Article
Microbiology
Lina Castano-Duque, Matthew D. Lebar, Carol Carter-Wientjes, David Ambrogio, Kanniah Rajasekaran
Summary: This study investigated the effects of three flavonoids on fungal proliferation and aflatoxin production in Aspergillus flavus. The results showed that the concentrations of apigenin and luteolin modulated fungal proliferation and aflatoxin production in a dose-dependent manner. Microscopy studies revealed disruptions in the mycelial cell wall and localization of flavonoids in sphere-like structures on the mycelia surface. Low concentrations of flavonoids also lowered the total antioxidant capacity in the environment. These findings suggest that flavonoids may disrupt cell wall integrity and act as potential signaling molecules, leading to reduction of fungal proliferation and aflatoxin production.
Article
Food Science & Technology
Vera Ribeiro, Federico Ferreres, Tiago Macedo, Angel Gil-Izquierdo, Andreia P. Oliveira, Nelson G. M. Gomes, Luisa Araujo, David M. Pereira, Paula B. Andrade, Patricia Valenta
Summary: The study investigated the phenolic composition of Xylopia aethiopica fruits and found potent cytotoxic effects against cancer cells, particularly towards AGS cells. The extract induced apoptosis and activated caspase-3, shedding light on the anticancer mechanisms of X. aethiopica fruits. Further research is needed to identify non-phenolic constituents contributing to these effects and to detail the anticancer mechanisms.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Thiago Anjos, Elba L. L. Gutterres, Daniela A. A. Barancelli, Roberta Cargnelutti, Benhur Godoi, Thiago Barcellos, Ricardo F. F. Schumacher
Summary: A synthetic method for organochalcogen-functionalized chromenones has been developed using diorganyl dichalcogenides and alkynyl aryl ketones. Selectfluor(R) mediates the cyclization/organochalcogenation reactions under mild and open-to-air conditions. The versatile methodology allows for the synthesis of organochalcogen-substituted thiochromenone and isocromenone derivatives.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Allah Rakha, Nehal Umar, Roshina Rabail, Masood Sadiq Butt, Marek Kieliszek, Abdo Hassoun, Rana Muhammad Aadil
Summary: Chronic inflammation plays a crucial role in chronic diseases, and flavonoids in diet have the potential to regulate inflammation and display anti-inflammatory properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Karin Johrer, Mayra Galarza Perez, Brigitte Kircher, Serhat Sezai Cicek
Summary: Phenolic constituents, especially flavone and flavonol derivatives, derived from plants have been shown to have apoptotic effects on myeloma and AML cells. Cirsimaritin and xanthomicrol, polymethylated flavones, exhibit potent antiproliferative effects at lower concentrations and are also identified as FLT3 inhibitors, suggesting their potential as lead structures for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alessandra Ferramosca, Stefano Lorenzetti, Mariangela Di Giacomo, Paola Lunetti, Francesco Murrieri, Loredana Capobianco, Vincenza Dolce, Lamberto Coppola, Vincenzo Zara
Summary: Plant bioactives, such as polyphenols, can have differential effects on sperm quality depending on their concentration, with some compounds improving mitochondrial function in asthenozoospermic samples. This study highlights the potential of natural antioxidants in nutraceutical supplementation for male infertility treatment.
Article
Engineering, Chemical
Rui Wang, Nan Ni, Qi-xian Zhang, Xu-lin Duan, Qiang He, Yuan-long Chi
Summary: Flavonoid aglycones and flavonol aglycones, such as apigenin and kaempferol, were successfully separated using a Zr(IV) immobilized collagen fiber (ZCF). The adsorption capacity of ZCF for kaempferol was higher than apigenin, and efficient separation of flavonol aglycones from flavonoid aglycones was achieved through ZCF column chromatography.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Aung Myooo Mohd Hasyam, Nasir Mat Nor, Liyana Hazwani Mohd Adman, Nor Zidah Binti Ahmad, Abdi Wira Septama, Nik Norul Najihah, Ohn Mar Lwin, Nordin Simbak
Summary: The study found that flavonoid compounds, including apigenin, luteolin, and quercetin, can induce proliferative effects on NK-92 cells, showing the highest percentage of proliferation at a certain concentration.
Article
Oncology
Rupesh Shrestha, Kumaravel Mohankumar, Greg Martin, Amanuel Hailemariam, Syng-ook Lee, Un-ho Jin, Robert Burghardt, Stephen Safe
Summary: Kaempferol and quercetin were found to bind NR4A1 protein and inhibit NR4A1-dependent transactivation in RMS cells. They also regulate cell growth, survival, mTOR signaling, invasion, and the expression of pro-oncogenic genes like PAX3-FOXO1 and G9a. In addition, kaempferol and quercetin showed tumor growth inhibition in a xenograft model, suggesting their potential as precision medicine for RMS patients expressing NR4A1.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Musa Tartik, Juan Liu, Marta Tous Mohedano, Jiwei Mao, Yun Chen
Summary: This study successfully engineered Saccharomyces cerevisiae for high production of flavonoids kaempferol and quercetin. Through reconstructing the biosynthetic pathway, optimizing enzyme expression, and increasing precursor availability, the production of kaempferol and quercetin reached 956 mg L-1 and 930 mg L-1 respectively in yeast. This research provides a promising platform for sustainable and scalable production of kaempferol, quercetin, and their derivatives.
MICROBIAL CELL FACTORIES
(2023)
Review
Chemistry, Medicinal
Marilyn S. Criollo-Mendoza, J. Basilio Heredia, Gabriela Vazquez-Olivo, Sara Aviles-Gaxiola, Erick P. Gutierrez-Grijalva, Melissa Garcia-Carrasco
Summary: Breast cancer is a major global disease with a high mortality rate, primarily affecting females. Although significant progress has been made in its treatment, research on less invasive therapies with fewer side effects is ongoing. This review summarizes studies on the antiproliferative activity of flavonoids obtained from natural sources for breast cancer treatment and discusses their mechanism of action related to their structural characteristics.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Lei Zhang, Kumaravel Mohankumar, Gregory Martin, Fuada Mariyam, Yuri Park, Sang Jun Han, Stephen Safe
Summary: NR4A1 plays a crucial role in the progression of endometriosis. Kaempferol and quercetin, natural compounds, act as NR4A1 antagonists and effectively inhibit the progression of endometriosis. They also suppress the growth of endometriotic lesions in mice.
Article
Engineering, Chemical
Maria G. Campos, Christian Frigerio, Otilia Bobis, Adriana C. Urcan, Nelson G. M. Gomes
Summary: Bee pollen is a nutritious substance that is prone to degradation during storage due to high moisture content, but an infrared-based technology can be used to determine moisture content and develop a drying technology without compromising its bioactive effects. This approach shows good reproducibility, reduces drying time and energy consumption, and can be scaled up for industrial use with low environmental impact as long as no degradation occurs during the radiation process.
Review
Nutrition & Dietetics
Felice Crocetto, Erika di Zazzo, Carlo Buonerba, Achille Aveta, Savio Domenico Pandolfo, Biagio Barone, Francesco Trama, Vincenzo Francesco Caputo, Luca Scafuri, Matteo Ferro, Vincenzo Cosimato, Ferdinando Fusco, Ciro Imbimbo, Giuseppe Di Lorenzo
Summary: The study investigates the anti-cancer potential of flavonols (kaempferol, fisetin and myricetin) in preventing bladder and prostate cancer. Research suggests that a higher dietary intake of flavonols is associated with a lower risk of both bladder and prostate cancer.
Article
Biochemistry & Molecular Biology
Daniel Kasungi Isika, Omowunmi A. Sadik
Summary: This study reported the synthesis and characterization of partial flavonoid acetamide derivatives from quercetin, apigenin, and luteolin, and evaluated their antioxidant, bioavailability, drug likeness, and toxicity properties. The results showed that chemical modification can improve the biological properties of flavonoids, making them potential drug candidates.