Review
Plant Sciences
Soojin Oh, Gareth Cave, Chungui Lu
Summary: Developing a resilient food supply is crucial in delivering necessary nutrients to consumers and addressing micronutrient deficiencies that can lead to severe health issues. Therefore, focus should be on enhancing minerals and nutrients in food through various methods to improve the sustainability of the food system.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Multidisciplinary Sciences
Kyly C. Whitfield, Taryn J. Smith, Fabian Rohner, Frank T. Wieringa, Tim J. Green
Summary: Thiamine is essential for energy metabolism and cognitive health, with deficiencies leading to clinical issues and posing a particular risk to infants. LMICs lack mandatory thiamine fortification programs, highlighting the need for increased thiamine intake and addressing knowledge gaps.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Tauqeer Ahmad, Zahid Mehmood, Maazullah Khan, Muhammad Asim Irshad
Summary: Conventional methods for quantifying the added iron in wheat flour are time-consuming and costly. A rapid method (Time/Sample: 95 min) was developed by modifying the conventional standard method (Time/Sample: 560 min) and validated. The rapid method showed excellent linearity, accuracy, and precision, making it a sustainable alternative to conventional methods.
Review
Food Science & Technology
Vaibhav Kumar Maurya, Amita Shakya, Khalid Bashir, Satish Chand Kushwaha, David Julian McClements
Summary: Vitamin A is an essential micronutrient and its deficiency remains a major health concern in many regions. It plays an important role in human health, but the intake in the diet is often below the recommended level and may be degraded during processing and storage. Fortified foods are recommended as a safe and cost-effective solution, but there are challenges to overcome before effective fortified foods can be developed.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Nutrition & Dietetics
He Helen Huang, Alan A. Cohen, Pierrette Gaudreau, Christiane Auray-Blais, David Allard, Michel Boutin, Isabelle Reid, Valerie Turcot, Nancy Presse
Summary: The study found a higher risk of vitamin B-12 deficiency among older adults. Dietary intake of vitamin B-12, especially from dairy sources, was associated with a decreased risk of low vitamin B-12 status and deficiency in older adults. Different food groups may have different contributions to reducing the risk of deficiency in older populations.
JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Odunayo Ifeoluwa Sobowale, Moududur Rahman Khan, Anjan Kumar Roy, Rubhana Raqib, Faruk Ahmed
Summary: This study examines the deficiency of vitamin B-12 in pregnant rural Bangladeshi women and found that the proportions of vitamin B-12 deficiency and marginal deficiency increased as their pregnancies progressed. Gestational age, housing situation, and the frequency of consuming red or organ meat were identified as independent risk factors for vitamin B-12 deficiency in this population.
Article
Biochemistry & Molecular Biology
Luisa Pellegrino, Franca Marangoni, Giovanna Muscogiuri, Paolo D'Incecco, Guillaume T. Duval, Cedric Annweiler, Annamaria Colao
Summary: Vitamin D is crucial for bone health as well as overall health, but its deficiency is common worldwide. Fortifying food such as milk is recommended to address this issue and promote adequate intake of this essential vitamin.
Article
Agriculture, Multidisciplinary
Aoi Yamamoto, Mahiro Seki, Kyohei Koseki, Yukinori Yabuta, Katsuhiko Shimizu, Jiro Arima, Fumio Watanabe, Tomohiro Bito
Summary: This study demonstrates the use of cyanocobalamin to fortify tomato fruits with vitamin B-12, which can help prevent nutritional deficiencies in vegetarians.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Zoology
Mudassir Safdar, Aurang Zeb, Sidra Khalid, Shahid Bashir, Riffat Mehboob, Muhammad Imran
Summary: The study aimed to determine the effect of fortified wheat flour on the hemoglobin level of anemic hostel girls. The results showed that the average hemoglobin level of anemic girls increased from 8.99g/dl to 9.94g/dl after consuming iron fortified chapatti, leading to a significant reduction in the prevalence of anemia.
PAKISTAN JOURNAL OF ZOOLOGY
(2022)
Review
Nutrition & Dietetics
Zhibin Wang, Wei Zhu, Yi Xing, Jianping Jia, Yi Tang
Summary: This meta-analysis suggests that B vitamin supplementation is associated with slowing of cognitive decline, especially in populations who received early intervention and intervention of long duration; the study also indicates that higher intake of dietary folate, but not B12 or B6, is associated with a reduced risk of incident dementia in non-dementia aged population.
Article
Nutrition & Dietetics
Svenja M. Jungjohann, Gulshan Ara, Catia Pedro, Valerie M. Friesen, Mansura Khanam, Tahmeed Ahmed, Lynnette M. Neufeld, Mduduzi N. N. Mbuya
Summary: The study found that vitamin A fortification levels are higher in packaged and branded edible oils in Bangladesh, but lower in bulk, unbranded oils, resulting in the majority of oil volume available to the population being either not fortified or fortified below standard requirements. Regulatory inspections of producers selling bulk oils should be prioritized to ensure all oils are traceable and meet fortification standards.
Article
Surgery
Kirsti K. Bjerkan, Jorunn Sandvik, Siren Nymo, Halvor Graeslie, Gjermund Johnsen, Ronald Marvik, Asne A. Hyldmo, Bard Eirik Kulseng, Sandra Sommerseth, Kjetil Laurits Hoydal, Dag Arne L. Hoff
Summary: Adherence to recommended supplements after Roux-en-Y gastric bypass (RYGB) can reduce the risk of nutrient deficiencies, especially for thiamine, vitamin B-2, vitamin B-6, folate, vitamin B-12, and vitamin D. However, deficiencies may still occur even with supplement adherence.
Article
Food Science & Technology
Sonia Bonacci, Vita Di Stefano, Fabiola Sciacca, Carla Buzzanca, Nino Virzi, Sergio Argento, Maria Grazia Melilli
Summary: This study evaluated the rheological and chemical quality of pasta samples made from durum wheat semolina fortified with hemp seed residue. Results showed that hemp seed residue can be used to produce high-quality, nutritionally rich, low-cost pasta with good color and functionality.
Article
Chemistry, Physical
Verdiana Marchiano, Maria Matos, Esther Serrano, Jose R. Alvarez, Ismael Marcet, M. Carmen Blanco-Lopez, Gemma Gutierrez
Summary: Nanomaterials have shown significant advantages in the production of pharmaceuticals, cosmetics, food, and food packaging. This study focuses on encapsulating vitamin B-12 in nanovesicles and explores the effects of different formulations and processing steps on vesicle characteristics.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Nutrition & Dietetics
Helena Pachon, Bethany Reynolds, Michelle Duong, Becky L. Tsang, Lana Childs, Corey L. Luthringer, Yunhee Kang, Florencia C. Vasta, Karen Codling
Summary: Food fortification is aimed at improving the nutritional profile of diets. The potential nutrient contribution of fortified maize flour, oil, rice, salt, and wheat flour in diets was estimated in 153 countries. Overall, the fortification practices have the global potential to contribute up to 15 nutrients to people's diets with minimal risk of exceeding Tolerable Upper Intake Levels (ULs).
Article
Biochemical Research Methods
Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Fernando J. Corrales, Jochen M. Schwenk, Young-Ki Paik, Jennifer E. Van Eyk, Siqi Liu, Stephen Pennington, Michael P. Snyder, Mark S. Baker, Eric W. Deutsch
JOURNAL OF PROTEOME RESEARCH
(2019)
Article
Biochemical Research Methods
Chengxin Zhang, Lydie Lane, Gilbert S. Omenn, Yang Zhang
JOURNAL OF PROTEOME RESEARCH
(2019)
Review
Biochemical Research Methods
Vera Ignjatovic, Philipp E. Geyer, Krishnan K. Palaniappan, Jessica E. Chaaban, Gilbert S. Omenn, Mark S. Baker, Eric W. Deutsch, Jochen M. Schwenk
JOURNAL OF PROTEOME RESEARCH
(2019)
Article
Biochemical Research Methods
Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Ileana M. Cristea, Fernando J. Corrales, Cecilia Lindskog, Young-Ki Paik, Jennifer E. Van Eyk, Siqi Liu, Stephen R. Pennington, Michael P. Snyder, Mark S. Baker, Nuno Bandeira, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Multidisciplinary Sciences
Michael Wainberg, Andrew T. Magis, John C. Earls, Jennifer C. Lovejoy, Nasa Sinnott-Armstrong, Gilbert S. Omenn, Leroy Hood, Nathan D. Price
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Subash Adhikari, Edouard C. Nice, Eric W. Deutsch, Lydie Lane, Gilbert S. Omenn, Stephen R. Pennington, Young-Ki Paik, Christopher M. Overall, Fernando J. Corrales, Ileana M. Cristea, Jennifer E. Van Eyk, Mathias Uhlen, Cecilia Lindskog, Daniel W. Chan, Amos Bairoch, James C. Waddington, Joshua L. Justice, Joshua LaBaer, Henry Rodriguez, Fuchu He, Markus Kostrzewa, Peipei Ping, Rebekah L. Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fabio C. S. Nogueira, Gilberto B. Domont, Yves Vandenbrouck, Maggie P. Y. Lam, Sara Wennersten, Juan Antonio Vizcaino, Marc Wilkins, Jochen M. Schwenk, Emma Lundberg, Nuno Bandeira, Gyorgy Marko-Varga, Susan T. Weintraub, Charles Pineau, Ulrike Kusebauch, Robert L. Moritz, Seong Beom Ahn, Magnus Palmblad, Michael P. Snyder, Ruedi Aebersold, Mark S. Baker
NATURE COMMUNICATIONS
(2020)
Article
Biochemical Research Methods
Chengxin Zhang, Wei Zheng, Micah Cheng, Gilbert S. Omenn, Peter L. Freddolino, Yang Zhang
Summary: The study utilized deep learning contact-assisted structure prediction to annotate the functions and protein-protein interaction networks of poorly characterized proteins in JCVI-syn3A. The research demonstrated the importance of nutrient uptake even in a minimized genome, and showed that the reconstructed PPI network exhibits characteristics typical of naturally evolved bacterial PPI networks.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Biochemical Research Methods
Gilbert S. Omenn
Summary: The HUPO Human Proteome Project celebrates its 10th anniversary by achieving the milestone of confident detection of proteins from 90% of predicted protein-coding genes. This global project has influenced data-sharing, quality assurance, and issued stringent guidelines for detecting missing proteins. The project's impact is highlighted in special issues of Nature Communications and Journal of Proteome Research.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Article
Biochemistry & Molecular Biology
Xiaoqiang Huang, Robin Pearce, Gilbert S. Omenn, Yang Zhang
Summary: This study identified a set of drugs with positively charged groups that can inhibit the trypsin-like serine protease TMPRSS2, which is involved in the viral entry and spread of coronaviruses like SARS-CoV-2. Molecular docking and dynamics simulations showed strong binding interactions between these drugs and TMPRSS2, suggesting their potential as effective inhibitors for COVID-19 treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemical Research Methods
Eric W. Deutsch, Gilbert S. Omenn, Zhi Sun, Michal Maes, Maria Pernemalm, Krishnan K. Palaniappan, Natasha Letunica, Yves Vandenbrouck, Virginie Brun, Sheng-ce Tao, Xiaobo Yu, Philipp E. Geyer, Vera Ignjatovic, Robert L. Moritz, Jochen M. Schwenk
Summary: The study of proteins circulating in blood presents significant opportunities for diagnosing, stratifying, or preventing diseases. Recent technological advancements have made the proteomic analysis of blood-derived serum and plasma increasingly important in understanding human biology and pathophysiology. By utilizing mass-spectrometry (MS) or affinity-based methods, valuable insights into SARS-CoV-2 infections, aging, and hemostasis have been gained, along with the potential to combine proteomics with genetic data for further insights. The ongoing challenges include translating plasma proteomics into precision medicine, with recent advances in the field providing impactful applications.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemical Research Methods
Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Young-Ki Paik, Ileana M. Cristea, Fernando J. Corrales, Cecilia Lindskog, Susan Weintraub, Michael H. A. Roehrl, Siqi Liu, Nuno Bandeira, Sudhir Srivastava, Yu-Ju Chen, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch
Summary: The 2021 Metrics of the HUPO Human Proteome Project (HPP) reveal significant progress in detecting protein expression in the human genome. The number of missing proteins has decreased, and the utilization of proteomics in biological and clinical research continues to expand and integrate effectively with other omics platforms. This represents a promising advancement in understanding the human proteome and its potential applications in healthcare.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Genetics & Heredity
Yi-Heng Zhu, Chengxin Zhang, Yan Liu, Gilbert S. Omenn, Peter L. Freddolino, Dong-Jun Yu, Yang Zhang
Summary: This study proposes a new method called TripletGO, which deduces GO terms of genes through the integration of four complementary pipelines. Experimental results show that TripletGO achieves significantly better function annotation accuracy compared to the current state-of-the-art approaches.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Biochemical Research Methods
Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Charles Pineau, Nicolle H. Packer, Ileana M. Cristea, Cecilia Lindskog, Susan T. Weintraub, Sandra Orchard, Michael H. A. Roehrl, Edouard Nice, Siqi Liu, Nuno Bandeira, Yu-Ju Chen, Tiannan Guo, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch
Summary: According to the 2022 metrics of the HUPO Human Proteome Project (HPP), protein expression has been detected for 93.2% of the predicted proteins in the human genome. The number of missing proteins has been reduced, indicating experimental progress and reclassification. Proteomics continues to yield significant findings in biological and clinical studies and integrates with other omics platforms.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemical Research Methods
Michael R. Hoopmann, Ulrike Kusebauch, Magnus Palmblad, Nuno Bandeira, David D. Shteynberg, Lingjie He, Bin Xia, Stoyan H. Stoychev, Gilbert S. Omenn, Susan T. Weintraub, Robert L. Moritz
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Biochemical Research Methods
Xiaoqiang Huang, Chengxin Zhang, Robin Pearce, Gilbert S. Omenn, Yang Zhang
JOURNAL OF PROTEOME RESEARCH
(2020)