Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Environmental Sciences
Chunyan Yao, Xiaoling Liu, Yan Tang, Chunmei Wang, Chenggang Duan, Xiaoyan Liu, Mingliang Chen, Yumeng Zhou, Enjie Tang, Ying Xiang, Yafei Li, Ailing Ji, Tongjian Cai
Summary: Microglia-mediated neuroinflammation is crucial in the pathophysiology of neurodegenerative diseases. Lipopolysaccharide (LPS) can activate microglia and induce inflammation. Matrix metalloproteinases (MMPs) and CD147 are key factors involved in microglial activation and inflammation. This study found that CD147 expression was induced in LPS-induced microglial activation, and inhibiting CD147 expression could suppress microglial activation. Furthermore, MMPs and autophagy were involved in the inflammatory activation of microglia, and inhibiting MMPs or autophagy could attenuate this activation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Neurosciences
Sijie Li, Wenbo Zhao, Guiyou Liu, Changhong Ren, Ran Meng, Yuan Wang, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji
Summary: Chronic remote ischemic conditioning (RIC) appears to be well-tolerated and associated with a low annual risk of ischemic stroke and cardio-cerebrovascular events in patients with symptomatic internal carotid artery or middle cerebral artery occlusion with impaired hemodynamics.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Chun-Wei Wu, Jia-Jin Chen, Chou-Ching K. Lin, Chien-An Chen, Chun-Ie Wu, Ing-Shiou Hwang, Tsung-Hsun Hsieh, Bor-Shing Lin, Chih-Wei Peng
Summary: This study investigated the changes in brain tissue optical properties using frequency-domain near-infrared spectroscopy (FD-NIRS) and established the relationship between cerebral hemodynamics and infarct variation in a middle cerebral artery occlusion (MCAO) model. The results suggest that FD-NIRS parameters may be associated with the severity of the infarction and subsequent pathologies in MCAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuelin Zhao, Xiaohua Shi, Jiaoqi Wang, Jing Mang, Zhongxin Xu
Summary: The study found that betulinic acid can reduce cerebral injury by decreasing oxidative stress, as well as activate the SIRT1/FoxO1 pathway to suppress autophagy and improve cerebral injury.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Cell Biology
Li-Dong Deng, Lin Qi, Qian Suo, Sheng-Ju Wu, Muyassar Mamtilahun, Ru-Bing Shi, Ze Liu, Jun-Feng Sun, Yao-Hui Tang, Zhi-Jun Zhang, Guo-Yuan Yang, Ji-Xian Wang
Summary: Transcranial focused ultrasound stimulation attenuated BBB disruption and edema formation in acute ischemic stroke, improving neurobehavioral outcomes and BBB integrity. This may provide a new direction for the treatment of ischemic brain diseases.
NEURAL REGENERATION RESEARCH
(2022)
Article
Clinical Neurology
Andrea Naldi, Alessandra Di Liberto, Enrica Duc, Alessandro Rapellino, Giacomo Paolo Vaudano, Roberto Cavallo, Andrea Boghi
Summary: Bilateral simultaneous middle cerebral artery occlusion is a rare condition that requires rapid intervention for restoring brain perfusion. Perfusion-computed tomography is essential for selecting stroke patients for mechanical thrombectomy, but its role in guiding the optimal treatment strategy for concomitant multivessel cerebral occlusion has not been reported before. This case study highlights the importance of perfusion-computed tomography in both guiding endovascular procedures and planning the sequence of mechanical thrombectomies for bilateral middle cerebral artery occlusion.
NEUROLOGICAL SCIENCES
(2021)
Article
Immunology
Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Zhenhua Zhou, Jiping Tang, Benyan Luo, John H. Zhang
Summary: Activation of TGR5 mitigates brain injury by inhibiting neuroinflammation after MCAO, potentially mediated by Pellino3 inhibition of caspase-8/NLRP3.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Jingsi Xu, Zheyu Zhang, Bo Jin, Yu Geng, Longting Lin, Sheng Zhang
Summary: This study aimed to determine whether baseline delayed filling of the superficial middle cerebral vein (SMCV) was an independent cause of stroke prognosis in patients with acute anterior large vessel occlusion (LVO). The results showed a significant association between baseline delayed SMCV and a 3-month poor outcome, while SMCV reversal did not significantly change the stroke prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Lang Zeng, Shengqi Hu, Lingcheng Zeng, Rudong Chen, Hua Li, Jiasheng Yu, Hongkuan Yang
Summary: Ischemic stroke is a common type of stroke that has a significant impact on human well-being and quality of life. To better understand the pathophysiology of ischemic stroke and develop new treatment strategies, controllable and consistent animal models are urgently needed. The middle cerebral artery occlusion (MCAO) model is currently the most widely used model for studying ischemic stroke. This review discusses different methods for constructing the MCAO model and compares their advantages and disadvantages, aiming to provide better approaches for studying ischemic stroke.
Review
Clinical Neurology
Jennifer D. Sokolowski, Sauson Soldozy, Khadijeh A. Sharifi, Pedro Norat, Kathryn N. Kearns, Lei Liu, Ashley M. Williams, Kaan Yagmurlu, Panagiotis Mastorakos, G. Wilson Miller, M. Yashar S. Kalani, Min S. Park, Ryan T. Kellogg, Petr Tvrdik
Summary: Stroke is a major burden, and despite advances in prevention and treatment, it still negatively affects patients, families, and healthcare professionals. Preclinical basic research, particularly using mouse models, can help to understand stroke pathology and discover effective interventions. This article reviews the middle cerebral artery occlusion technique and introduces various imaging approaches to enhance preclinical stroke evaluation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Alexandre Bani-Sadr, Laura Mechtouff, Charles De Bourguignon, Aela Mauffrey, Timothe Boutelier, Tae-Hee Cho, Matteo Cappucci, Roxana Ameli, Marc Hermier, Laurent Derex, Norbert Nighoghossian, Yves Berthezene
Summary: This study aimed to investigate the relationship between baseline blood-brain barrier (BBB) permeability and the kinetics of circulating inflammatory markers in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy. It was found that increased BBB permeability was associated with a larger ischemic core and higher levels of inflammatory markers. In patients with symptom onset <6 hours, increased BBB permeability was also associated with higher MMP-9 levels.
Article
Biochemistry & Molecular Biology
Mikhail V. Onufriev, Yulia V. Moiseeva, Marina Y. Zhanina, Natalia A. Lazareva, Natalia V. Gulyaeva
Summary: A direct comparison between rat MCAO-KM and MCAO-LM models showed similar outcomes in terms of infarct volume, mortality rate, neurological deficit, and weight loss three days after MCAO induction, but significant differences were observed in corticosterone and interleukin-1 beta release as well as hippocampal accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michael Bieber, Michael K. Schuhmann, Maximilian Bellut, David Stegner, Katrin G. Heinze, Mirko Pham, Bernhard Nieswandt, Guido Stoll
Summary: This study demonstrates that combining neuroprotective and anti-platelet interventions can enhance therapeutic effects in patients with ischemic stroke, providing new insights for the clinical treatment of hyper-acute stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Xiangjun Xu, Ke Yang, Junfeng Xu, Qian Yang, Yapeng Guo, Youqing Xu, Hao Wang, Liang Ge, Zhiming Zhou, Xianjun Huang
Summary: This study aimed to evaluate the differences in endovascular treatment outcomes among MCAO patients with different pathologic subtypes. The results showed that patients with different etiologies had comparable successful recanalization rates and functional independence at 90 days.
