Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 50, Issue 8, Pages 2591-2597Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2012.05.045
Keywords
Parkinson's disease; Salidroside; MPP+; PC12 cells; Apoptosis; PI3K/Akt signaling pathway
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Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). Salidroside (SAL), a phenylpropanoid glycoside isolated from Rhodiola rosea L, can exert potent antioxidant properties. In this study, we investigated the protective effects, and the possible mechanism of action, of SAL against 1-methyl-4-phenylpyridinium (MPP+)-induced cell damage in rat adrenal pheochromocytoma PC12 cells. Pretreatment of PC12 cells with SAL significantly reduced the ability of MPP+ to induce apoptosis in a dose and time-dependent manner. SAL significantly and dose-dependently inhibited MPP+-induced chromatin condensation and MPP+-induced release of lactate dehydrogenase by PC12 cells. SAL enhanced Akt phosphorylation in PC12 cells, and the protective effects of SAL against MPP+-induced apoptosis were abolished by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) phosphorylation. These findings suggest that SAL prevents MPP+-induced apoptosis in PC12 cells, at least in part through activation of the PI3K/Akt pathway. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
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