Article
Multidisciplinary Sciences
Steve Harakeh, Yousef Qari, Hanaa Tashkandi, Mohammed Almuhayawi, Saber H. Saber, Emad Aljahdali, Nagla El-Shitany, Soad Shaker, Filipa Lucas, Turki Alamri, Soad Al-Jaouni, Shaker Mousa
Summary: This study evaluated the protective effects of a novel nanoparticle encapsulating thymoquinone (THY) against cisplatin (CISP)-induced nephrotoxicity. The results showed that NP THY effectively prevented kidney toxicity, improved kidney function and pathology. It also ameliorated oxidative stress conditions and reduced inflammation induced by CISP in the kidney tissue.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Environmental Sciences
Heba El-Sayed Mostafa, Eman Ahmed Alaa El-Din, Dalia Abdallah El-Shafei, Nehal S. Abouhashem, Aisha Abdallah Abouhashem
Summary: This study aimed to investigate the nephrotoxicity of manganese and the potential protective effects of thymoquinone and vildagliptin. Results showed that co-administration of thymoquinone and vildagliptin significantly decreased manganese toxicity, improved inflammation and oxidative stress, and protected the kidneys from damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Kranti A. Mapuskar, Emily J. Steinbach, Amira Zaher, Dennis P. Riley, Robert A. Beardsley, Jeffery L. Keene, Jon T. Holmlund, Carryn M. Anderson, Diana Zepeda-Orozco, John M. Buatti, Douglas R. Spitz, Bryan G. Allen
Summary: Cisplatin is a widely used chemotherapy agent with potent anti-tumor activity, but it can cause renal injuries, leading to the need for intervention strategies to reduce kidney damage. In addition to DNA cross-linking, cisplatin affects mitochondrial metabolism, resulting in reactive oxygen species production and renal damage. Mitochondrial superoxide dismutase mimetics show potential in preventing platinum-associated nephrotoxicity.
Article
Medicine, Research & Experimental
Edmone Dewaeles, Kevin Carvalho, Sandy Fellah, Jaewon Sim, Nihad Boukrout, Raphaelle Caillierez, Hariharan Ramakrishnan, Cynthia Van der Hauwaert, Jhenkruthi Vijaya Shankara, Nathalie Martin, Noura Massri, Agathe Launay, Joseph K. Folger, Clementine de Schutter, Romain Larrue, Ingrid Loison, Marine Goujon, Matthieu Jung, Stephanie Le Gras, Victoria Gomez-Murcia, Emilie Faivre, Julie Lemaire, Anne Garat, Nicolas Beauval, Patrice Maboudou, Viviane Gnemmi, Jean-Baptiste Gibier, Luc Buee, Corinne Abbadie, Francois Glowacki, Nicolas Pottier, Michael Perrais, Rodrigo A. Cunha, Jean-Sebastien Annicotte, Geoffroy Laumet, David Blum, Christelle Cauffiez
Summary: This study demonstrates that istradefylline can protect mice from cisplatin-induced nephrotoxicity and neuropathic pain without compromising the antitumoral properties of cisplatin. Therefore, istradefylline may serve as a valuable preventive approach for the clinical management of patients undergoing cisplatin treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Oncology
Xiaoru Hu, Zhengwei Ma, Lu Wen, Siyao Li, Zheng Dong
Summary: Cisplatin is a commonly used chemotherapy drug, but its efficacy is limited by nephrotoxicity. Autophagy plays a protective role in preventing kidney injury during cisplatin exposure, but may also hinder chemotherapy efficacy by protecting cancer cells. Targeting autophagy presents both therapeutic advances and challenges in improving cisplatin chemotherapy outcomes.
Article
Pharmacology & Pharmacy
Ning Ma, Zhentong Wei, Jianqiang Hu, Wenjing Gu, Xinxin Ci
Summary: The study demonstrated that farrerol effectively inhibited cisplatin-induced inflammation and renal fibrosis by activating Nrf2 and PINK1/Parkin-mediated mitophagy, providing a potential novel therapeutic target for CKD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qingyu Zhou, James D. Quirk, Ying Hu, Huimin Yan, Joseph P. Gaut, Christine T. N. Pham, Samuel A. Wickline, Hua Pan
Summary: Researchers have discovered that using rapamycin-loaded perfluorocarbon nanoparticles (PFC NP) can effectively deliver the drug to the injured kidneys, mitigating cisplatin-induced acute kidney injury and preserving renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Binbin Cui, Xiying Hou, Mengjun Liu, Qing Li, Chao Yu, Shenglei Zhang, Yi Wang, Jun Wang, Shougang Zhuang, Feng Liu
Summary: This study reveals that SMYD2 plays a critical role in cisplatin-induced acute kidney injury. The specific inhibitor AZ505 suppresses SMYD2 expression, improving kidney function and reducing kidney damage. AZ505 exerts its protective effects through mechanisms including reducing cell injury and apoptosis, inhibiting inflammation, and promoting cell proliferation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Hilal Alkis, Elif Demir, Mehmet Resit Taysi, Suleyman Sagir, Seyithan Taysi
Summary: Ionizing radiation leads to the release of free radicals into the systemic circulation, causing oxidative stress in distant organs. Naturally occurring antioxidant agents such as Nigella sativa oil (NSO) and thymoquinone (TQ) exhibit protective and antioxidant effects against oxidative damage in the kidney tissue of rats exposed to cranial irradiation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Erkin Aydin, Aysun Cebeci, Ayca Lekesizcan
Summary: This study developed chitosan/siRNA nanoparticles that effectively reduced cisplatin-induced nephrotoxicity, providing significant protection to the kidneys.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Martina Perse
Summary: The paper summarizes the use of cisplatin in mouse models and existing issues, as well as recommendations for improvements in future research, emphasizing the similarities in response to cisplatin treatment between humans and mice.
Review
Biochemistry & Molecular Biology
Md Abdul Hannan, Md Sarwar Zahan, Partha Protim Sarker, Akhi Moni, Hunjoo Ha, Md Jamal Uddin
Summary: Black cumin and its vital compound, thymoquinone, have shown protective effects against kidney injury caused by various xenobiotics through antioxidation, anti-inflammation, anti-apoptosis, and antifibrosis mechanisms. Clinical trials have demonstrated improvements in blood and urine parameters in advanced CKD patients. However, further research is needed to explore targeted delivery mechanisms and to gather more clinical evidence for recommending black cumin to CKD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Siyao Li, Lu Wen, Xiaoru Hu, Qingqing Wei, Zheng Dong
Summary: Cisplatin, a commonly used chemotherapy drug, is limited by its nephrotoxicity, but hypoxia-inducible factor (HIF) activation may protect against kidney injury during cisplatin chemotherapy. While HIF activation has been shown to have beneficial effects in experimental models of acute kidney injury caused by cisplatin, more research is needed on its effects in chronic kidney problems following cisplatin treatment. Prolyl hydroxylase (PHD) inhibitors, which induce HIF, may offer promise in protecting kidneys during cisplatin chemotherapy, but their potential impact on the anti-cancer effects of cisplatin needs further investigation.
Article
Biochemistry & Molecular Biology
Alfredo G. Casanova, Marta Prieto, Clara I. Colino, Carmen Gutierrez-Millan, Barbara Ruszkowska-Ciastek, Esther de Paz, Angel Martin, Ana I. Morales, Francisco J. Lopez-Hernandez
Summary: This study demonstrated that a micellar formulation of Pluronic F127-encapsulated quercetin (P-quercetin) was more effective in increasing the bioavailability of quercetin and protecting the kidneys in rats when compared to natural quercetin. P-quercetin not only reduced plasma creatinine and urea levels induced by the nephrotoxic drug cisplatin, but also improved some renal function parameters. The new formulation with enhanced properties can potentially lead to the development of quercetin as a nephroprotective agent in clinical settings at lower dosages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Keizo Fukushima, Azusa Futatsugi, Maiko Maekawa, Saya Naito, Akira Okada, Nobuyuki Sugioka
Summary: This study compared the nephrotoxicity of a split dose of cisplatin (CDDP) with the conventional single dose in rats. It found that the split-dose group had significantly lower acute kidney injury (AKI) compared to the single-dose group, suggesting that a split-dose regimen could be an alternative strategy for CDDP-ineligible patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hasan Gencoglu
Summary: This study evaluated the effects of Maca root extract on insulin, IRS1, leptin, and SIRT1 in normal and high-fat diet fed rats. The results showed that Maca reduced insulin levels in fat tissue and liver, increased IRS1 levels in fat tissue, and increased SIRT1 levels. This suggests that Maca has protective and regulatory effects when consumed with a normal or high-fat diet.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Cemal Orhan, Mehmet Tuzcu, Patrick Brice Deeh Defo, Nurhan Sahin, Sara Perez Ojalvo, Sarah Sylla, James R. Komorowski, Kazim Sahin
Summary: The study compared the effects of MgPic and MgO on metabolic and cognitive functions in high-fat diet rats, finding that MgPic had more significant effects in improving these functions.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Betul Demir, Demet Cicek, Cemal Orhan, Besir Er, Fusun Erten, Mehmet Tuzcu, Ibrahim Hanifi Ozercan, Nurhan Sahin, James Komorowski, Sara Perez Ojalvo, Sarah Sylla, Kazim Sahin
Summary: The combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) can promote hair growth by regulating various signaling pathways, while having no effect on nail growth.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Pinar Oner, Besir Er, Cemal Orhan, Kazim Sahin
Summary: Sepsis is associated with systemic inflammation and oxidative stress, leading to organ dysfunction. This study investigated the therapeutic effects of ZnSePO on LPS-GalN-induced septic lung injury, showing that ZnSePO can reduce inflammation and improve survival rates.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kazim Sahin, Cemal Orhan, Oguzhan Ozdemir, Mehmet Tuzcu, Nurhan Sahin, Sara Perez Ojalvo, James R. Komorowski
Summary: This study aimed to examine the impact of different doses of whey protein and amylopectin/chromium complex on muscle protein synthesis, amino acid and insulin levels, and the mTOR signaling pathway in exercised rats. The results showed that rats that received 3.1 g/kg of whey protein combined with chromium complex exhibited a significant increase in muscle protein synthesis. Additionally, the combination of whey protein and chromium complex had beneficial effects on insulin levels and the mTOR signaling pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Nutrition & Dietetics
Oguzhan Ozdemir, Fusun Erten, Besir Er, Cemal Orhan, James R. Komorowski, Sarah Sylla, Sara Perez Ojalvo, Kazim Sahin
Summary: A combination of amylopectin/chromium complex and pea/rice protein can significantly enhance muscle protein synthesis, increase insulin and musclin levels, and activate the mTOR pathway. These findings suggest that the combination of amylopectin/chromium complex and pea/rice protein can be an alternative for muscle remodeling and repair after exercise.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Emre Sahin, Cemal Orhan, Fusun Erten, Zainulabedin Saiyed, Elnaz Karimian Azari, Shane Durkee, Kazim Sahin
Summary: This study investigated the effects of different doses of undenatured type II collagen (UC-II) on improving monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in young and old rats. The results showed that all doses of undenatured collagen reduced knee diameter, while the higher doses (1.33 mg/kg and 2 mg/kg) improved Mankin score and gait measurements as early as day 14. The 2 mg/kg dose showed the best efficacy in improving Mankin score and gait measurements by 28 days post-OA induction. Undenatured collagen also reduced inflammatory and cartilage breakdown markers in both age groups.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Kazim Sahin, Emre Sahin, Patrick B. D. Deeh, Veysi Kayri, Cemal Orhan, Nurhan Sahin
Summary: The main stress factors that disrupt homoeostasis in poultry are environmental, nutritional, microbiological, and managing. Among these factors, high ambient temperatures have a significant impact on poultry production and health. High temperatures lead to oxidative stress and damage the antioxidant capacity of poultry. Nutrients such as vitamins E and C, selenium, and curcumin play a crucial role in enhancing the antioxidant defence system and mitigating the detrimental effects of heat stress.
WORLDS POULTRY SCIENCE JOURNAL
(2023)
Article
Food Science & Technology
Emrah Yazici, Emre Sahin, Nurhan Sahin, Mehmet Tuzcu, Kazim Sahin, Cemal Orhan
Summary: Mango ginger extract has potential antidiabetic effects by reducing serum glucose, insulin, free fatty acid, cholesterol, and triglyceride levels, increasing total antioxidant capacity, and decreasing malondialdehyde levels. It can also alleviate hepatocellular fat accumulation and promote the upregulation of heme oxygenase 1 in the liver through the regulation of GSK-3 beta/Fyn/Nrf2 signaling pathway.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Cemal Orhan, Emre Sahin, Mehmet Tuzcu, Nurhan Sahin, Abdullah Celik, Sara Perez Ojalvo, Sarah Sylla, James R. Komorowski, Kazim Sahin
Summary: The combination of NR and PC can improve inflammatory and antioxidant status in rats under chronic stress conditions by enhancing antioxidant enzyme activities and NAD+ levels.
Article
Medicine, General & Internal
Emre Sahin, Cemal Orhan, Fusun Erten, Fikrettin Sahin, Nurhan Sahin, Kazim Sahin
Summary: This study aimed to investigate the effects of different boron derivatives on nutrient digestibility, intestinal nutrient transporters, and lipid metabolism in rats. The results showed that supplementation of boric acid and sodium pentaborate pentahydrate improved nutrient digestibility, increased the expression levels of intestinal glucose transporters and fatty acid transport proteins, and modulated liver lipid metabolism. These findings are important for promoting intestinal health and maintaining a healthy lifestyle.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dilsad Sezgin, Gulnur Aslan, Kazim Sahin, Mehmet Tuzcu, Necip Ilhan, Engin Sahna
Summary: The aim of this study was to investigate the effects of melatonin on endothelial function and inflammation in hypercholesterolemic rats. The results showed that melatonin could restore the abnormal expressions caused by hypercholesterolemia, thus having protective and therapeutic effects.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Kazim Sahin, Cemal Orhan, Osman Kucuk, Mehmet Tuzcu, Nurhan Sahin, Ibrahim H. Ozercan, Sarah Sylla, Sara P. Ojalvo, James R. Komorowski
Summary: This study aimed to investigate the effects of organic minerals on the blood metabolites, oxidative enzymes, reproductive hormones, and glucose and lipid metabolism-related protein expressions in rats fed a high-fat diet. The results showed that supplementing each organic mineral, especially the combination of HFD + MgPic + ZnPic + SeMet, reversed the negative effects caused by the high-fat diet.
FOOD CHEMISTRY: MOLECULAR SCIENCES
(2022)
