Article
Nutrition & Dietetics
Bi Luo, Jia Lv, Kejie Li, Peiran Liao, Peng Chen
Summary: This study successfully extracted a new polysaccharide K-CMLP from Citrus medica L. var. sarcodactylis and analyzed its structure and bioactivities. The results showed that K-CMLP exhibited strong free-radical-scavenging properties and inhibited the production of pro-inflammatory cytokines and reactive oxygen species.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemical Research Methods
Jie Chen, Nengxin He, Qinyuan Wang, Guang Wu, Wenxia Wu, Qiang Xin, Guangyu Cheng, Zhipei Sang, Caiqing Zhu, Yongzhong Wu, Rongrui Wei, Qinge Ma
Summary: This paper provides a review and analysis of the different extraction methods and multiple bioactivities of diverse flavonoids in C. medica, and discusses their structure-activity relationships. This review may serve as a valuable reference for researching and exploiting C. medica.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Review
Food Science & Technology
Yue Wang, Xiao-Juan Liu, Jie-Biao Chen, Jin-Ping Cao, Xian Li, Chong-De Sun
Summary: This review summarizes the biosynthesis, composition, and distribution of citrus flavonoids, and compares the detection methods of their antioxidant capacity. It also discusses the antioxidant functions of citrus flavonoids under different evaluation systems and their regulatory mechanisms. Additionally, the review points out some shortcomings in current research and provides suggestions for further studies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Oussama Bekkouch, Gokhan Zengin, Mohamed Harnafi, Ilham Touiss, Amine Khoulati, Ennouamane Saalaoui, Hicham Harnafi, Magda H. Abdellattif, Souliman Amrani
Summary: Ginger and lemon juices were evaluated for their anti-inflammatory activity. Different compounds were identified using HPLC, such as 6-gingerol and 6-gingediol from ginger juice and isorhamnetin and hesperidin from lemon juice. The results showed significant anti-inflammatory activities for both juices, especially the formulation combining the two. This study provides support for the development of nutraceutical preparations and further investigation of the compounds in ginger and lemon.
Review
Biochemistry & Molecular Biology
Tania Jimenez-Cabrera, Mirandeli Bautista, Claudia Velazquez-Gonzalez, Osmar Antonio Jaramillo-Morales, Jose Antonio Guerrero-Solano, Thania Alejandra Urrutia-Hernandez, Minarda De la O-Arciniega
Summary: Oxidative stress has negative impacts on health and contributes to the development of degenerative disorders, leading to pain. Compounds with antioxidant activity in the Erythrina genus may help in managing pain caused by inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Luiz Leonardo Saldanha, Aislan Quintiliano Delgado, Laurence Marcourt, Nathalia Aparecida de Paula Camaforte, Priscilla Maria Ponce Vareda, Samad Nejad Ebrahimi, Wagner Vilegas, Anne Ligia Dokkedal, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Jose Roberto Bosqueiro
Summary: The leaves of Bauhinia holophylla, traditionally used in Brazil to treat diabetes, have been found to contain multiple compounds that exhibit hypoglycemic activity, including lithospermoside. The hypoglycemic properties of the leaves seem to be the result of the activity of three unrelated classes of compounds, supporting their traditional use in treating diabetes.
Article
Food Science & Technology
Yue Xu, Yang Yang, Chun-min Ma, Xin Bian, Xiao-fei Liu, Yan Wang, Feng-lian Chen, Bing Wang, Guang Zhang, Na Zhang
Summary: In this study, soy isolate protein (SPI) was hydrolyzed using five enzymes. The effect of different enzymes on the structure and biological activities of the resulting hydrolysates was investigated. The alcalase hydrolysate exhibited the highest antioxidant and hypoglycemic activities. The structure of the hydrolysates was found to be unfolded after enzymatic treatment. The alcalase hydrolysate showed the greatest biological activities overall.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Plant Sciences
Marcello Nicoletti
Summary: The therapeutic story of European mistletoe has had ups and downs. In ancient times, it was considered a panacea, but recent concerns about its toxicity led to doubts about its medicinal value. However, its selective action on tumor cells has brought back medical interest in mistletoe.
Article
Chemistry, Applied
Mei Deng, Xuchao Jia, Lihong Dong, Lei Liu, Fei Huang, Jianwei Chi, Qin Ma, Dong Zhao, Mingwei Zhang, Ruifen Zhang
Summary: The Citrus genus is a good source of dietary flavonoids, with Shatianyu pulp containing various flavonoid compounds, among which naringin and rhoifolin exhibit high antioxidant activity. The structure of flavonoids also affects their antioxidant properties.
Article
Food Science & Technology
Juanjuan Zhang, Zhenhua Yin, Lin Chen, Baocheng Yang, Wei Zhang, Wenyi Kang
Summary: n-Butanol extract from the flowers of Amygdalus persica L. yielded fourteen compounds, with most of them being identified for the first time from the flowers of this plant. These compounds showed varying coagulation activities in vitro, including both procoagulant and anticoagulant effects.
JOURNAL OF FOOD QUALITY
(2021)
Article
Food Science & Technology
Nehleh Taghvaeefard, Askar Ghani, Mehdi Hosseinifarahi
Summary: The study analyzed the composition and antioxidant activity of essential oils from big and small citrons, finding that the antioxidant activity was higher in big citrons. Limonene was the main component in big citrons, while small citrons contained limonene, linalool, and linalyl acetate.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2021)
Article
Food Science & Technology
Vikas Dadwal, Robin Joshi, Mahesh Gupta
Summary: This study focused on metabolomic analysis of different parts of Citrus fruit using targeted and untargeted approaches. Different compounds were found in different parts of the fruit, with the highest concentration in the exocarp. The biological activities and potential therapeutic applications of these metabolites were investigated using computational and in vitro assays, showing promising results.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Medicinal
Milon Mondal, Sushmita Saha, Chandan Sarkar, Md Sakib Hossen, Md Solayman Hossain, Abul Bashar Ripon Khalipha, Md Fokhrul Islam, Tania Binte Wahed, Muhammad Torequl Islam, Abdur Rauf, Mohammad S. Mubarak, Sukalyan Kumar Kundu
Summary: The study confirmed the protective role of Citrus medica fruit extract against carbofuran-induced toxicity, demonstrating significant antioxidant and free radical scavenging abilities, possibly attributed to its polyphenolic constituents.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shunjie Li, Zimao Ye, Lintao Zhao, Yijun Yao, Zhiqin Zhou
Summary: Plant extracellular vesicles (PEVs) have attracted attention for their rich composition and therapeutic potential. In this study, citrus-derived extracellular vesicles (CEVs) were extracted from red mandarin and found to possess high levels of lipids, proteins, and carbohydrates. They also showed good antioxidant and anti-inflammatory properties and can serve as drug delivery agents. This study highlights the importance of utilizing citrus materials for the development of natural biomaterials with antioxidant and anti-inflammatory properties.
Article
Plant Sciences
Susana A. Dandlen, Jose P. Da Silva, Maria Graca Miguel, Amilcar Duarte, Deborah M. Power, Natalia Tomas Marques
Summary: The susceptibility of Citrus macrophylla (CM) to the severe Citrus tristeza virus (CTV), T36, is higher than that of Citrus aurantium (CA). The impact of host-virus interactions on host physiology remains largely unknown. This study evaluated the metabolite profile and antioxidant activity in the phloem sap of healthy and infected CA and CM plants. The results showed that the antioxidant enzyme activity increased significantly in infected CM plants and decreased in infected CA plants. Furthermore, CTV infection resulted in a drastic reduction in secondary metabolites in CA but not in CM.
Article
Chemistry, Applied
Mariangela Marrelli, Valentina Amodeo, Domenico Puntillo, Giancarlo Statti, Filomena Conforti
Summary: The fruits of Buglossoides purpurocaerulea were extracted and analyzed for their phytochemical composition and antioxidant activity. The extract showed a concentration-dependent antioxidant activity and exhibited an effective anti-denaturation effect on heat-treated bovine serum albumin.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Natale Badalamenti, Maurizio Bruno, Monica R. Loizzo, Valeria Puccio, Raimondo Gaglio, Nicola Francesca, Luca Settanni, Francesco Sottile
Summary: This study characterized the chemical composition of the almond skin of Prunus dulcis L. variety Casteltermini and evaluated its inhibitory activity against pathogenic, spoilage, and useful microorganisms. The n-hexane extract of almond skin showed strong inhibition against Staphylococcus aureus growth, indicating its potential as a food bio-preservative and pharmaceutical product.
NATURAL PRODUCT RESEARCH
(2023)
Article
Food Science & Technology
Vincenzo Sicari, Rosa Romeo, Antonio Mincione, Simone Santacaterina, Rosa Tundis, Monica Rosa Loizzo
Summary: This study investigated the phytochemical content and bioactivity of Lycium barbarum collected in Calabria and evaluated the possibility of enriching traditional ciabatta bread with goji fresh flesh puree. The enriched bread showed good levels of bioactive compounds and exhibited antioxidant and inhibitory activities against metabolic enzymes. Sensory analysis confirmed the slight modification in appearance but not in flavor and taste of the bread.
Review
Chemistry, Applied
Umile Gianfranco Spizzirri, Monica Rosa Loizzo, Francesca Aiello, Sabrina Antonia Prencipe, Donatella Restuccia
Summary: This review provides an overview of different types of non-dairy kefir products, which use fruits or vegetables as substrates for fermentation. The microbiological, chemical-physical, technological, and sensory aspects of each formulation are discussed, along with other potential health benefits.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Green & Sustainable Science & Technology
Vincenzo Sicari, Irene Maria Grazia Custureri, Rosa Tundis, Monica Rosa Loizzo
Summary: This study compared the physico-chemical characteristics and biological activity of olive mill wastewater (OMW) obtained by two different types of three-phase decanters: a traditional one and a water-saving ARA decanter. The results showed that the OMW extract obtained by the ARA decanter had a higher concentration of phenolic compounds, higher antioxidant activity, and moderate enzyme inhibitory activity, while reducing environmental impact.
Article
Biochemistry & Molecular Biology
Rosa Tundis, Giuseppina Augimeri, Adele Vivacqua, Rosa Romeo, Vincenzo Sicari, Daniela Bonofiglio, Monica Rosa Loizzo
Summary: This study characterized bamboo leaf and sheath extracts, revealing their antioxidant and anti-inflammatory properties. Bamboo leaves contain phenolic compounds, while sheaths are rich in phenolic acids. These findings suggest potential applications of bamboo leaf and sheath in the nutraceutical, cosmetic, and pharmaceutical industries.
Article
Food Science & Technology
Francesco Sottile, Assunta Napolitano, Natale Badalamenti, Maurizio Bruno, Rosa Tundis, Monica Rosa Loizzo, Sonia Piacente
Summary: For the first time, a new accession of myrobalan from Sicily was studied for its chemical and nutraceutical properties. The extracts of fresh myrobalan fruits were found to contain abundant phenolic compounds and antioxidants, with potential inhibitory effects on obesity and metabolic syndrome.
Review
Plant Sciences
Rosa Tundis, Jianbo Xiao, Ana Sanches Silva, Filipa Carreiro, Monica Rosa Loizzo
Summary: Citrus is a significant genus in the Rutaceae family, known for its medicinal and economic value, and including crops such as lemons, oranges, grapefruits, and limes. Citrus species are rich in carbohydrates, vitamins, dietary fiber, and phytochemicals, with various health-promoting properties. Citrus essential oils, mainly composed of monoterpenes and sesquiterpenes, have antimicrobial, antioxidant, anti-inflammatory, and anti-cancer properties. These oils are widely used in food, cosmetics, and pharmaceutical products.
Article
Food Science & Technology
Irene Maria Grazia Custureri, Vincenzo Sicari, Monica Rosa Loizzo, Rosa Tundis, Ana Cristina Soria, Angelo Maria Giuffre
Summary: The aim of this study was to investigate the impact of two enrichment processes on the quality and bioactivity of Ottobratica extra virgin olive oil with ginger. The results showed that the addition of ginger improved the antioxidant activity and inhibitory effect on enzymes.
Review
Plant Sciences
Rosa Tundis, Jayanta Kumar Patra, Marco Bonesi, Subrata Das, Rajat Nath, Anupam Das Talukdar, Gitishree Das, Monica Rosa Loizzo
Summary: Despite advancements in treatment strategies, cancer remains a leading cause of death globally. Therefore, the main focus should be on early cancer diagnosis, optimal therapeutic strategies, and the search for more effective molecules. This review comprehensively summarizes the potential anti-cancer properties of andrographolide, highlighting its mechanisms of action, pharmacokinetics, and potential side effects, while discussing future perspectives, challenges, and limitations of use.
Article
Biochemistry & Molecular Biology
Maria Concetta Tenuta, Monica Rosa Loizzo, Rosa Tundis, Annabelle Dugay, Chouaha Bouzidi, Arul Marie, Rosaria Acquaviva, Anna Rita Cappello, Brigitte Deguin
Summary: This study analyzed extracts of Cornus sanguinea and Cornus mas fruits and compared their inhibitory effects on key enzymes and their impact on health. Flavonoids, iridoids, and phenolic acids were identified as the main healthy compounds. The extracts from Cornus sanguinea showed significant antioxidant effects and promising enzyme inhibitory activity.
Article
Biochemistry & Molecular Biology
Maria Concetta Tenuta, Monica Rosa Loizzo, Rosa Tundis, Annabelle Dugay, Chouaha Bouzidi, Arul Marie, Rosaria Acquaviva, Anna Rita Cappello, Brigitte Deguin
Summary: In this study, extracts of Cornus sanguinea and Cornus mas fruits were analyzed using different extraction methods. The results showed that these extracts exhibited significant antioxidant activity and inhibited key enzymes associated with metabolic disorders. The findings suggest the potential use of Cornus species in the development of functional foods and nutraceuticals.
