Article
Chemistry, Organic
Yueting Wei, Ping Liu, Yali Liu, Jing He, Xuezhen Li, Shiwu Li, Jixing Zhao
Summary: A new three-component reaction has been developed for the synthesis of 3-aryl-4-(arylthio)-1H-pyrazol-5-amines, with the use of NIS to facilitate sequential cyclization and sulfenylation reactions. The protocol demonstrates broad substrate scope, good functional group tolerance, and mild reaction conditions. Gram-scale synthesis and diverse transformations of the products further highlight the utility of this procedure.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Fathy M. Abdelrazek, Sobhi M. Gomha, Mohamed S. Farghaly, Peter Metz
Summary: Grinding a mixture of specific compounds in the presence of aluminate sulfonic acid nanoparticles under solvent-free conditions resulted in the synthesis of pyrido[2,3-d]pyrimidinone derivatives and ethyl 5-oxo-1-aryl-6,7,8-triphenyl-1,5,6,9-tetrahydropyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-3-carboxylate derivatives. The method offers advantages such as high yields, short reaction time, easy workup, and reusability of the catalyst.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
Chaowei Zhang, Gaoqing Yuan
Summary: A novel and efficient electrochemical synthesis method was reported for the synthesis of 2-aminothiazole derivatives from ketones and NH4SCN. The target product could be obtained in good to excellent yields through the co-action of NH3 and iodine free radicals or electrochemically generated iodine (I-2).
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Mohammad A. Alam
Summary: Recent advances in the synthesis of thiazole compounds using domino/cascade and multicomponent approaches have been summarized in this perspective.
CURRENT ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Chada Raji Reddy, Sana Fatima, Dattahari H. Kolgave, Balasubramanian Sridhar
Summary: An approach for the assembly of phenanthrone derivatives with all carbon quaternary centres has been developed using visible light-promoted tandem sulfonylation/intramolecular-arylation. The synthetic strategy has been extended to include thiotrifluoromethyl and thiocyanato radicals under oxidative conditions. The scalability and versatility of the synthesis were also demonstrated.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Gen Li, Steven P. Miller, Alexander T. Radosevich
Summary: The reported method utilizes an organophosphorus catalyst and hydrosilane to drive the cross-selective intermolecular N-N reductive coupling of nitroarenes and anilines, with good chemoselectivity and functional group tolerance. Mechanistic investigations support an autotandem catalytic reaction cascade involving two sequential reduction events to produce the desired N-N bond.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Shuai Shi, Wenting Qiu, Pannan Miao, Ruining Li, Xianfeng Lin, Zhankui Sun
Summary: The authors expanded the scope of the classical Mannich reaction to enolizable aldehydes by employing a radical process, resulting in a streamlined synthesis of gamma -amino-carbonyl compounds.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Aurapat Ngamnithiporn, Padon Chuentragool, Poonsakdi Ploypradith, Somsak Ruchirawat
Summary: This article reports the development of a novel three-component aza-Diels-Alder reaction, employing sultines, aldehydes, and amines as substrates. By using Cu(OTf)(2) as a Lewis acid catalyst and the in situ generation of imines, a wide range of polysubstituted tetrahydro-isoquinoline derivatives can be easily prepared from readily available precursors. The synthetic utility of these products is demonstrated through various product transformations, including the synthesis of tricyclic N-heterocycles.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Fuhong Xiao, Enbo Yu, Ya Chen, Guo-Jun Deng
Summary: A convenient protocol for the synthesis of thiazole-2-thiones from nitrobenzene, chalcones and carbon disulfide is described in this study. The construction of one C-S bond and two C-N bonds via [3+2] cycloaddition reaction is achieved using NaOH as the base in one pot, with various functional groups attached to substrates well tolerated to afford the corresponding products in moderate to good yields.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Applied
Kai-Kai Wang, Yan-Li Li, Rong-Xiang Chen, Ai-Li Sun, Zhan-Yong Wang, Ying-Chao Zhao, Ming-Yue Wang, Shi Sheng
Summary: The additive-free 1,3-dipolar cycloaddition reaction enables diversity-oriented synthesis of novel and structurally complex derivatives in high yields and excellent diastereoselectivities.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Fatemeh Sadat Hosseininasab, Hamid Reza Memarian
Summary: Various symmetric and asymmetric decahydroacridine-1,8-dione and polyhydroquinoline derivatives were synthesized via two-step cyclocondensation reactions. The step-wise addition of reactants in this method avoids the formation of undesired by-products, leading to a cleaner work up of the reaction.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Organic
Ivan S. Odin, Kareem V. Gordon, Radik N. Itakhunov, Dmitry M. Gusev, Sergey A. Sokov, Anna V. Vologzhanina, Stanislav A. Grabovskiy, Ilya M. Sosnin, Anton I. Ukolov, Olga I. Orlova, Vladimir A. Lazarenko, Pavel V. Dorovatovskii, Darina D. Darmoroz, Anastasiia O. Piven, Tetiana Orlova
Summary: Based on selective reactions, this work presents a common methodology for the synthesis of polysubstituted luminescent derivatives. The synthesis utilizes cross-conjugated enynones as building blocks and involves reactions with hydrazines and their derivatives.
SYNTHESIS-STUTTGART
(2023)
Article
Biochemistry & Molecular Biology
Akram Ranjbar Derranji, Mohammad Anary-Abbasinejad, Marziyeh Mohammadi
Summary: The three-component reaction between trialkyl phosphites, dialkyl acetylenedicarboxylates, and aromatic amines or dinitrophenylhydrazine resulted in the formation of beta-aminoalkylphosphonate derivatives and beta-hydrazinooalkylphosphonate derivatives, respectively. This method allows for the simultaneous formation of C-N and C-P bonds in a single synthetic step under neutral and simple reaction conditions, without the need for a catalyst. The reactions were carried out at room temperature in CH2Cl2 solvent and yielded stable products in high yields. The structures of the products were confirmed by H-1, C-13, and P-31 NMR, IR spectroscopy, and elemental analysis data.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Physical
G. Kanagasabapathy, S. Britto, V. Anbazhagan
Summary: This study presents a new method for synthesizing a series of 2-aminothiazole derivatives by cyclocondensation reaction of thiourea with appropriate acid halides followed by condensation with highly functionalized amines. The synthesized products were characterized and evaluated for their antibacterial and antifungal activity against Bacillus cereus and Candida albicans. In silico analysis demonstrated acceptable binding interactions of the derived products with the active sites of the pathogens.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Gholamhassan Imanzadeh, Samira Zolfagharzadeh, Zahra Soltanzadeh
Summary: A series of new N-alkylated derivatives of N-acylhydrazones have been successfully prepared under solvent-free conditions by utilizing inexpensive base and ionic organic salt media.
LETTERS IN ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Toktam Afrough, Mehdi Bakavoli, Hossein Eshghi, Hamid Beyzaei, Mohammadreza Moghaddam-Manesh
Summary: A new methodology for synthesizing pyrimido[4 ',5':5,6][1,4]thiazino[2,3-b]quinoxaline derivatives was introduced, with the occurrence of S/N type Smiles rearrangement confirmed during the reaction. The newly synthesized compounds were evaluated for potential antibacterial activity, with two showing moderate value compared to three reference drugs.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Article
Chemistry, Organic
Hamid Beyzaei, Farideh Malekraisi, Reza Aryan, Behzad Ghasemi
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
(2020)
Article
Biochemistry & Molecular Biology
Elahe Yarmohammadi, Hamid Beyzaei, Reza Aryan, Ashraf Moradi
Summary: A novel process for synthesizing 5-substituted 1,3,4-oxadiazole-2-thiol derivatives was proposed in this study, demonstrating good to excellent yields and potential antioxidant, antibacterial, and antifungal properties. The synthesized compounds showed broad-spectrum antimicrobial activity and significant antioxidant potential. Additionally, they are potent candidates for treating cancer, Parkinson's disease, inflammatory conditions, and diabetes.
MOLECULAR DIVERSITY
(2021)
Article
Chemistry, Organic
Mohammadreza Moghaddam-manesh, Hamid Beyzaei, Mostafa Heidari Majd, Sara Hosseinzadegan, Kiarash Ghazvini
Summary: The study found that the synthesized heterocyclic compounds containing thiazole core exhibited excellent anticancer, antibacterial, antifungal, and antioxidant activities, suggesting their potential as potent antimicrobial, antioxidant, and anticancer agents. Compound 7 showed higher anticancer and antibacterial properties, while thiazole 5 demonstrated better antioxidant effects.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Abbas Rahdar, Parisa Hasanein, Muhammad Bilal, Hamid Beyzaei, George Z. Kyzas
Summary: Quercetin was formulated into microemulsions to improve bioavailability, with the nanoencapsulated form showing potential in protecting against gentamicin-induced renal oxidative stress and kidney damage in a rat model of nephrotoxicity. Further evaluations are warranted.
Article
Chemistry, Physical
Pouya Ghamari Kargar, Ghodsieh Bagherzade, Hamid Beyzaei
Summary: A novel and green protocol for the synthesis of amides using benzyl alcohols and amines as reactants and Ni-MOF as catalyst was developed. The morphological, structural, and physicochemical characteristics of the Ni-MOF were investigated. The reaction was conducted under ultrasound irradiation in ethanol, resulting in good to excellent yields of the products. Additionally, the low-cost catalyst could be reused multiple times without significant reduction in efficiency.
MOLECULAR CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Mostafa Arab, Hamid Beyzaei, Reza Aryan
Summary: A new one-pot method for the synthesis of 3-amino-1,2,4-triazole derivatives was proposed using choline chloride/urea as a solvent and reagent. This method has the advantages of being eco-friendly, low-cost, and efficient, and the synthesized triazoles showed antimicrobial activity against various bacterial strains.
Article
Chemistry, Multidisciplinary
Roya Maghamifar, Seddigheh Sheikhi-Mohammareh, Hamid Beyzaei, Zahra Ebrahimnezhad, Ali Shiri
Summary: In this study, a variety of 5-bromo-4-methyl-2-substituted pyrimidines with pyrazolyl substituent at C-4 position were synthesized. The products were obtained by treating 5-bromo-4-hydrazineyl-6-methyl-2-substituted pyrimidines and vinamidinum salt. The synthesized products were evaluated for their inhibitory and hydrogen-atom donating abilities against pathogens, showing notable antimicrobial effects for 5-bromo-4-methyl-6-pyrazolylpyrimidine with 2-(4-methylpiperazin) substituent (7e).
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Iman Farzamnezhad, Seddigheh Sheikhi-Mohammareh, Hamid Beyzaei, Elahe Yarmohammadi, Ali Shiri
Summary: A series of novel selenium-containing compounds, 7-cyano-4-imino-3-phenyl-6-(pyrrolidin-1-yl)-2-substituted-3,4-dihydroselenopheno[3,2-d]pyrimidines, were successfully synthesized through a base-promoted cascade addition/cyclization sequence. The synthesized compounds showed promising antioxidant activity, with IC50 values ranging from 12.19 to 91.08 μM. Among the compounds, the unfused 3-amino-2,4-dicyano-5-(pyrrolidin-1-yl)selenophene exhibited higher antioxidant activity than ascorbic acid. The benzylated derivative of the pyrimidine-fused heterocycles showed the best antioxidant activity, suggesting the potential for these compounds to be used as effective anti-cancer, anti-diabetic, anti-inflammatory, and anti-neurodegenerative agents.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Analytical
Seddigheh Sheikhi-Mohammareh, Fatemeh Oroojalian, Hamid Beyzaei, Mohammadreza Moghaddam-Manesh, Alireza Salimi, Fatemeh Azizollahi, Ali Shiri
Summary: An efficient one-pot two-step procedure was established for the synthesis of novel pyrazolo[5,1:2,3']pyrimido[4,5':5,6][1,4]thiazino[2,3-b]quinoxalines from easily accessible starting materials. The synthesized compounds showed significant antioxidant activity and can be used as fluorescent markers and probes in biochemistry and pharmacology studies.
Review
Pharmacology & Pharmacy
Shahla Ranjbar, Abbasali Emamjomeh, Fatemeh Sharifi, Atefeh Zarepour, Kian Aghaabbasi, Ali Dehshahri, Azadeh Mohammadi Sepahvand, Ali Zarrabi, Hamid Beyzaei, Mohammad Mehdi Zahedi, Reza Mohammadinejad
Summary: Herbal chemicals with a long history in medicine, such as flavonolignans and flavonoids, have various therapeutic capabilities. However, their hydrophobic properties limit their bioavailability and application. To overcome this challenge, lipid-based nanocarriers have been introduced to improve the delivery of these compounds, enhancing their bioavailability and reducing side effects.
Article
Chemistry, Multidisciplinary
Sedigheh Damavandi, Fereshteh Shiri, Abbasali Emamjomeh, Somayeh Pirhadi, Hamid Beyzaei
Summary: Lactate dehydrogenase (LDH) is an important enzyme associated with diseases such as cancers, heart disease, liver problems, and corona disease. Proteochemometrics method was applied to model LDHA and LDHB isoenzyme inhibitors using three machine learning algorithms. The best ensemble model showed a correlation coefficient of 0.66 and 0.62 for LDHA and LDHB isoenzyme inhibitors, respectively. The inhibition of LDH activity is influenced by Morgan fingerprints and topological structure descriptors.
Article
Veterinary Sciences
Hamid Beyzaei, Mojtaba Mirzaei, Narjes Hasan Fakhrabadi, Behzad Ghasemi
Summary: New inhibitory agents such as peptides, heterocyclic derivatives, and nanoparticles have shown effectiveness against both standard and drug-resistant strains of microorganisms. Tetrahydropyrimidine derivative 3f exhibited the best inhibitory properties, while synergistic effects were observed when combining nisin with major derivatives for improved antifungal effects.
VETERINARY RESEARCH FORUM
(2021)
Article
Chemistry, Multidisciplinary
Hamid Beyzaei, Soheila Sargazi, Ghodsieh Bagherzade, Ashraf Moradi, Elahe Yarmohammadi
Summary: A method for synthesizing 1,3,4-oxadiazole-2-amines efficiently using ultrasound assistance was proposed in this study. The synthesized compounds exhibited antioxidant properties and potential for treating various diseases.
ACTA CHIMICA SLOVENICA
(2021)
