPL treatment effectively improves symptoms in HFD-induced obese mice by reducing weight gain and fat accumulation, protecting liver and intestinal tissues, regulating inflammation, and modulating intestinal microbiota diversity. It may be a promising dietary strategy for treating obesity and related metabolic diseases.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biology
Menna H. E. Morsy, Zohour I. Nabil, Samah T. Darwish, Rasha A. Al-Eisa, Amir E. Mehana
Summary: Obesity is a major global health issue and an independent risk factor for developing type 2 diabetes. This study investigated the anti-diabetic and anti-adipogenic effects of Harmine in albino mice. The results showed that Harmine improved the detrimental effects caused by a high-fat diet, including organ weight gain, lipid metabolism abnormalities, and pathological damage.
Article
Nutrition & Dietetics
Tengteng Ji, Bing Fang, Fang Wu, Yaqiong Liu, Le Cheng, Yixuan Li, Ran Wang, Longjiao Zhu
Summary: The number of obese people is increasing worldwide due to high-fat diets causing excess energy intake. A 12-week dietary intervention study on high-fat diet-induced obese mice showed that changing the diet significantly reduced weight gain and subcutaneous adipose tissue weight. Diet change also affected lipolysis, lipogenesis, and the proportion of adipocyte stem cells in different fat tissues.
Article
Pharmacology & Pharmacy
A. Raskovi, N. Marti, D. Zaklan, N. Duborija-kovacevi, M. Vujcic, B. Andrejic-visnji, I. Capo, R. Mijovic, M. Krga, N. Pavlovic, D. Prodanovic, P. Arsenovi, O. Horvat
Summary: The study aimed to investigate the effects of carnosine and a commercial carnosine supplement on lipid status, liver and kidney function, and inflammation in rats with high-fat diet-induced hyperlipidemia. The results showed that carnosine supplementation significantly improved serum total and LDL cholesterol levels, as well as exhibited anti-inflammatory effects. Furthermore, carnosine had a good safety profile in terms of liver and kidney function.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
A. Raskovic, N. Martic, D. Zaklan, N. Duborija-Kovacevic, M. Vujcic, B. Andrejic-Visnjic, I. Capo, R. Mijovic, M. Krga, N. Pavlovic, D. Prodanovic, P. Arsenovi, O. Horvat
Summary: This study aimed to investigate the hypolipidemic effects of carnosine and a commercial carnosine supplement on lipid status, liver and kidney function, and inflammation associated with dyslipidemia in rats. The results showed that carnosine supplementation significantly improved total and LDL cholesterol levels in serum, especially when combined with simvastatin. Carnosine also had anti-inflammatory effects and showed a good safety profile in terms of liver and kidney functions.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Dena Nuwaylati, Basmah Eldakhakhny, Abdulhadi Bima, Hussein Sakr, Ayman Elsamanoudy
Summary: Insulin resistance plays a role in the pathogenesis of many diseases, and the ketogenic diet has been proven as an effective treatment for various insulin resistance-related disorders. However, the safety of the ketogenic diet is still debatable, and attention should be given to the opportunities and challenges associated with its implementation.
Article
Biochemistry & Molecular Biology
Lu Lu, Jingming Ren, Tong Yuan, Xinran Lu, Yinping Dong, Wenxuan Li, Xinyue Wang, Qidong Huo, Junling Zhang, Deguan Li, Saijun Fan
Summary: A high-fat diet increases the risk of malignant tumors, while ionizing radiation is used as a treatment in oncology. This study examined the effects of an 8-week high-fat diet on radiation tolerance and the influence of melatonin. The results showed that the high-fat diet altered radiation tolerance in female mice, but not in males. However, pre-treatment with melatonin attenuated radiation-induced damage and affected the composition of gut microbiota and metabolites in both males and females.
Article
Biochemistry & Molecular Biology
Mingming Li, Yang Xiao, Lianggui Xiao, Yu Li, Mengting Jia, Yu Sun, Tingli Pan, Lei Zhou, Yixing Li
Summary: With improvements in living standards, obesity has become an increasingly serious health issue. This study found that epigoitrin (EP) from Radix isatidis has significant potential in preventing and treating obesity. EP reduced fat accumulation, promoted glucose uptake and glycogen storage, increased energy production, and improved lipid and glucose metabolism disorders.
Article
Nutrition & Dietetics
Seo Yeon Lee, Hyun Gyun Yuk, Seong Gyu Ko, Sung-Gook Cho, Gi-Seong Moon
Summary: This study demonstrates that Korean red ginseng inhibits high-fat-diet-induced obesity and diabetes by altering gut microbiome. Both saponin-containing red ginseng extract (SGE) and saponin-depleted red ginseng extract (GE) attenuated the effects of high-fat diet on body weight, food intake, fat weights, plasma glucose, insulin, and leptin levels.
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)