Article
Food Science & Technology
Urbashi Hazarika, Zoltan Kovacs, Zsanett Bodor, Beata Gosztola
Summary: The study evaluated the influence of different preservation methods on the phytochemicals and organoleptic properties of two French tarragon varieties. Freezing and shade drying retained the highest essential oil content, while oven drying and lyophilization caused the highest loss. Lyophilization significantly changed the volatile composition and led to the appearance of new components. Lyophilization, oven drying at 40 degrees C, and microwave drying at 700 W preserved the total phenolic content and total antioxidant capacity, while oven drying at 60 degrees C had the opposite effect. Freezing, oven drying at 40 degrees C, and lyophilization preserved the original green color of the leaves, while drying at higher temperatures and power resulted in significant color degradation. Each preservation method altered the taste of the leaves according to e-tongue measurements.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Neurosciences
Hamidreza Safari, Gholamreza Anani Sarab, Mohsen Naseri
Summary: This study found that Artemisia dracunculus extract can alleviate EAE symptoms, reduce levels of inflammatory cytokines, and increase serum antioxidant levels, indicating its potential as an adjuvant therapy for multiple sclerosis.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Mohammad Bagher Hassanpouraghdam, Lamia Vojodi Mehrabani, Nahideh Kheirollahi, Amir Soltanbeigi, Leila Khoshmaram
Summary: Salinity is a significant abiotic stressor that affects crop growth and yield. This study investigated the effects of different foliar sprays on tarragon under NaCl salinity conditions. The results showed that foliar spray with graphene improved the K+/Na+ ratio, zinc spray enhanced catalase activity, and both forms of iron and zinc partially alleviated the adverse effects of salinity on tarragon.
Article
Agricultural Engineering
Hasan Mumivand, Amin Ebrahimi, Mohammad Reza Morshedloo, Alireza Shayganfar
Summary: The study aimed to evaluate the effects of water deficit stress on drug yield, essential oil content, and antioxidant enzymes activity in Tarragon. Results showed that water deficit increased essential oil content but decreased essential oil and drug yield, with different genotypes showing varied responses to water deficit stress. Certain accessions were identified as drought-tolerant based on indicators of drought tolerance and essential oil yield assays.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Energy & Fuels
Naciye Kutlu, Aybike Kamiloglu, Tugba Elbir
Summary: This study investigated the ultrasound extraction of bioactive compounds from tarragon using pure water as the solvent. The results showed that ultrasound extraction had high efficiency and energy-saving advantages under optimized conditions. Ethanol and pure water as solvents both yielded good extraction results, while the use of a deep eutectic solvent was not as effective.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Biochemistry & Molecular Biology
Yusuf Can Gercek, Naciye Kutlu, Saffet Celik, Betul Gidik, Sinan Bayram, Nesrin Ecem Bayram
Summary: This study aimed to investigate the extraction ability of deep eutectic solvents (DESs) with different concentrations in obtaining bioactive compounds from tarragon plants. The results showed that DES10 had the highest efficiency in extracting individual phenolics and amino acids, and also yielded higher compared to ethanol and methanol. The total phenolic content, total flavonoid content, and antioxidant activity of DES extracts varied within a certain range. Therefore, the use of these environmentally friendly green solvents can be recommended as an alternative to organic solvents in the extraction process of this important medicinal plant in different areas.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Food Science & Technology
Hiba Zedan, Seyed Masoud Hosseini, Ali Mohammadi
Summary: The study found that adding 6% CH and 60% TEO to yogurt can improve shelf life and consistency, especially in terms of bacterial count and yeast. However, samples containing 2% CH performed the best in sensory evaluation.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Environmental Sciences
Jorid B. Sorli, Alexander C. o. Jensen, Alicja Mortensen, Jozef Szarek, Eleni Chatzigianelli, Claudia A. T. Gutierrez, Nicklas R. Jacobsen, Sarah S. Poulsen, Iosif Hafez, Charis Loizides, George Biskos, Karin S. Hougaard, Ulla Vogel, Niels Hadrup
Summary: This study evaluated the pulmonary toxicity of tungsten by exposing male mice to tungsten particles and found increased genotoxicity at certain exposure levels. However, no adverse effects were observed on body weight, inflammation, or organ pathology. The study suggests that tungsten exhibits non-dose dependent genotoxicity without inflammation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Microbiology
Shahira A. A. Ahmed, Enas E. E. Eltamany, Mohamed S. S. Nafie, Sameh S. S. Elhady, Panagiotis Karanis, Amira B. B. Mokhtar
Summary: This study investigates the toxic activity of Artemisia judaica ethanolic extract (ArEx), phenolic fraction (ArPh), and terpenoid fraction (ArT) against Cryptosporidium parvum oocysts. The results show that ArPh exhibits toxic activity against C. parvum oocysts and demonstrates antioxidant activity.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Food Science & Technology
Mahsa Esmaeili, Ainaz Khodanazary
Summary: The study found that the combination of pectin coating with chitosan and Tarragon essential oil could effectively inhibit bacterial growth and delay quality changes in fish during refrigerated storage. Incorporating essential oils or other biopolymers into edible coatings can reduce bacterial and physicochemical deterioration in seafood.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2021)
Article
Biochemistry & Molecular Biology
Matthew C. Scott, Aleah Bourgeois, Yongmei Yu, David H. Burk, Brenda J. Smith, Z. Elizabeth Floyd
Summary: The study found that PMI5011 and its active compound DMC-2 have the potential to promote bone health by improving osteoblast maturation and activity, potentially protecting the bones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hamid Mohammadi, Negar Khoshi, Saeid Hazrati, Ahmad Aghaee, Mahdieh Falakian, Mansour Ghorbanpour
Summary: Soil salinity is a major limitation for medicinal plants, but little is known about the effects of light intensity on their physiology and phytochemicals. This study investigated the impact of salt stress and light intensity on tarragon plants, showing that salinity reduced plant height, dry weight, relative water content, and chlorophyll content, while low light intensity improved these characteristics. The interaction of salinity (60 mM) and low light intensity increased anthocyanin and chlorophyll contents, and dry weight. Thus, tarragon yield can be improved by moderate salinity and 75% light intensity through increased synthesis of photosynthetic pigments and phenolic compounds.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Medicine, Research & Experimental
B. Vandanmagsar, Y. Yu, C. Simmler, T. N. Dang, P. Kuhn, A. Poulev, D. M. Ribnicky, G. F. Pauli, Z. E. Floyd
Summary: PMI-5011, an extract from Artemisia dracunculus L., has been shown to improve glucose homeostasis and lipid metabolism in obese insulin resistant male mice through activation of the AMPK signaling pathway, which may hold therapeutic potential for treating insulin resistance or type 2 diabetes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Halina Ekiert, Joanna Swiatkowska, Ewa Knut, Pawel Klin, Agnieszka Rzepiela, Michal Tomczyk, Agnieszka Szopa
Summary: Artemisia dracunculus, commonly known as tarragon, has been traditionally used in Asian medicine and is recognized for its medicinal and spice properties. It has diverse pharmacological effects, including anti-inflammatory, analgesic, antioxidant, and anti-tumor activities, making it a valuable resource in both traditional and modern industries. Research on this plant also extends to biotechnological applications such as micro-propagation protocols.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Environmental Sciences
Juana Sanchez-Alarcon, Mirta Milic, Lilia Patricia Bustamante-Montes, Keila Isaac-Olive, Rafael Valencia-Quintana, Ninfa Ramirez-Duran
Summary: The genotoxic potential of mercury and its derivatives remains controversial, with organic mercury compounds being more toxic than inorganic and elemental ones but all still posing a potential risk. There is not sufficient evidence for mercury to be classified as a human carcinogen. Studies have shown that inorganic mercury compounds such as mercury chloride and mercury nitrate, and organic compounds like methylmercury and thimerosal, are widely studied in populations with accidental, occupational, or iatrogenic exposure.
Review
Pharmacology & Pharmacy
Arpad Tosaki
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Medicine, General & Internal
Nora Lampe, Daniel Priksz, Tamas Erdei, Mariann Bombicz, Rita Kiss, Balazs Varga, Judit Zsuga, Tamas Szerafin, Zoltan Csanadi, Gyorgy Balla, Jozsef Balla, Zoltan Szilvassy, Rudolf Gesztelyi, Bela Juhasz
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Donald David Haines, Arpad Tosaki
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Petra Arany, Ildiko Papp, Marianna Zichar, Mate Csontos, Janos Elek, Geza Regdon, Istvan Budai, Monika Beres, Rudolf Gesztelyi, Palma Feher, Zoltan Ujhelyi, Gabor Vasvari, Adam Haimhoffer, Ferenc Fenyvesi, Judit Varadi, Vecsernyes Miklos, Ildiko Bacskay
Article
Biochemistry & Molecular Biology
Alexandra Gyongyosi, Vivien Verner, Ilona Bereczki, Attila Kiss-Szikszai, Rita Zilinyi, Arpad Tosaki, Istvan Bak, Aniko Borbas, Pal Herczegh, Istvan Lekli
Summary: The newly designed H2S-releasing ibuprofen derivative EV-34 is stable under oxidative conditions, exhibits anti-inflammatory properties, and shows no cytotoxic effects.
Article
Cell Biology
Renata Szabo, Alexandra Hoffmann, Denise Borzsei, Krisztina Kupai, Medea Veszelka, Aniko Magyarine Berko, Imre Pavo, Rudolf Gesztelyi, Bela Juhasz, Zsolt Turcsan, Aniko Posa, Csaba Varga
Summary: The study suggests that HRT has a positive impact on cardiovascular aging, improving oxidative damage and cardiovascular dysfunction.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Annamaria Nagy, David Petho, Rudolf Gesztelyi, Bela Juhasz, Gyorgy Balla, Zoltan Szilvassy, Jozsef Balla, Tamas Gall
Summary: The study demonstrates that BGP-15 can effectively inhibit vascular smooth muscle cell calcification induced by high phosphate levels, preventing osteochondrogenic phenotypic switch and mineralization, as well as deposition of calcium in the extracellular matrix.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Brigitta Tele-Heri, Karoly Dobos, Szilvia Harsanyi, Judit Palinkas, Fanni Fenyosi, Rudolf Gesztelyi, Csaba E. More, Judit Zsuga
Summary: This paper discusses the role of vestibular stimulation in driving multisensory and sensorimotor integration, as well as how motor development may shape the receptive field of multisensory neurons. It also proposes a hypothesis explaining the beneficial effect of sensory integration therapies on attentional processes. Sensorimotor integration therapy, such as TSMT, utilizes specific tools and instruments to increase vestibular and postural stimulation, facilitating sensory-motor integration and muscle strength.
Article
Cell Biology
Renata Szabo, Denise Borzsei, Alexandra Hoffmann, Zelma Nadin Lesi, Rudolf Gesztelyi, Bela Juhasz, Gabor J. Szebeni, Jasmin Osman, Judith Sebestyen, Arnold Nagy, Sandor Szegedi, Csaba Varga, Aniko Posa
Summary: The development and progression of hypertension are closely related to an unhealthy lifestyle, with diet and exercise impacting the physiological mechanisms involved. High-fat and fructose-enriched diets exacerbate hypertension, while exercise has a positive effect on its progression.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Pharmacology & Pharmacy
Mate Kozma, Mariann Bombicz, Balazs Varga, Daniel Priksz, Rudolf Gesztelyi, Vera Tarjanyi, Rita Kiss, Reka Szekeres, Barbara Takacs, Akos Menes, Jozsef Balla, Gyorgy Balla, Judit Szilvassy, Zoltan Szilvassy, Bela Juhasz
Summary: Impaired mitochondrial function is associated with metabolic diseases and cardiovascular diseases. The BGP-15 derivative of vitamin B3 shows therapeutic potential in improving cardiac function and protecting mitochondrial respiration.
Article
Biochemistry & Molecular Biology
Renata Szabo, Zsuzsanna Szabo, Denise Boerzsei, Alexandra Hoffmann, Zelma Nadin Lesi, Patricia Palszabo, Andrea Palszabo, Szabolcs Dvoracsko, Rudolf Gesztelyi, Krisztina Kupai, Daniel Priksz, Bela Juhasz, Anita Altmayer, Csaba Varga, Aniko Posa
Summary: This study aimed to investigate the effects of the endocannabinoid system on cardiac inflammation and oxidative damage. The results showed that the CB1 receptor blocker rimonabant can improve the pathological features of aging heart by enhancing antioxidant defense mechanisms and alleviating inflammatory response.
Article
Biochemistry & Molecular Biology
Evelin Csepanyi, Alexandra Gyongyosi, Istvan Lekli, Arpad Tosaki, Istvan Bak
Summary: This study suggests that beta-carotene may become pro-oxidant under severe oxidative conditions, potentially enhanced by the presence of iron. The use of an iron-chelator can reverse the pro-oxidant effects of beta-carotene and reduce cardiac injury caused by ischemia/reperfusion.
Article
Environmental Sciences
Zsanett Blaga, Peter Czine, Barbara Takacs, Anna Szilagyi, Reka Szekeres, Zita Wachal, Csaba Hegedus, Gyula Buchholcz, Balazs Varga, Daniel Priksz, Mariann Bombicz, Adrienn Monika Szabo, Rita Kiss, Rudolf Gesztelyi, Dana Diana Romanescu, Zoltan Szabo, Miklos Szucs, Peter Balogh, Zoltan Szilvassy, Bela Juhasz
Summary: The study investigates the preferences of residents in Hungary's second-largest city for COVID-19 vaccines. The results indicate that the vaccine with a Chinese country of origin is the least preferred, while the Hungarian and European vaccines are the most preferred. The findings could contribute to increasing compliance among the vaccination-rejecting population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Virag Vass, Erzsebet Szabo, Ilona Bereczki, Nora Debreczeni, Aniko Borbas, Pal Herczegh, Arpad Tosaki
Summary: This study aimed to synthesize a newly designed H2S-releasing ibuprofen derivative, BM-88, and investigate its pharmacological characterization in isolated rat hearts. In vitro experiments showed that preadministration of 10μM BM-88 significantly reduced the incidence of reperfusion-induced ventricular fibrillation (VF), but there was no clear dose dependent reduction. Furthermore, 10μM BM-88 provided substantial protection and reduced the infarct size in the ischemic/reperfused myocardium, without significant changes in coronary flow and heart rates.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Kitti Szoke, Beata Bodi, Zoltan Hendrik, Attila Czompa, Alexandra Gyongyosi, Donald David Haines, Zoltan Papp, Arpad Tosaki, Istvan Lekli
Summary: Previous investigations have shown that rapamycin treatment can increase autophagy levels and suppress the emergence of senescent cells, which are the primary drivers of age-associated physical decline. This study tested the hypothesis that rapamycin treatment in old mice would lead to increased survival, enhanced expression of autophagic proteins, and suppressed inflammation. The results showed that rapamycin-treated mice had improved survival, increased autophagy, elevated expression of klotho protein, and suppressed levels of inflammatory mediators.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)