Article
Biochemistry & Molecular Biology
Yining Liu, Wenyan Chen, Yanli Cen, Xiaodeng Zhao, Zaiping Chen, Yuedong Liang, Zhongfeng Huang, Xiu He, Guanghong Yang
Summary: Anti-tuberculosis drug-induced liver injury (ATB-DILI) is a common adverse event during tuberculosis treatment, but the underlying molecular mechanisms are unclear. This study found that ferroptosis and lipid peroxidation play a role in ATB-DILI. Treatment with anti-TB drugs led to increased lipid peroxidation and reduced antioxidant levels, along with increased expression of ACSL4 and Fe2+ concentration. The study also showed that inhibiting ferroptosis reversed drug-induced liver damage, while inducing ferroptosis exacerbated the damage. Additionally, the study found that the HIF-1 alpha/SLC7A11/GPx4 signaling pathway was inhibited by anti-TB drug treatment. Knockdown of HIF-1 alpha enhanced ferroptotic events and liver damage. These findings provide new insights into the mechanisms of ATB-DILI and suggest potential therapeutic strategies.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Immunology
Weifeng Tang, Jingjing Qin, Yaolong Zhou, Wenqian Wang, Fangzhou Teng, Jiaqi Liu, La Yi, Jie Cui, Xueyi Zhu, Shiyuan Wang, Jingcheng Dong, Ying Wei
Summary: Acupuncture has a long history in China for treating asthma and recent studies have revealed its potential in regulating ferroptosis and airway inflammation. This study found that non-haem Fe2+ levels and lipid peroxidation markers were elevated in an experimental asthma model, while acupuncture treatment reduced inflammation and markers of ferroptosis. The findings suggest that acupuncture may be a potential therapy for attenuating lipid peroxidation and ferroptosis in asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kai Shan, Jiaqi Li, Qin Yang, Kang Chen, Shanshan Zhou, Lingling Jia, Guoling Fu, Yumin Qi, Qizai Wang, Yong Q. Chen
Summary: Ferroptosis caused by polyunsaturated fatty acid (PUFA) peroxidation plays a significant role in the pathogenesis of acute kidney injury (AKI), suggesting that dietary intake of PUFA may pose a risk for individuals susceptible to AKI. However, in addition to ferroptosis, other mechanisms such as inflammation-associated necroptosis and pyroptosis also contribute to different types of AKI. Therefore, further evaluation is needed to understand the role of PUFA in different AKIs, especially & omega;3 PUFA which is commonly consumed as a food supplement.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yunjia Li, Mengchen Qin, Weichao Zhong, Chang Liu, Guanghui Deng, Menghan Yang, Junjie Li, Haixin Ye, Hao Shi, Chaofeng Wu, Haiyan Lin, Yuyao Chen, Shaohui Huang, Chuying Zhou, Zhiping Lv, Lei Gao
Summary: The study indicates the important role of RAGE in alcoholic liver disease (ALD). Deficiency or inhibition of RAGE can alleviate hepatic inflammation and oxidative stress, as well as affect iron metabolism pathways, thereby improving liver injury.
Article
Biochemistry & Molecular Biology
Feng Li, Xiaojuan Zhao, Fengyu Xie, Zixuan Wang, Hong Ding, Wanru Wang, Ruiqing Jiao, Ying Pan, Lingdong Kong
Summary: The study aimed to investigate the role of CARD6 and its upstream regulator in high fructose-induced liver lipid accumulation, as well as the relationship between nuciferine and CARD6. The results showed that high fructose decreased CARD6 expression and increased ASK1 and JNK1/2 phosphorylation, which were attenuated by nuciferine. It was found that CARD6 overexpression blocked high fructose-induced upregulation of ASK1 and JNK1/2 phosphorylation and lipid accumulation in hepatocytes, and CARD6 siRNA reversed the improvement of nuciferine. Mechanistically, high fructose upregulated MIB2 expression by interacting with CARD6 and promoting K48-linked CARD6 polyubiquitination and degradation, while MIB2 siRNA reversed the downregulation of CARD6 and lipid accumulation. Nuciferine reduced MIB2 expression and decreased K48-linked CARD6 polyubiquitination and degradation in the amelioration of high fructose-induced lipid accumulation.
Article
Agriculture, Multidisciplinary
Peng Wang, Xian Zheng, Ronghuan Du, Jinghan Xu, Jing Li, Huaqi Zhang, Xi Liang, Hui Liang
Summary: Increasing evidence suggests that calcium overload triggered by mitochondrial dysfunction plays a critical role in the development of alcoholic liver disease (ALD). This study demonstrates the potential benefits of astaxanthin (AX) in protecting against alcohol-induced liver injury by restoring redox balance and Ca2+ homeostasis in mitochondria.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Lingpeng Xie, Chuying Zhou, Yuting Wu, Xiuqiong Fu, Guoyong Zhang, Xin Han, Shuwen Xie, Guanghong Chen, Honglin Xu, Bo Deng, Bin Liu, Yingchun Zhou, Aimin Li
Summary: The therapeutic efficacy and potential mechanism of action of Wenqingyin (WQY) in sepsis-induced liver injury were investigated in this study. The results demonstrated that WQY attenuated sepsis-mediated liver injury by suppressing ferroptosis in hepatocytes through the activation of Nrf2.
Article
Biochemistry & Molecular Biology
Yajing You, Chenxi Liu, Tiantian Liu, Miaomiao Tian, Nijin Wu, Zhen Yu, Fenglin Zhao, Jianni Qi, Qiang Zhu
Summary: This study reveals the crucial role of FNDC3B in protecting against hepatic steatosis and ferroptosis in response to chronic alcohol consumption. Our findings suggest that FNDC3B could be a potential therapeutic target for ALD.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Microbiology
Hyunna Jung, Sohyeon You, Soo-Im Choi, Chang-Ho Kang, Gun-Hee Kim
Summary: This study found that L. brevis MG5311 can alleviate ethanol-induced liver injury by inhibiting hepatic oxidative stress and promoting lipid metabolism. This suggests that L. brevis MG5311 may be a beneficial probiotic candidate for ameliorating or preventing alcoholic liver disease.
Article
Gastroenterology & Hepatology
Jacinth Wing-Sum Cheu, Derek Lee, Qidong Li, Chi Ching Goh, Macus Hao-Ran Bao, Vincent Wai-Hin Yuen, Misty Shuo Zhang, Chunxue Yang, Cerise Yuen-Ki Chan, Aki Pui-Wah Tse, Grace Fu-Wan Sit, Cindy Xinqi Liu, Irene Oi-Lin Ng, Chun-Ming Wong, Carmen Chak-Lui Wong
Summary: This study identified FSP1 as a potential therapeutic target for hepatocellular carcinoma (HCC). Inhibiting FSP1 induced ferroptosis, enhanced the anti-tumor immune response, and effectively suppressed HCC tumor growth. FSP1 inhibition represents a new therapeutic strategy for HCC.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Trang Nu Huyen Le, Ho-Jung Choi, Hee-Sook Jun
Summary: The study showed that Liriope platyphylla root ethanolic extract (LPE) can reduce body weight gain, liver weight, hepatic lipid accumulation, serum total cholesterol, AST, and ALT levels in high-fat diet-induced obese mice. LPE decreases lipid accumulation by inhibiting lipogenesis and fatty acid uptake.
Article
Food Science & Technology
Xiaoxuan Jing, Nanhai Zhang, Liang Zhao, Jingxuan Zhou, Wei Wu, Liebing Zhang, Feng Zhou
Summary: Evidence has shown that raspberry wines can alleviate alcoholic liver disease (ALD) and have less impact on the liver compared to Chinese liquor.
Article
Biochemistry & Molecular Biology
Inga Staneviciene, Jurgita Sulinskiene, Ilona Sadauskiene, Arunas Liekis, Ausrine Ruzgaite, Rima Naginiene, Dale Baranauskiene, Vaida Simakauskiene, Raulas Krusnauskas, Dale Viezeliene
Summary: Selenium plays a crucial role in maintaining normal brain function and modulating cellular redox status and iron homeostasis. This study investigated the effects of inorganic selenium excess on oxidative stress and iron homeostasis in the brain and liver of mice. The results showed that selenium accumulated in both organs and disrupted iron levels. Selenium also induced oxidative damage in the liver, but its effects on the brain were dose-dependent, with lower doses providing antioxidant activity and higher doses activating catalase expression to maintain lipid peroxidation levels.
Article
Pharmacology & Pharmacy
Fanrong Zhao, Lei Zhang, Menglin Zhang, Jincan Huang, Jun Zhang, Yongsheng Chang
Summary: This study found that FGF9 expression was increased in the livers of diet-induced obese mice, and knockdown exacerbated the fatty liver phenotype while overexpression alleviated hepatic steatosis and improved insulin sensitivity. Mechanistically, FGF9 inhibits genes involved in lipogenesis and increases genes involved in fatty acid oxidation, reducing cellular lipid accumulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Luiza de Paula Dias Moreira, Barbara Nery Enes, Vinicius Parzanini Brilhante de Sao Jose, Renata Celi Lopes Toledo, Luiz Carlos Maia Ladeira, Rodrigo Rezende Cardoso, Vinicius da Silva Duarte, Helen Hermana Miranda Hermsdorff, Frederico Augusto Ribeiro de Barros, Hercia Stampini Duarte Martino
Summary: This study found that the consumption of chia flour and chia oil can improve metabolic disorders in the liver caused by a high-fat and high-fructose diet. Chia intake increased liver antioxidant capacity and decreased liver steatosis and nitric oxide levels. Chia also regulated gene expression related to fatty acid metabolism. However, chia did not show effects on mitigating liver inflammation.
